Patents Represented by Attorney Felicity E. Groth

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  • Pertussis toxin mutants, Bordetella strains capable of producing such mutants and their use in the development of antipertussis vaccines
    Patent number: 7666436
    Abstract: New pertussis toxin (PT) mutants are described being immunologically active and having reduced or no toxicity, characterized in that at least one of the amino acid residues Glu129, Asp11, Trp26, Arg9, Phe50, Asp1, Arg13, Tyr130, Gly86, Ile88, Tyr89, Tyr8, Gly44, Thr53 and Gly80 of subunit S1 amino acid sequence is deleted and substituted by a different amino acid residue selected in the group of natural amino acids; Bordetella strains capable of providing and secreting said PT mutants and means and methods for obtaining them are also described. The Bordetella strains and the PT mutants produced by them are particularly suitable for the preparation of effective cellular and acellular antipertussis vaccines.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: February 23, 2010
    Assignee: Novartis AG
    Inventors: Mariagrazia Pizza, Antonello Covacci, Rino Rappuoli, Luciano Nencioni
  • Methods of purifying authentic IGF from yeast hosts
    Patent number: 7071313
    Abstract: Methods for purifying authentic, properly folded IGF polypeptides from yeast transformants are disclosed. The methods include a refolding step and provide for high yields of authentic IGF from a variety of yeast strains.
    Type: Grant
    Filed: May 2, 2000
    Date of Patent: July 4, 2006
    Assignees: Cephalon, Inc., Chiron Corporation
    Inventors: Cynthia Cowgill, Luis Juarbe-Osorio, Patricio Riquelme, Glenn Dorin, Christopher M. Bussineau, Robert D Kudrna, Asuman G. Ozturk, Carl Scandella, Russell A. Brierley, Joan N. Abrams, John M. Hanson, Francis C. Maslanka