Abstract: This invention relates to a compound of the following formula: wherein R1, R2, R3, G, and Z are defined herein. It also relates to is methods of treating autoimmune disease, cancer, and atherosclerosis with such a compound.

Abstract: Systems and methods consistent with the present invention provide an address that does not conflict with other addresses. In one embodiment, a method includes receiving, at a first processor, a first packet; determining as a function of a multidimensional space for representing addresses processed by a set of data processors, a first address for the first packet; forwarding the first packet based on the determined first address.

Abstract: The disclosure provides compositions for simultaneously bleaching and dyeing keratin fibers, comprising at least one direct dye chosen from anionic and nonionic dyes, with the exception of 7-(6?-methylphenylazo)-1-acetamido-3,6-disulfo-8-hydroxynaph-thalene, ortho-nitroanilines substituted meta to the amino group, quinoline and quinoline derivatives, and addition salts thereof, at least one associative polymer, at least one peroxygenated salt and at least one alkaline agent, to processes for simultaneously bleaching and dyeing keratin fibers using the compositions, and to uses of the compositions for simultaneously bleaching and dyeing keratin fibers. The compositions are suitable for dark hair. They are easy to use and can produce chromatic and fast coloration.

Abstract: A probe which can be easily formed, is not limited in a mounting position and number, and capable of sufficiently securing a space allowing a contact to move is provided. The probe has a contact to be brought into contact with an inspection object, and a beam part supporting the contact at a tip end portion. A rear portion of the beam part of the probe is joined to a surface at an inspection object side, of a contractor disposed to be opposed to the inspection object. The beam part of the probe is bent so that the above described contact at the tip end portion inclines to the above described inspection object side.

Abstract: There is provided a system and method for monitoring an apparatus from a remote location. A vendor-side computer obtains operating state data obtained by a monitoring device provided in an apparatus via a communication line, and monitors the operating state of the apparatus from a remote location. Maintenance data at a part replacing time is transmitted from the apparatus, and the vendor-side computer that has received maintenance data calculates an optimal replacement period of a part based on this. The calculated optimal replacement period of each part is sent to a plant. The plant feeds the optimal replacement period back to the operating of the apparatus.

Abstract: Analysis data constituted by a plurality of parameters is acquired on the basis of detection values obtained in processes for an object to be processed from a detector arranged in a plasma processing apparatus. With respect to parameters of analysis data decided as abnormal data, as a degree of influence on abnormality, a contribution to, e.g., a residual score is calculated (degree-of-influence calculating step). Contributions of the parameters are set at 0 or a value close to 0 in a descending order of contribution of the parameters to sequentially calculate residual scores, and, when the residual scores are not more than a predetermined value, the parameters having the contributions which are set at 0 or a value close to 0 until now as parameters which cause abnormality (cause-of-abnormality deciding step).

Abstract: A recess gate of a semiconductor device includes: a substrate having a bulb-shaped recess pattern formed therein, wherein the bulb-shaped recess pattern includes a first ball pattern and a second ball pattern formed therein, the first ball pattern having a different diameter than the second ball pattern; a gate insulation layer formed over the bulb-shaped recess pattern and the substrate; and a conductive layer formed over the gate insulation layer and filling the bulb-shaped recess pattern.

Abstract: A conversion adapter to be used for connecting opposed optical connector ferrules having different diameters is formed of an amorphous alloy possessing at least a glass transition region, preferably a glass transition region of not less than 30 K in temperature width. Particularly, the amorphous alloy of M1—M2 system or M1—M2—La system (M1: Zr and/or Hf, M2: Ni, Cu, Fe, Co, Mn, Nb, Ti, V, Cr, Zn, Al, and/or Ga, La: rare earth element) possesses a wide range of &Dgr;Tx and thus can be advantageously used as a material for the conversion adapter. Such a conversion adapter can be manufactured with high mass-productivity by a mold casting method or molding method.

Abstract: A junction box of the present invention includes a junction box body, and a casing for housing the junction box body in either an upright position or a horizontal position. On the junction box body, provided is first locking piece to be engaged with a first inner side face of the casing in a state of upright disposition of the junction box body. The first locking piece abuts on a second inner side face of the casing in a state of horizontal disposition of the junction box body. In addition, also provided is second locking piece to be engaged with the first inner side face of the casing in the state of horizontal disposition of the junction box body. The second locking piece abuts on the second inner side face of the casing in the state of upright disposition of the junction box body.

Abstract: Camptothecin derivatives and pharmaceutically acceptable salts thereof, its manufacturing method and an antineoplastic agent containing it. The camptothecin derivatives are modified in B-ring and E-ring and show improved water solubility and enhanced antineoplastic effect.

Abstract: The device and method for reducing heart wall stress. The device can be one which reduces wall stress throughout the cardiac cycle or only a portion of the cardiac cycle. The device can be configured to begin to engage, to reduce wall stress during diastolic filling, or begin to engage to reduce wall stress during systolic contraction. Furthermore, the device can be configured to include at least two elements, one of which engages full cycle and the other which engages only during a portion of the cardiac cycle.

Abstract: Methods of preparing new taxoids of general formula (I) are presented: in which: R4 represents an alkanoyloxy radical in which the alkanoyl portion contains 2 to 6 carbon atoms in an unbranched or branched chain, this radical unsubstituted or substituted with one or more halogen atoms, an alkoxy radical containing 1 to 4 carbon atoms, or alternatively R4 represents a cycloalkanoyloxy radical in which the cycloalkanoyl portion contains 4 to 8 carbon atoms, or alternatively R4 represents a benzoyloxy radical; R5 represents an alkoxy radical containing 1 to 4 carbon atoms, substituted by an alkylthio radical containing 1 to 4 carbon atoms; and Z represents a hydrogen atom or a radical of general formula:

Abstract: Taxol (I) is a complex deterpene which is currently considered the most exciting lead in cancer chemotherapy. Taxol possesses high cytotoxicity and strong antitumor activity against different cancers which have not been effectively treated by existing antitumor drugs. However, taxol has a problem with solubility in aqueous media, which may impose some serious limitation in its use. Taxotére (III) seems to have antitumor activity superior to taxol with better bioavailability. Taxotére has a modified taxol structure with a modified C-13 side chain. This fact strongly indicates that modification on the C-13 side chain would provide a new series of taxol and Taxotére analogues which may have higher potency, better bioavailability and less unwanted toxicity. The present invention provides efficient and practical methods for the syntheses of Taxotére and its analogues through &bgr;-lactam intermediates and their coupling with baccatin III.

Abstract: A nucleotide sequence coding for at least one part of the terminal N region of a polypeptide which exercises a specific toxic effect on Lepidoptera of the Noctuidae family, preferably on S.littoralis, is characterized by its capacity for hybridization with a gene capable of expressing a polypeptide exercising a toxic effect on S.littoralis larvae.

Abstract: A process produces DNA corresponding to that of the DNA of the virus of B hepatitis. It comprises cloning in bacteria the latter DNA, previously repaired by means of the corresponding precursor nucleotides in the presence of a polymerase. Vectors contain the cloned DNA in their genomes. The cloned DNA is useful as a probe for detecting the presence of the virus of B hepatitis in biological samples, particularly blood or plasma. Its expression in bacteria provides a hybrid protein containing a protein fragment having vaccinating properties against hepatitis B. Nucleic acid of reduced size and a vector containing the nucleotide sequence of which DNA codes an immunogenic peptide sequence capable of inducing the generation of antibodies to the virus of viral hepatitis B. It comprises totally or partly the sequence of nucleotides represented in FIG. 9A.

Abstract: An apparatus and method are provided for separating components of a fluid or particles. A separation vessel having a barrier dam is provided to initially separate an intermediate density components of a fluid, and a fluid chamber is provided to further separate these the intermediate density component by forming an elutriative field or saturated fluidized particle bed. The separation vessel is placed in a retainer on a centrifuge rotor and ridges in the retainer form various dams in the separation vessel. Also discloses are tubing sets and various separation vessels for use with the apparatus.

Abstract: A self-extinguishing cable releasing low quantities of toxic and corrosive smokes and gases for optical or electrical applications, comprises a self-extinguishing coating (3), releasing low quantities of toxic and corrosive fumes and gases, comprising:a) a polymer base including from 30 to 60 parts of a thermoplastic polyester and from 40 to 70 parts of a silicone-polyimide polymer;b) at least 0.5 parts of an anti-hydrolysis agent of the thermoplastic polyester and at least 0.25 parts of a selected antioxidant agent per each 100 parts by weight of the polymer base.Advantageously, the antioxidant agent is so selected that the coating (3) has a value of percent elongation at break not lower than 80% of the starting value and in any case not lower than 250%, after a 10-day aging at 175.degree. C. in a hot air oven.

Abstract: A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1 (AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 of AAF1. When this substitution occurs in both alleles in one individual, it is associated with less evidence of atopic allergy including asthma, fewer abnormal skin test responses, and a lower serum total IgE. Thus, applicant has identified the existence of a non-asthmatic, non-atopic phenotype characterized by methionine at codon 117 when it occurs in both AAF1 gene products in one individual.

Abstract: A method and system are provided for pasteurizing a fluid product. Heated fluid product flows through a passageway to a directional flow valve for directing the heated fluid product through either a primary flow path or a divert flow path. A temperature sensor senses temperature of the heated fluid product at a location in the passageway spaced from the valve so that change in temperature of a portion of the heated fluid product is sensed before that portion of the heated fluid product flows to the valve. The valve directs flow of the heated fluid product from the passageway to the divert flow path when the sensed temperature is below a predetermined temperature for pasteurization of the fluid product, and continues to direct the flow to the diverting flow path at least until the sensed temperature is at or above the predetermined temperature for a predetermined period of time.

Abstract: A parking device for parking a handtruck on the floor of a truck or like vehicle so as to prevent accidental movement of the handtruck on the floor during movement of the truck. The device includes a frame which is comprised of two frame parts, of which the first part is longer and thicker than the second part and is beveled on one side for facilitating movement of a handtruck onto the parking device. The first part extends at both of its ends beyond the second part which is joined generally at right angles to the first part inwardly from the ends of the first part. A cavity defined by the second part of the frame receives the wheels of the handtruck, whereas the upper surface of the first part supports the remainder of the handtruck and thus the general weight thereof.