Patents Represented by Law Firm Firshauf, Holtz, Goodman, Langer & Chick, P.C.
  • Patent number: 5643923
    Abstract: Compounds of formula (I): ##STR1## wherein R.sup.1 is hydrogen, halogen or alkyl; R.sup.2 is hydrogen, alkyl, optionally substituted phenyl or a heterocycle; or R.sup.1 and R.sup.2 together form a group of formula --CR.sup.4 .dbd.CR.sup.5 --CR.sup.6 .dbd.CR.sup.7 --, where R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are hydrogen, halogen, alkyl group, alkoxy, halomethyl, alkylamino, dialkylamino, hydroxy, nitro, aliphatic carboxylic acylamino or amino; and R.sup.3 is piperidyl, substituted piperidyl or quinuclidinyl. The compounds are useful in the treatment and prophylaxis of cognitive disorders, notably senile dementia, including Alzheimer's disease. Processes for preparing the compounds are also provided.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: July 1, 1997
    Assignee: Sankyo Company, Limited
    Inventors: Mitsuo Nagano, Takeo Kobayashi, Junichi Sakai, Masao Kozuka, Nobuyoshi Iwata, Yoshiko Kubo