Abstract: An analyte testing device includes an analyte sensor, a lancet, and a mechanism with an actuator that operates to independently expose the analyte sensor and advance the lancet into position for use. The analyte sensor is preferably included in an analyte sensor cartridge that houses a plurality of sensors. Similarly, the lancet is preferably included in a lancet cartridge that houses a plurality of lancets. The actuator can be a lever configured to expose the analyte sensor and advance the lancet into position with a single motion (e.g., pulling the lever). The actuator also preferably operates to cock a hammer in preparation for lancing a body member to draw a blood sample. The mechanism can be a linkage coupled with the actuator and configured to engage the analyte sensor and lancet.

Abstract: The instant invention provides novel and effective methods of isolating alpha-1-antitrypsin from cryo-poor plasma and formulating it into therapeutic products. This invention achieves higher yields and a superior quality of alpha-1-antitrypsin. Alpha-1-antitrypsin is isolated from cryo-poor plasma, using one or more salts selected from a group comprising sodium citrate, sodium acetate, sodium gluconate, ammonium sulfate, sodium chloride, sodium sulfate and ammonium chloride in two fractionation steps, followed by diafiltration to remove those salts employed.

Abstract: A distributed computing bus that provides both data transport and ambient computing power is provided. Contemplated buses comprise a network fabric of interconnected networking infrastructure nodes capable of being programmed before or after installation in the field. A fabric manager organizes the fabric into a bus topology communicatively coupling computing elements that exchange payload data using a bus protocol. Nodes within the bus topology operate on the payload data as the data passes through the node on route to its destination.

Abstract: Contemplated compounds disrupt interaction between BRCA2 and RAD51, likely by binding to RAD51. Based on the crucial role of the BRCA2-RAD51 complex formation in DNA repair and the role of RAD51 in the control of entry into S-phase from G1, numerous compositions and methods are presented. Among other advantageous uses, contemplated compounds may be employed as protective agents for non-neoplastic cells in chemotherapy before exposure of the cells to a chemotherapeutic drug, and/or as DNA-damage sensitizer for neoplastic cells.

Abstract: Contemplated validation systems provide access to a master validator, one or more remote validators, and an authorized party such that validation using a validation script can be performed in a flexible manner that allows modifications to the script in real time. Typically, modifications are requested by a remote validator in the field where the remote validator can not answer a validation request generated by the validation script in a proper or predetermined manner. A master validator will receive the request and modify the validation script accordingly to allow the validation to proceed. Most typically, modification of the script is authorized by an authorized party.

Abstract: An animal deterring device has a carrier with a first conductive trace that is separated from a second conductive trace. The carrier has a bottom with a first glue trough disposed beneath the first conductive trace. The first conductive trace is coupled to the carrier by a first fastener that extends from the first glue trough to the first conductive trace.

Abstract: A wall-mounted component can be flush-mounted into a wallboard by first installing a panel with a receiver bracket flush into a wallboard. Once the panel is installed, the component can be inserted into the receiver bracket at which point a locking mechanism automatically or manually engages to lock the component into the wall. The locking mechanism is concealed from view so that a casual observer does not see how the component is affixed to the wall, yet is accessible from the wall's exterior for routine service and maintenance, as well as reinstallation of updated components.

Abstract: Methods for using a centrifuge are presented. A vessel containing a sample and a separator substance is placed within a centrifuge. Upon sufficient centrifugation, the sample separates into two or more fractions separated by the separator substance. The centrifuge exposes the separator substance to a sufficient energy to polymerize the separator substance to produce a hardened barrier between the fractions.

Abstract: A bird deterrent has a base and at least one branched spike extending from the base. The branching can occur anywhere along the spike, and a single branch point can give rise to multiple branches. Spikes can have multiple branches. The various branches can be of any suitable length(s), and can be oriented in any suitable direction(s).

Abstract: A rotorcraft having multiple rotors, and wings that provide lift in forward flight, has a mechanical coupling between rotors that can be disengaged and optionally reengaged, during flight. The coupling, which can prevent a failure of one rotor from interfering with rotation of the other rotor(s), can be accomplished using many different types of devices, including for example, dog clutches, friction clutches, and collapsible clutches. Disengagement can range from being completely under control of an operator, to partially under operator control, to completely automatic. Among many other benefits, designing, manufacturing, fitting, retrofitting or in some other manner providing an aircraft with a device that can disengage rotation of one of the rotors from that of another one of the rotors during flight can be used to improve survivability in an emergency situation.

Abstract: The density of “ready for take-off” aircraft on a flight deck of a ship is increased by orienting the aircraft at orientation angles between 20° and 180° from dead ahead. Preferred ships are modified from, or utilize a design derived from an existing ship, especially a large containership or other commercial ship. One or more payload staging decks can be advantageously located under the flight deck. All suitable types of aircraft are contemplated, including especially helicopters, tilt-rotors, and other rotorcraft. In preferred embodiments at least three, five, or ten aircraft are vertical take-off and landing (VTOL) aircraft. Also in preferred embodiments, at least five of the first plurality of the aircraft are capable of carrying a payload greater than 20,000 pounds.

Abstract: A method for controlling the synthesis gas composition obtained from a steam methane reformer (SMR) that obtains its feedstock as product gas directly from a steam hydro-gasification reactor SHR). The method allows control of the H2/CO syngas ratio by adjusting the hydrogen feed and the water content of feedstock into a steam hydro-gasification reactor that supplies the SMR. The steam and methane rich product gas of the SHR is generated by means of hydro-gasification of a slurry of carbonaceous material and water. The mass percentages of the product stream at each stage of the process are calculated using a modeling program, such as the ASPEN PLUS™ equilibrium process. By varying the parameters of solid to water ratio and hydrogen to carbon ratio, a sensitivity analysis can be performed that enables one determine the optimum composition of the slurry feedstock to the SHR to obtain a desired syngas ratio output of the SMR.

Abstract: The present invention generally relates to a communication protocol converter to allow a legacy device utilizing IPv4 to operate across the network using IPv6. In a first embodiment of the invention, two modular Ethernet connectors are placed side-by-side. A first modular connector receives IPv4 Ethernet data which is converted to a raw data signal. The data is transmitted from the first modular connector to a second modular connector by a bidirectional data line. The second connector receives the raw data, and a raw data-to-Ethernet conversion is completed providing output at IPv6. The present invention utilizes the form factor structure of the Ethernet connectors, so that the entire electronic circuitry is contained within the connectors to complete the conversion. An alternate embodiment incorporates the connectors into a single housing and the conversion is completed internally by a microprocessor and embedded software. A method of IPv4 to IPv6 conversion is additionally disclosed.

Abstract: Paper or plastic cups, plates, and paper utensils are held in place on a table attaching a table cloth to a table, and then attaching by tableware holders to the table cloth. The table cloth and the tableware holders have mating fasteners that prevent the tableware holders from moving relative to the table cloth. Each tableware holder is sized and dimensioned to receive different types of tableware and each holder has stabilizers that prevent the tableware from blowing off of the table.

Abstract: The present invention provides systems and methods for generating replenishment orders for products sold to a multi-store retailer. Store trait data is mapped with planogram information and the mapped data is used to generate a fixture level safety stock for a particular product in a particular store. The fixture level safety stock triggers fixture level replenishment orders.

Abstract: Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.

Abstract: A bearing remover is configured to cooperate with a puller to remove a bearing from an axle. The bearing remover includes a claw that has an opening to receive a portion of the axle, and a lip that can be inserted between the bearing and the wall. The bearing remover also includes a centering component that fits about the axle. The claw and centering component are mechanically coupled to assist in maintaining the claw about the bearing, and to transmit a force to the claw.

Abstract: A bird repellent apparatus having an integral base member and a plurality of prongs. The base member, by means of a plurality of tabs having holes for receiving screws or other fasteners, can be affixed to virtually any desired surface. The plurality of prongs with sharp tips presents an impossible barrier to birds that would otherwise land or perch on the surface to which the present invention is affixed. The combined base member and prongs are formed from injection molded plastic structure that also provide the tabs having holes to secure the base member to the underlying surface.

Abstract: A combination bite block, tongue elevator/retractor and airway for establishing and maintaining an open airway while preventing emergence clenching and the resulting dental and soft tissue damage associated with emergence clenching in procedures where anesthesia and/or sedation are used, or when the patient is not in control of their own airway, regardless of the cause. The inventive subject matter includes a tongue elevator/retractor component in both right and left conformations; and a bite block component. The bite block component is a wedge shaped, compressible component that is inserted between the upper and lower molars on either the right or left side of the mouth. The tongue elevator component is comprised by a flat portion of that is inserted into the side of the bite block, and an optional curved portion that retracts the tongue off of the posterior pharynx when in place.

Abstract: Contemplated substituted arylpiperazinyl compounds, and most preferably 18F-Mefway, exhibit desirable in vitro and in vivo binding characteristics to the 5-HT1A receptor. Among other advantageous parameters, contemplated compounds retain high binding affinity, display optimal lipophilicity, and are radiolabeled efficiently with 18F-fluorine in a single step. Still further, contemplated compounds exhibit high target to non-target ratios in receptor-rich regions both in vitro and in vivo, and selected compounds can be effectively and sensitively displaced by serotonin, thus providing a quantitative tool for measuring 5-HT1A receptors and serotonin concentration changes in the living brain.