Abstract: A method of forming Supercondtuctors with high critical temperature is described in which heterostructures at the atomic limit are realized artificially by molecular beam epitaxy, sputtering, lithography, chemical synthesis, electrochemical deposition or other similar technologies, made by a plurality of first portions of a superconducting metallic material forming a lattice of substantially equal elements with constant period &lgr;p, at least in a first direction (y), and a plurality of second portions formed by a material with different electronic structure from that of the first portions, intercalated to the first portions to realize the separation between said first portions; the heterostructure is characterized by the fact that the plurality of first portions have a size (L) and a period (&lgr;p) as to satisfy the condition for the shape resonance condition for the electrons at the Fermi level and the plurality of second portions have a size (W) smaller or of the order of the superconducting Pippard cohe

Abstract: A decoder is used in an end-to-end scalable video delivery system operable over heterogeneous networks. The decoder may software-based and computationally low complexity, or may be implemented inexpensively in ROM hardware. The system utilizes a scalable video compression algorithm based on a Laplacian pyramid decomposition to generate an embedded information stream. At the receiving end, the decoder extracts from the embedded stream different streams at different spatial and temporal resolutions. Decoding a 160×120 pixel image involves only decompressing a base layer 160×120 pixel image. Decoding a 320×240 pixel image involves decompressing and up-sampling (e.g., interpolating) the base layer to yield a 320×240 pixel image to which is added error data in a first enhancement layer following its decompression.

Abstract: An improved flash EEPROM memory-based storage subsystem includes one or more flash memory arrays, each with a duplicity of data registers and a controller circuit. When data are read from a flash array into a data register, the data is copied to a second register so that, during the ensuing program operation into the same array, the data may be transferred to the controller for the purpose of checking the data validity. This creates an improved performance system that doesn't suffer data transfer latency during copy operations but that is able to guarantee the validity of the data involved in such operations.

Abstract: A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents. In a preferred embodiment the methods include detecting a change in an optical property around a microsphere on an array.

Abstract: The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, the invention provides methods utilizing the solid supports to hybridize probe nucleic acid to target nucleic acid and methods for detecting the hybridization complex.

Abstract: Method of enhancing blood flow in tissue wherein an implant is non-ablatively introduced into the tissue in order to stimulate production of angiogenic agents by the tissue, the agents produced by the tissue are absorbed into the implant, where they are stored, and the stored agents are released back into the tissue when the production of agents by the tissue subsides. The implant is fabricated of a bioresorbable material and is resorbed into the tissue after the agents are released. In some embodiments, an exogenous angiogenic agent in included in the implant and released into the tissue along with the agents which are produced by the tissue and absorbed by the implant.

Abstract: A microwave broadside coupled balun integral in a multi-layer printed wiring board formed by broadside coupled conductors embedded in the multi-layer printed wiring board. The balun may be used to form components which are integrated into the multi-layer printed wiring board, such as a microwave mixer formed by two of said broadside coupled baluns embedded in a multi-layer printed wiring board and connected to a diode ring quad.

Abstract: There is described a capacitive micromachined ultrasonic transducer array which is configured to minimize the excitation and propagation of plate waves traveling in the substrate and ultrasonic waves propagating at the interface between the array surface and the immersion fluid.

Abstract: Vibratory tuning fork having a body of piezoelectric material with a base and a pair of tapered tines which extend from the base and decrease in lateral dimension from the base toward the tips of the tines. A crotch section at the base of the tines has an inner pair of faces which lie in crystallographic planes of the piezoelectric material and an outer pair of faces which lie in additional crystallographic planes of the material and extend between the inner pair of faces and the tines. An isolation slot is formed in the base adjacent to the crotch, with enlarged cut-outs at the ends of the slot to prevent the formation of facets and membranes across the slot.

Abstract: A novel structure and method are taught for fully discharging a capacitor and thereby reducing the capacitance needed to achieve a desired RC time constant. The invention overcomes the previously encountered problem of using a large and area-inefficient capacitor. The invention allows for conservation of integrated circuit space and is cost effective.

Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

Abstract: A canopy top for use with a vehicle having an open passenger compartment and carrying equipment. The canopy top has a frame adaptable for being secured to the vehicle and supported above the passenger compartment. A canopy overlies the frame. Means formed integral with the frame for securing equipment to the top is provided.

Abstract: A transfer valve assembly (10) for use as a feed valve or a discharge valve includes a series of open-faced pockets (46) biased by leaf springs (48) off of a central hub (44) and an arcuate saddle piece (22) mounted at an opening (14) of a sterilizer vessel (12) for transferring containers from an infeed conveyor (34) onto an interior reel (18). The engagement of open-faced pockets (46) with saddle (22) creates a seal to prevent the escape of steam, but gaps are provided between pockets (46) which allow for a controlled escape of steam in a manner that allows the pressure within the sterilizer vessel to be maintained at a slightly elevated level.

Abstract: The present invention concerns novel methods for enhancing the mechanical performance of tissue adhesives and sealants which comprises employing a primer molecule in association with a tissue adhesive or sealant, wherein the primer molecule serves to enhance the strength of the interface between the tissue and the adhesive matrix. The primer molecules described herein function to interact with a protein present in the tissue, thereby altering its characteristics to make it more amenable to bonding with the adhesive matrix. Primer molecules may be applied to the tissue independently from the tissue adhesive or sealant or may be mixed with the tissue adhesive or sealant prior to application to the tissue.

Abstract: There is disclosed an apparatus (1) for use in a suction blister technique of sampling fluid from the human or animal body. The apparatus (1) comprises a cup (2) defining a chamber and having a rim portion (3) defining an aperture (5) communicating with the chamber. An annular flange (6) extends outwardly from the rim portion (3) whereby in use the flange (6) is sealingly attached to the body such that an area of skin closes the aperture (5). A ducted portion (11) is connected to the cup (2) and defines duct (12) which communicates with the chamber. The cup (2) further comprises a roof (4) which merges with the rim portion (3) and is formed of a resiliently deformable material having a shape memory which urges the roof (4) into an expanded configuration in which the roof (4) is held clear of the aperture (5). The roof is however deformable to a collapsed configuration in which it is proximal to the aperture (5).

Abstract: Air conditioning system and method in which a refrigerant from a compressor is circulated through a cooling element within a hermetically sealed, thermally insulated cooling compartment to cool a fluid within the compartment, and transferring the cooled fluid out of the compartment for use in cooling a space. In one disclosed embodiment, the fluid which is cooled is air which is blown out of the compartment into the space to be cooled. In another disclosed embodiment, the fluid is a coolant which is contained within a vertically extending tube that extends both within the compartment and through a heat exchanger positioned beneath the compartment, with air being cooled by blowing it through the heat exchanger and then into the space to be cooled.

Abstract: The invention relates to methods for targeting an exogenous polynucleotide or exogenous complementary polynucleotide pair to a predetermined endogenous DNA target sequence in a eukaryotic cell by homologous pairing, particularly for altering an endogenous DNA sequence, such as a chromosomal DNA sequence, typically by targeted homologous recombination. In certain embodiments, the invention relates to methods for targeting an exogenous polynucleotide having a linked chemical substituent to a predetermined endogenous DNA sequence in a metabolically active eukaryotic cell, generating a DNA sequence-specific targeting of one or more chemical substituents in an intact nucleus of a metabolically active eukaryotic cell, generally for purposes of altering a predetermined endogenous DNA sequence in the cell.

Abstract: Improved oral cyclosporin formulations which have high bioavailability and are capable of admiration in hard capsules are provided. In the subject formations, cyclosporin is delivered in an orally acceptable vehicle comprising at least one alkanol solvent of from 2 to 3 carbon atoms in combination with at least one non-ionic surfactant. The subject formalations may further comprise at least one cosolvent, where cosolvents of interest include fatty acids and diols. The subject formulations find use in immuno-suppressive therapy.

Abstract: The invention provides antibodies directed against a G protein-activated, inward rectifying KGA potassium channel polypeptide.

Abstract: A GPS system and method for generating precise position determinations. The GPS system includes a ground based GPS reference system which receives with a reference receiver GPS signals and makes phase measurements for the carrier components of the GPS signals. The GPS reference system then generates and broadcasts an initialization signal having a carrier component and a data link signal having a data component. The data component of the data link signal contains data representing the phase measurements made by the reference receiver. The GPS system also includes a GPS mobile system which receives with a mobile position receiver the same GPS signals as were received by the reference system. In addition, the GPS position receiver receives the data link and initialization signals broadcast by the reference system.