Abstract: The present invention discloses a membrane stack comprising a first and second membrane layers, and a spacer layer disposed between said first and second membrane layers, said membrane stack configured such that fluid passes through said membrane stack in a direction substantially perpendicular to the plane of said membrane layers and said spacer layer. The application also discloses a module comprising a membrane as described above, said module having a fluid flow path that is substantially perpendicular to the plane of the major surface of the membrane and spacer layers ins aid membrane stack.

Abstract: The present disclosure relates in part to a flow field structure comprising a hydrophilic part and a hydrophobic part communicably attached to each other via a connecting interface. The present disclosure further relates to electrochemical cells comprising the aforementioned flow fields.

Abstract: Certain aspects of the invention relate to antibiotics, as well as pharmaceutically acceptable salts, pro-drugs and/or analogs thereof. Another aspect of the invention relates to methods of use of said antibiotics.

Abstract: The invention provides novel TRIM polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length TRIM proteins, the invention further provides isolated TRIM fusion proteins, antigenic peptides and anti-TRIM antibodies. The invention also provides TRIM nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an TRIM gene has been introduced or disrupted. The present invention also provides methods and compositions for the diagnosis and treatment of viral infection and/or replication, e.g., HIV infection. The invention further provides methods for identifying a compound capable of treating or preventing viral infection and/or replication, e.g., HIV infection and AIDS. In addition, the invention provides a method for treating a subject having a viral infection and/or replication, e.g.

Abstract: Joint replacement spacers that fully seat against the cut surface of a bone while remaining free to move on the cut surface within prescribed limits; methods of joint replacement using such spacers.

Abstract: The present invention relates to heterocyclic compounds that bind to Bcl proteins and inhibit Bcl function, compositions comprising such compounds, and methods for treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract: An embodiment of an LNA includes a voltage input, a voltage output, an input transistor connected as a source follower with a current source at the drain and source nodes of the input transistor, an input resistor connected between the source follower source node and signal ground, a gain boosting transistor with the gate connected to the input transistor drain node, wherein the source node is connected to ground and the drain node is connected through a load resistor to the input transistor source node. Such an LNA provides substantial improvement in power efficiency by adapting an output stage of the LNA to reuse the supply current of the input transistors to the LNA through a load resistor.

Abstract: Methods and apparatus are described wherein a charged beam in an enclosed conducting cavity in an accelerator is monitored for position, current, and energy. One method uses induced electric signals on non-intercepting conducting electrodes. Another method uses an intercepting and moving electrode than can be moved into the beam to different degrees to monitor the beam current and vertical profile at different radial positions. Non-intercepting electrodes are also used as part of a moving diagnostic probe to monitor properties of the beam at different radial positions. Another method uses the current in the leads to a power supply, a portion of this current being equal to the beam current. Another method uses the magnetic and electric fields from the beam that penetrates a non-conducting portion of the conducting cavity. Yet another method uses the radiation emitted during acceleration of the beam by the deflecting magnets that guide the beam.

Abstract: Provided is an assay device and kit for detecting the presence or amount of an analyte of interest.

Abstract: The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active inhibitor moiety in proximity to a target protease. In certain instances, compounds inhibit proteasomes and/or post-proline cleaving enzymes (PPCE), such as dipeptidyl peptidase IV. The compounds of the invention provide a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease.

Abstract: One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate the mixing of the solids and liquids inside the applicator. In addition, in certain embodiments, the applicator systems are also designed to facilitate the application of the mixture to a surface.

Abstract: A method is described wherein the acceleration of a beam of charged particles is achieved using the properties of conductors to limit the penetration of magnetic and electric fields in short times compared to natural time constants. This allows the use of induction electric fields with a Curl localized to a gap to accelerate particles while coupling the accelerated beam to a power supply. Two methods of coupling the particle beam to the power supply are disclosed as exemplary.

Abstract: One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to arylammonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the ammonium compound is a tetraaryl ammonium salt. Another aspect of the invention relates to arylsulfonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the sulfonium compound is a triaryl sulfonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.

Abstract: A method for detecting nuclear species in a sample by adaptive scanning using nuclear resonance fluorescence may comprise illuminating the target sample with photons from a source; detecting a signal in an energy channel; determining a scan evaluation parameter using the signal detected; determining whether the scan evaluation parameter meets a detection efficiency criterion; adjusting one or more system parameters such that the scan evaluation parameter meets the detection efficiency criterion; and comparing the signal in an energy channel to a predetermined species detection criterion to identify a species detection event. In another embodiment, detecting a signal in an energy channel may further comprise detecting photons scattered from the target sample. In another embodiment, detecting a signal in an energy channel may further comprise detecting photons transmitted through the target sample and scattered from at least one reference scatterer.

Abstract: Provided are devices and methods for the collection of bioaerosols (such as viruses, bacteria, and proteins) from the exhaled breath of humans and/or animals, for the purpose of determining, for example, particle size, generation rate, diseases and interventions for particle release.

Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

Abstract: A device may include a first plate and a second plate, and a linkage system that attaches the first plate and the second plate to one another such that the plates are capable of translating relative to each other, and the plates are incapable of rotating relative to each other.

Abstract: A method and apparatus for separating draw solution solutes and product solvent from a draw solution using a plurality of distillation columns is disclosed. In one embodiment, the draw solution is used in a Forward Osmosis (FO) water desalination process. In this embodiment, the draw solution is directed to the plurality of distillation columns in parallel while the energy stream (heat) is directed to the plurality of distillation columns in series such that the efficiency of heat use is improved and in turn the cost of the heat is reduced.

Abstract: Telemark ski bindings may incorporate a rotational decoupler as disclosed. When exposed to subthreshold torques during normal use, the ski boot will remain rotationally coupled to (i.e, cannot rotate relative to) the ski. When exposed to threshold- or suprathreshold torques, such as when a skier loses control, the ski boot will become rotationally decoupled from (i.e., can rotate relative to) the ski, thereby protecting the skier's legs from the excessive torque and resulting leg injury. Also disclosed are tracked/railed alpine touring and telemark bindings, as well as methods for interchanging such bindings on railed/tracked skis.

Abstract: A method and system for accelerating receipt of data in a client to client network. The method includes the steps of intercepting queries and responses, storing the intercepted queries and responses in an acceleration server and transmitting the intercepted responses to clients submitting intercepted queries. The system includes at least one acceleration server designed and configured to perform the steps included in the method.