Abstract: Chemical entities of Formula I, II, or III, pharmaceutical compositions and methods of treatment of cancer are described.

Abstract: The present invention relates to a chip having a metal pillar structure. The chip includes a chip body, at least one chip pad, a first passivation layer, an under ball metal layer and at least one metal pillar structure. The chip body has an active surface. The chip pad is disposed on the active surface. The first passivation layer is disposed on the active surface, and has at least one first opening so as to expose part of the chip pad. The under ball metal layer is disposed on the chip pad. The metal pillar structure is disposed on the under ball metal layer, and includes a metal pillar and a solder. The metal pillar is disposed on the under ball metal layer. The solder is disposed on the metal pillar, and the maximum diameter formed by the solder is shorter than or equal to the diameter of the metal pillar. Therefore, when the pitch between two adjacent metal pillar structures of the chip is a fine pitch, the defect of solder bridge can be avoided, so that the yield rate is improved.

Abstract: At least one of the conductive members has a hollow storage portion that is formed at the conductive member and a communication hole through which the storage portion and the vacuum chamber communicate with each other, a getter is set inside the storage portion, and an adsorbed object such as metal particles and gas in a vacuum chamber is adsorbed by the getter. By prevent application of the electric field to the getter, even though the electric field appears in a vacuum casing, a temperature of the getter does not reach a re-release temperature, and also electron stimulus desorption phenomenon does not occur, then it is possible to prevent the metal particles and the gas etc. which have been adsorbed once by the getter from being released.

Abstract: Systems, methods, and computer-readable media that may be used to present messages posted on messaging networks to a user in a time-shifted manner are provided. One method includes transmitting a request to a server to provide messages posted by users of one or more messaging services. Each of the messages has a timestamp associated therewith that falls within a time range associated with the request. The method further includes receiving the messages from the server and correlating, for each of the messages, the time at which the message was originally posted with a time in the time range associated with the request. The method further includes transmitting, to one or more display devices, display data representing the messages. Display of each of the messages is shifted based on the correlation such that the messages are displayed in substantially the same manner as if the messages had been viewed live.

Abstract: An object of the present invention is to promote hair growth or hair regeneration by promoting formation and/or regeneration of hair follicles. A method is provided for promoting formation and/or regeneration of hair follicles, comprising maintaining or increasing expression of one or a plurality of genes involved in cell adhesion in dermal papilla cells.

Abstract: A vector of the present invention has DNA encoding a protein or a product having the same effect as the protein, the protein containing an amino acid sequence from amino acid numbers 47 to 802 in SEQ. ID. NO:2. Expression of the DNA gives human chondroitin synthase. By using human chondroitin synthase, it is possible to produce a saccharide chain having a repeating disaccharide unit of chondroitin. The DNA or part thereof may be used as a probe for hybridization for the human chondroitin synthase.

Abstract: A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.

Abstract: Operability of a web application comprising dynamic contents is evaluated continuously with high precision. In a web application execution system 1000, a web server apparatus 121 responsive to a request from a client apparatus 101 and a log server apparatus 141 are connected via a network 161. The log server apparatus 141 stores an operation log obtained when the web application is operated on the web browser in accordance with a manual having a description of an operation method of the web application, as a first operation log, stores another operation log obtained when the web application is operated in the client apparatus 101, as a second operation log, and transmits difference information between the first and second operation logs to the web server apparatus 121, the client apparatus 101 or a different external apparatus 181 to cause the difference information to be at least displayed or recorded.

Abstract: The present disclosure relates to a portable archery target. The portable archery target includes a main target body having a geometric shape. The geometric shape has a first side and a second side. The first side has a first target zone, while the second side has a second target zone that is separate and distinct from the first target zone. At least one of the first target zone and the second target zone has a first three-dimensional animal-simulating indicia. The present disclosure also relates to a method of manufacturing a portable archery target. The method includes adding a resin into a mold cavity that defines a geometric shape of the portable archery target. The mold cavity has a first surface that defines a first target zone and a second surface that defines a second target zone. At least the first surface has a contour that provides a three-dimensional animal-simulating target. The method also includes closing the mold cavity to form a foam body and removing the foam body from the mold cavity.

Abstract: A novel technique is provided, which can secure sufficient adhesion of an Si layer and a magneto-optical material layer while avoiding occurrence of cracks when fabricating an optical nonreciprocal element by bonding the Si layer on which a rib waveguide is formed, and the magneto-optical material layer. The method includes forming a waveguide on the Si layer of an SOI substrate which is a first substrate, forming a first thin-film buffer layer on the aforesaid waveguide, forming a second thin-film buffer layer on an magneto-optical material layer deposited on a second substrate by using a same material as that of the aforesaid first thin-film buffer layer, and bonding the aforesaid first thin-film buffer layer and the aforesaid second thin-film buffer layer in placement where a light propagating in the aforesaid waveguide can be caused to generate nonreciprocal phase change by the aforesaid magneto-optical material layer.

Abstract: A method for enabling a feature provided by a first presentation layer protocol, within a session established according to a second presentation layer protocol includes intercepting, by a hooking component executing on a first machine, a request, by an operating system executing on the first machine, for an indication whether the first machine established a session with a second machine according to a first presentation layer protocol. The method includes determining that the first machine established a session according to a second presentation layer protocol. The method includes identifying a type of a function within the operating system that generated the request for the indication. The method includes indicating that the first machine established the session according to the first presentation layer protocol, responsive to the identification of the type. The method includes enabling functionality provided for use in sessions established according to the first presentation layer protocol.

Abstract: The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator intervention or decision making. The method provides for precise definition of tissue, cellular or subcellular compartments particularly in histological tissue sections in which to quantitatively analyzing protein expression.

Abstract: In some embodiments, a land vehicle includes sensors that provide information relating to a ride height of the land vehicle. A processing circuit monitors data from the sensors and controls adjustment of one or more vehicle systems that affect the vehicle's ride height based on the data from the sensors. In some embodiments, the processing circuit controls a suspension system and can control the suspension system to have any of a multiplicity of height settings. In some embodiments, the processing circuit controls the ride height based on a user selection of a pre-configured ride height setting. In some embodiments, the processing circuit is configured to maintain a ride height of the vehicle at a consistent ride height when the suspension is unlocked after a load is removed where the suspension was locked after the load was added.

Abstract: A slider actuates profiled closure shapes for a closure assembly equipping a sachet. The slider includes a base, two flanks, means adapted for stressing respectively said profiled closure shapes, by moving towards or moving away according to a direction of displacement of the slider along the profiled closure shapes, such that the profiled closure shapes are movable between a closed latch position and an open separated position, and a stiffening bar extending along a longitudinal free edge of each of the two flanks. The stiffening bar has a greater thickness than a thickness of its respective flank, extends over an external face of its respective flank, is made from a piece with its respective flank, and has a same longitudinal range as its respective flank.

Abstract: An adhesion method capable of strongly adhering two members without using an adhesive and without impairing a fine structure or optical properties of a joining surface, and a biochemical chip and optical component made by the same are provided.

Abstract: A flat panel display includes a backlight with a plurality of lasing elements. A light distributor distributes light from the lasing elements across the flat panel display. In edge-lit backlights, the light distributor may be a light guide. In direct-lit backlights, the light distributor may be one or more light diffusers that randomize the polarization of light. A polarization enhancement film increases the polarization of light from the light distributor by allowing light of a first polarization to pass through the film and reflecting light that is not of the first polarization back into the backlight. The light reflected back into the backlight is randomly re-polarized within the backlight. An array of light modulators arranged across the flat panel display modulates light emitted by the backlight.

Abstract: When an IP terminal on the Internet side transmits a name resolution request, which requests to resolve the FQDN of a public server connected to a router, to a SIP/DNS server in which SIP and DNS cooperate to manage the status of the data line of the router and when the data communication line status of the router is a disconnect status, a data communication line connection request instruction is transmitted to the router. The router connects the data communication line and notifies the SIP/DNS server about the result. The SIP/DNS server transmits the IP address of the router to the IP terminal as a response.

Abstract: This invention relates to a new and distinct variety of strawberry plant named ‘BG-4316’. This new strawberry plant named ‘BG-4316’ is primarily adapted to the growing conditions of the central coast of California, and is primarily characterized by its acute terminal leaflet base, medium to strong anthocyanins on the fruiting truss, orange red fruit color, medium-sized fruit, and calyx is slightly to much larger than the fruit.

Abstract: This invention relates to a new and distinct variety of strawberry plant named ‘BG-3.324’. This new strawberry plant named ‘BG-3.324’ is primarily adapted to the growing conditions of the central coast of California, and is primarily characterized by its early fruit production, moderate to strongly expressed core cavity, medium to light yellow green foliage, orange red to red fruit color, and very large fruit size.

Abstract: This invention relates to a new and distinct variety of strawberry plant named ‘BG-4315’. This new strawberry plant named ‘BG-4315’ is primarily adapted to the growing conditions of the central coast of California, and is primarily characterized by its weak interveinal blistering, acute terminal leaflet base, inner calyx is smaller than outer calyx, orange red to red fruit color, and medium to large fruit size.