Patents Represented by Attorney, Agent or Law Firm France Cote
  • Candida albicans KRE9 and uses thereof
    Patent number: 6582911
    Abstract: The present invention to an isolated DNA which codes for a gene essential for cell wall glucan synthesis of Candida albicans, wherein the gene is referred to as CaKRE9, wherein the sequence of the DNA is as set forth in FIG. 1. The present invention relates to antifungal in vitro and in vivo screening assays for identifying compounds which inhabit the synthesis, assembly and/or regulation of &bgr;1,6-glucan. There is also disclosed an in vitro method for the diagnosis of disease caused by fungal infection in a patient.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: June 24, 2003
    Assignee: McGill University
    Inventors: Howard Bussey, Marc Lussier, Anne-Marie Sdicu, Sarkis Serge Shahinian
  • Method for folding unfolded proteins
    Patent number: 6476194
    Abstract: The present invention relates to methods of treating and diagnosing protein trafficking disorders and controlling secretory protein production. The present invention also relates to methods for folding unfolded proteins, especially in heterelogous expression systems. The methods comprise exposing an unfolded protein to a biological preparation comprising ERp57 in combination with calnexin or calreticulin under conditions to permit folding of the unfolded protein.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: November 5, 2002
    Assignee: National Research Council of Canada
    Inventors: Daniel C. Tessier, Andrë Zapun, John J. M. Bergeron, David Y. Thomas