Abstract: A bioerodible controlled release dosage form is disclosed comprising a polymer formed by condensing beneficial agents having a hydroxyl functionality of two or more with diketene acetals or divinyl ethers which delivers beneficial agents to a biological environment of use. A statistically significant portion of the beneficial agent is covalently bonded within the polymer matrix.
Type:
Grant
Filed:
September 2, 1992
Date of Patent:
November 17, 1998
Assignee:
Merck & Co., Inc.
Inventors:
Chung Shih, Gaylen M. Zentner, Randall V. Sparer, R. Lee Seward