Abstract: An intravitreal injection system for administering a pharmacological agent formulation to an intravitreal compartment of an eye, comprising (i) an injection member coupled to, or comprising, an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein, (ii) a needle having a first end that is in communication with a formulation chamber and a second injection end, and (iii) a movable platform for positioning the system on the eye, guiding the needle, and limiting the penetration depth of the needle into the eye.

Abstract: A tennis skill training device having grip emulating a tennis racquet grip sized to be held by a user. The device includes a grip, a single flexible umbilical having a first and second ends, the first end being attached to and emanating from the distal end of the grip, and a weight attached to the second end of the umbilical.

Abstract: A system and apparatus for detecting unauthorized movement of a moveable object where the system includes a GPS receiver, cellular modulator, processor, pager modem, sensor and two-way pager. When the system is coupled to a moveable object and is armed via the pager, the sensor is monitored by the processor to determine when a possible theft of the moveable object may be occurring. In an embodiment, the sensor is a multiple axis accelerometer. In one embodiment the accelerometer is a two axes accelerometer where the sensor detects small movements of the object is two axes. When the sensor is triggered, the processor pages the two-way pager. The processor also determines the system's location via the GPS receiver. The processor generates a message including the system's location and unique system identifier. The processor transmits the message to a monitoring center via a cellular network (and the cellular modulator).

Abstract: A system for measuring intraocular pressure (IOP) of an eye, comprising a plurality of force sensors that are adapted to contact a surface of an eye, means for measuring the forces exerted on the force sensors when in contact with the eye surface, and processing means that is adapted to receive the measured forces and determine IOP of the eye as a function of the measured forces.

Abstract: The invention comprises a gastric device having a pouch formed from a degradable film. Preferably, the pouch contains a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.

Abstract: The present invention provides systems and methods for monitoring subjects, especially during sleep. Respiratory and sound data are recorded and coughs arousal are recognized as joint events in both of these signals having selected characteristics. Further, cough-arousal events during sleep are recognized when a likely cough occurs in association with a recognized EEG arousal. Cough arousal events are combined into a cough arousal index that reflects disease severity and sleep disruption due to cough. The methods of this invention are computer-implemented and can be provided as a program product including a computer readable medium. Measurements and indices provided by this invention can be used to monitor and to treat respiratory diseases.

Abstract: An intravitreal injection device for administering a pharmacological agent formulation to an intravitreal compartment of an eye, comprising (i) a nozzle member having an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein, (ii) a microneedle having a first end that is in communication with the nozzle member and a second ejection end, (iii) and piercing depth limiter means for limiting the penetration depth of the microneedle into the eye, the microneedle piercing depth limiter means including guide means for positioning the limiter means and guiding the microneedle.

Abstract: The invention comprises a gastric device having an outer region and a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.

Abstract: The present invention relates to the field of ambulatory and non-invasive monitoring of a plurality of physiological parameters of a monitored individual. The invention includes a physiological monitoring apparatus with an improved monitoring apparel worn by a monitored individual, the apparel having attached sensors for monitoring parameters reflecting pulmonary function, or parameters reflecting cardiac function, or parameters reflecting the function of other organ systems, and the apparel being designed and tailored to be comfortable during the individual's normal daily activities. The apparel is preferably also suitable for athletic activities. The sensors preferably include one or more ECG leads and one of more inductive plethysmographic sensor with conductive loops positioned closely to the individual to preferably monitor at least basic cardiac parameters, basic pulmonary parameters, or both.

Abstract: The invention comprises methods for noninvasively monitoring physiological characteristics of a patient's blood. Determinations of blood constituent concentrations may be made by comparing absorbance of radiation at varying parameters, such as path length and blood pressure. Preferably, changes in pressure are effected by changing the height of the probes relative to the patient's heart. Determinations of blood pH may be made by comparing absorbance of the blood at different wavelengths. The temperature of the blood, and thus of the patient's core, may also be accurately determined. Further, cardiac output characteristics and blood pressures may be noninvasively determined using the methods of the invention.