Patents Represented by Attorney Francis T. Kremblas, Foster, Millard & Pollick Kremblas
  • Patent number: 6146633
    Abstract: Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptide may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals' resistance to exogenous proteins, for example viral proteins.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 14, 2000
    Assignee: The Ohio State University
    Inventor: Vernon C. Stevens
  • Patent number: 6143305
    Abstract: Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptide may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals' resistance to exogenous proteins, for example viral proteins.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 7, 2000
    Assignee: The Ohio State University
    Inventor: Vernon C. Stevens
  • Patent number: 6096318
    Abstract: Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptide may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals' resistance to exogenous proteins, for example viral proteins.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 1, 2000
    Assignee: The Ohio State University
    Inventor: Vernon C. Stevens
  • Patent number: 6039948
    Abstract: Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptide may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals' resistance to exogenous proteins, for example viral proteins.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 21, 2000
    Assignee: The Ohio State University
    Inventor: Vernon C. Stevens
  • Patent number: 5891992
    Abstract: Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptides may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals resistance to exogenous proteins, for example viral proteins.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 6, 1999
    Assignee: The Ohio State University Research Foundation
    Inventor: Vernon C. Stevens
  • Patent number: 5817753
    Abstract: Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptides may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals resistance to exogenous proteins, for example viral proteins.
    Type: Grant
    Filed: October 6, 1992
    Date of Patent: October 6, 1998
    Assignee: The Ohio State University Research Foundation
    Inventor: Vernon C. Stevens
  • Patent number: 5782629
    Abstract: A porous surface radiant burner assembly provided with a porous burner substrate having a surface including a layer of zircon and an overlying layer of zirconia formed in situ upon exposing the zircon layer to radiant burner operating conditions. The porous surface burner substrate can be in the form of a mat of randomly oriented fibers coated with zircon, a solid parted plate of zircon or a different ceramic provided with a coating layer of zircon, or a reticulated foam comprising either zircon or a different ceramic material coated with zircon. Preferably in the method of making the porous burner substrate, the zircon layer is merely exposed to the intended operating conditions of the radiant burner wherein during the initial degradation of the zircon layer, a continuous, adherent layer of zirconia is formed in overlying relationship to the layer of zircon to resist further degradation.
    Type: Grant
    Filed: January 22, 1996
    Date of Patent: July 21, 1998
    Assignee: The Ohio State University
    Inventor: John J. Lannutti