Patents Represented by Attorney Francis T. Kremblas, Foster, Millard & Pollick Kremblas
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Patent number: 6146633Abstract: Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptide may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals' resistance to exogenous proteins, for example viral proteins.Type: GrantFiled: June 6, 1995Date of Patent: November 14, 2000Assignee: The Ohio State UniversityInventor: Vernon C. Stevens
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Patent number: 6143305Abstract: Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptide may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals' resistance to exogenous proteins, for example viral proteins.Type: GrantFiled: June 6, 1995Date of Patent: November 7, 2000Assignee: The Ohio State UniversityInventor: Vernon C. Stevens
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Patent number: 6096318Abstract: Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptide may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals' resistance to exogenous proteins, for example viral proteins.Type: GrantFiled: June 6, 1995Date of Patent: August 1, 2000Assignee: The Ohio State UniversityInventor: Vernon C. Stevens
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Patent number: 6039948Abstract: Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptide may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals' resistance to exogenous proteins, for example viral proteins.Type: GrantFiled: June 6, 1995Date of Patent: March 21, 2000Assignee: The Ohio State UniversityInventor: Vernon C. Stevens
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Patent number: 5891992Abstract: Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptides may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals resistance to exogenous proteins, for example viral proteins.Type: GrantFiled: June 6, 1995Date of Patent: April 6, 1999Assignee: The Ohio State University Research FoundationInventor: Vernon C. Stevens
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Patent number: 5817753Abstract: Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptides may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals resistance to exogenous proteins, for example viral proteins.Type: GrantFiled: October 6, 1992Date of Patent: October 6, 1998Assignee: The Ohio State University Research FoundationInventor: Vernon C. Stevens
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Patent number: 5782629Abstract: A porous surface radiant burner assembly provided with a porous burner substrate having a surface including a layer of zircon and an overlying layer of zirconia formed in situ upon exposing the zircon layer to radiant burner operating conditions. The porous surface burner substrate can be in the form of a mat of randomly oriented fibers coated with zircon, a solid parted plate of zircon or a different ceramic provided with a coating layer of zircon, or a reticulated foam comprising either zircon or a different ceramic material coated with zircon. Preferably in the method of making the porous burner substrate, the zircon layer is merely exposed to the intended operating conditions of the radiant burner wherein during the initial degradation of the zircon layer, a continuous, adherent layer of zirconia is formed in overlying relationship to the layer of zircon to resist further degradation.Type: GrantFiled: January 22, 1996Date of Patent: July 21, 1998Assignee: The Ohio State UniversityInventor: John J. Lannutti