Patents Represented by Attorney Frank R. Cottingham

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  • Cell culture compositions capable of producing a VEGF-binding fusion polypeptide
    Patent number: 8343737
    Abstract: The present invention provides cell culture compositions capable of producing fusion polypeptides that bind vascular endothelial growth factor (VEGF). The cell culture compositions of the invention comprise cells which contain an expression vector comprising a nucleic acid molecule encoding a fusion polypeptide that binds VEGF. The fusion polypeptides may comprise a VEGF receptor component having an immunoglobulin-like (Ig) domain 2 of a first VEGF receptor, an Ig domain 3 of a second VEGF receptor, and a multimerizing component.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: January 1, 2013
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Nicholas J. Papadopoulos, Samuel Davis, George D. Yancopoulos
  • High affinity human antibodies to human IL-4 receptor
    Patent number: 8337839
    Abstract: The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: December 25, 2012
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Joel H. Martin, Tammy T. Huang, Jeanette L. Fairhurst, Nicholas J. Papadopoulos
  • High affinity human antibodies to human IL-4 receptor
    Patent number: 8338135
    Abstract: An isolated human antibody or antigen binding fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R?) with an affinity constant (KD) of less than 200 pM, as measured by surface plasmon resonance, is provided.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: December 25, 2012
    Assignee: Regeneron Pharmaceuticals, inc.
    Inventors: Sean Stevens, Tammy T. Huang, Joel H. Martin, Jeanette L. Fairhurst, Ashique Rafique, Marcela Torres, Kevin J. Pobursky, Raymond W. Leidich, Joan A. Windsor, Warren R. Mikulka, Diana M. Ahrens, Ergang Shi, Nicholas J. Papadopoulos
  • High-affinity human antibodies to human protease-activated receptor-2
    Patent number: 8101724
    Abstract: The present invention provides antibodies that bind to protease-activated receptor-2 (PAR-2) and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human PAR-2. The antibodies of the invention are useful for the treatment of diseases and disorders associated with one or more PAR-2 biological activities, including the treatment of pain conditions, inflammatory conditions and gastrointestinal conditions.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: January 24, 2012
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Lynn MacDonald, Andrew J. Murphy, Nicholas J. Papadopoulos, Marc R. Morra, Robert R. Salzler, Michael L. LaCroix-Fralish
  • High affinity human antibodies to human IL-4 receptor
    Patent number: 7794717
    Abstract: The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: September 14, 2010
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Sean Stevens, Tammy T. Huang, Joel H. Martin, Jeanette L. Fairhurst, Ashique Rafique, Marcela Torres, Kevin J. Pobursky, Raymond W. Leidich, Joan A. Windsor, Warren R. Mikulka, Diana M. Ahrens, Ergang Shi, Nicholas J. Papadopoulos
  • Assay methods for detection of a virus in an avian tissue sample
    Patent number: 7524651
    Abstract: The invention relates to methods of detecting a virus in an avian tissue sample wherein genetic material derived from feathers is tested for the presence of genetic material from the virus.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: April 28, 2009
    Assignee: Wyeth
    Inventors: Venugopal K. Nair, Susan Jean Baigent, Richard John William Currie
  • Methods for preventing or ameliorating West Nile encephalitis
    Patent number: 7445787
    Abstract: The present invention provides a safe and effective vaccine composition against West Nile virus disease. An immunogenically active component of West Nile virus or plasmid DNA, an adjuvant such as a metabolizable oil, and a pharmacologically acceptable carrier are formulated into an immunizing vaccine. The invention also provides a method for the prevention or amelioration of West Nile disease, such as encephalitis, in equidae by administering the vaccine composition herein set forth.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: November 4, 2008
    Assignee: Wyeth
    Inventor: Hsien-Jue Chu
  • Methods and vaccines for providing in ovo protection against turkey rhinotracheitis
    Patent number: 7348012
    Abstract: Methods and compositions for protecting avian hosts (e.g., turkeys and/or chickens) from turkey rhinotracheitis virus and/or TRT or SHS respiratory distress utilize in ovo administration of live, avirulent strains of TRTV at appropriate dosage levels on a per egg basis to provide an effective and efficient vaccination having acceptable safety and efficacy features, and additionally provides higher titers in vaccinated birds than conventionally administered vaccines.
    Type: Grant
    Filed: October 17, 2005
    Date of Patent: March 25, 2008
    Assignee: Wyeth
    Inventor: Frans Gerrit Davelaar
  • Infectious bursal disease virus antigenic isolates and vaccines
    Patent number: 7338661
    Abstract: Antigenic isolates and vaccines for Infectious Bursal Disease Virus include variants of the molecular Group 6 family of IBDV isolates, in particular the 28-1 isolate.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: March 4, 2008
    Assignee: Wyeth
    Inventors: Jeffrey Harold Rodenberg, Mahesh Kumar, Kalen Cookson
  • Ovo immunization against infectious bronchitis
    Patent number: 7208164
    Abstract: The present invention is directed to processes and compositions for protecting host animals (e.g., chickens) from exposure to virulent infectious bronchitis virus. In ovo administration of live, avirulent strains of IB at appropriate dosage levels on a per egg basis provides an effective and efficient vaccination having acceptable safety and efficacy features.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: April 24, 2007
    Assignee: Wyeth
    Inventors: Berend Jongsma, Frans Gerrit Davelaar, Marinus Wynand Westrate
  • West nile vaccine
    Patent number: 7153513
    Abstract: The present invention provides a safe and effective vaccine composition against West Nile virus disease. An immunogenically active component of West Nile virus or plasmid DNA, an adjuvant such as a metabolizable oil, and a pharmacologically acceptable carrier are formulated into an immunizing vaccine. The invention also provides a method for the prevention or amelioration of West Nile disease, such as encephalitis, in equidae by administering the vaccine composition herein set forth.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: December 26, 2006
    Assignee: Wyeth
    Inventor: Hsien-Jue Chu