Patents Represented by Attorney Frank S. Chow

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  • 4,5-Dihydro-4,5-dioxo-1H-1-benzopyrano (2,3-B)-pyridine-3-carboxylic acids, salts and esters
    Patent number: 4117134
    Abstract: This invention relates to compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or lower alkyl; and the pharmaceutically acceptable, non-toxic salts thereof. The compounds of the invention are active in the prevention of allergic and asthmatic reactions in mammals.
    Type: Grant
    Filed: June 13, 1978
    Date of Patent: September 26, 1978
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Maximilian VON Strandtmann
  • Bronchodilating piperidinoethyl benzopyranopyridinones
    Patent number: 4117140
    Abstract: Disclosed are novel substituted benzopyranopyridines which are active as bronchodilators.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: September 26, 1978
    Inventors: Richard E. Brown, Chester Puchalski, John Shavel, Jr.
  • 1,2-Benzoxathiin-2,2,-dioxides
    Patent number: 4116961
    Abstract: Disclosed are substituted 1,2-benzoxathin-2,2-dioxide, and methods for their manufacture. These compounds show antiinflammatory activity.
    Type: Grant
    Filed: February 24, 1977
    Date of Patent: September 26, 1978
    Assignee: Warner-Lambert Company
    Inventors: Charles F. Schwender, Brooks R. Sunday
  • 6,7-Dimethoxy-2-(4-thiomorpholinyl)-4-quinazolinamine and related sulfoxide and sulfone
    Patent number: 4115565
    Abstract: Disclosed are a series of quinazoline derivatives which have activity as hypotensive agents.
    Type: Grant
    Filed: October 25, 1977
    Date of Patent: September 19, 1978
    Assignee: Warner-Lambert Company
    Inventors: Lawrence D. Wise, Glenn C. Morrison
  • Octapeptides and methods for their production
    Patent number: 4111923
    Abstract: New octapeptides having the formula Prot Grp-R-Trp-Ser-Tyr-R.sub.2 -Leu-Arg-Pro-R.sub.3 ; salts thereof; wherein R is Gln, Gln (bzl), His (bzl), Ser (bzl), Pro, Leu, Tyr (bzl), Ile, Cys (bzl) or Phe, R.sub.2 is D-Phe, D-Ala, D-Leu, D-Trp, D-Tyr, D-Tyr (Me), D-Ser, D-Met, D-Arg, D-Val, D-His, D-Gln, D-Phs, D-Thr, D-Pro, D-Me.sub.5 Phe or D-Asn and R.sub.3 is NH.sub.2, NH(lower alkyl), N-(lower alkyl).sub.2, NH-benzyl, NHCH.sub.2 CH.sub.2 N-(lower alkyl).sub.2 or NH-CH.sub.2 CH.sub.2 SO.sub.2 NH-benzyl; methods for their production; certain peptide intermediates and their salts used in the production thereof; and the use of said octapeptides as luteinizing hormone releasing factor antagonists.
    Type: Grant
    Filed: December 27, 1976
    Date of Patent: September 5, 1978
    Assignee: Parke, Davis & Company
    Inventors: Eugene Leroy Wittle, Mildred Catherine Rebstock, Ernest D. Nicolaides, Alfred Campbell
  • 3-(Thienyloxy)pyridines and methods for their production
    Patent number: 4111943
    Abstract: 3-(Thienyloxy)pyridines and acid-addition salts thereof, which are useful as pharmacological agents, especially in the area of psychostimulants, are disclosed. These compounds can be produced by reacting a halothiophene with a metallic salt of 3-hydroxypyridine.
    Type: Grant
    Filed: April 20, 1977
    Date of Patent: September 5, 1978
    Assignee: Warner-Lambert Company
    Inventor: Donald Eugene Butler
  • Antiarrhythmic (+,-)-cis-.alpha.-[3-(2,6-dimethyl-1-piperidinyl)propyl]-.alpha.-phenyl- 2-pyridinemethanols
    Patent number: 4112103
    Abstract: (+,-)-cis-.alpha.[3-(2,6-Dimethyl-1-piperidinyl)propyl]-.alpha.-phenyl-2-py ridinemethanol and acid-addition salts. The compounds are pharmacological agents, especially antiarrhythmic agents. The compounds can be produced by reacting pyridyllithium with cis-.gamma.-(2,6-dimethylpiperidino)butyrophenone, or by reacting cis-1-(3-lithiopropyl)-2,6-dimethylpiperidine with 2-benzoylpyridine. Pharmaceutical compositions comprising (+,-)-cis-.alpha.-[3-(2,6-dimethyl-1-piperidinyl)propyl]-.alpha.-phenyl-2- pyridinemethanol and acid-addition salts thereof and methods for treating cardiac arrhythmia using said pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: February 25, 1977
    Date of Patent: September 5, 1978
    Assignee: Parke, Davis & Company
    Inventor: Robert Willerton Fleming
  • Tricyclic sulphoximides in pharmaceutical compositions and methods
    Patent number: 4110448
    Abstract: The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistaminic, antitussive, antiinflammatory, sedative, and diuretic properties.
    Type: Grant
    Filed: August 31, 1976
    Date of Patent: August 29, 1978
    Assignee: Warner-Lambert Company
    Inventors: Peter Stoss, Gerhard Satzinger, Manfred Herrmann
  • Indolopyrones having antiallergic activity
    Patent number: 4110464
    Abstract: This invention relates to novel substituted indolopyrones which have utility in preventing allergic and asthmatic reactions in mammals.
    Type: Grant
    Filed: February 25, 1977
    Date of Patent: August 29, 1978
    Assignee: Warner-Lambert Company
    Inventors: Richard E. Brown, Paul C. Unangst
  • Dithio prostaglandin derivatives
    Patent number: 4110341
    Abstract: Prostaglandin analogues of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R.sup.1 represents a straight- or branched-chain alkyl group containing from 4 to 10 carbon atoms, and R.sup.2 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms and cyclodextrin clathrates of such acids and esters and, when R.sup.2 represents a hydrogen atom, non-toxic salts thereof, the bonds attaching the epidithio radical to the carbon atoms in the 9- and 11-positions in the grouping of formula VA being either botn in .alpha.-configuration or both in .beta.-configuration are disclosed.These compounds exhibit characteristic prostaglandin properties.
    Type: Grant
    Filed: February 4, 1977
    Date of Patent: August 29, 1978
    Assignee: Ono Pharmaceutical Company
    Inventors: Masaki Hayashi, Seiji Kori, Hajimu Miyake
  • 1-Nor-2-amino carbamates derived from acid S, an antibiotic produced by Polyangium cellulosum var. fulvum
    Patent number: 4107429
    Abstract: The present invention relates to 1-nor-2-amino carbamates derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The 1-nor-2-amino carbamates of acid S of this invention are useful as antifungal agents.
    Type: Grant
    Filed: February 4, 1977
    Date of Patent: August 15, 1978
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Samuel M. Ringel, Maximilian VON Strandtmann
  • 1,3,8-Trimethylimidazopyrazolodiazepine compounds
    Patent number: 4105851
    Abstract: 4-Aryl-1,6-dihydro-1,3,8-trimethylimidazo[1,2-a]-pyrazolo[4,3-f][1,4]diazep ines; and acid-addition salts. The aryl group is o-fluorophenyl or o-chlorophenyl. The compounds are pharmacological agents, especially anticonvulsant and antianxiety agents. They can be produced by reacting an aryl-(2-hydroxymethyl)-imidazol-1-yl-1,3-dimethylpyrazol-4-ylmethanone hydrocarbon sulfonate ester with ammonia in the presence of iodide.
    Type: Grant
    Filed: June 17, 1976
    Date of Patent: August 8, 1978
    Assignee: Parke, Davis & Company
    Inventor: Horace A. De Wald
  • Antiallergic pyrido[2,1-b]quinazolin-ones
    Patent number: 4104389
    Abstract: This invention relates to novel compounds of the pyrido-[2,1-b]quinazolin-one series and their methods of preparation. These compounds have utility as antiallergy agents.
    Type: Grant
    Filed: March 7, 1977
    Date of Patent: August 1, 1978
    Assignee: Warner-Lambert Company
    Inventors: Charles F. Schwender, Brooks R. Sunday
  • 1-Substituted-2-(2-pyridinyl)ethanone N-oxides
    Patent number: 4104274
    Abstract: 1-Substituted-2-(2-pyridinyl)ethanone N-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, or benzyloxy; R.sub.4 is halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho benzoylamino; and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy; the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof, are described. The compounds of this invention are useful for the treatment of allergic conditions and for the treatment of hyperacidity.
    Type: Grant
    Filed: August 16, 1977
    Date of Patent: August 1, 1978
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Patricia A. Young, Maximilian VON Strandtmann
  • Dibenzyl glycolic acid derivatives
    Patent number: 4104380
    Abstract: The present invention is concerned with new dibenzylglycolic acid derivatives and with the preparation thereof. These derivatives show an extraordinary anti-hypertensive and antisecretory profile.
    Type: Grant
    Filed: March 15, 1977
    Date of Patent: August 1, 1978
    Assignee: Warner-Lambert Company
    Inventors: Wolf-Dieter Vigelius, Gerhard Satzinger, Manfred Herrmann
  • Octapeptides and methods for their production
    Patent number: 4101537
    Abstract: New octapeptides having the formula X-R.sup.1 -Trp-Ser(benzyl)-Tyr(benzyl)-R.sup.2 -Leu-Arg(R)-Pro-R.sup.3 -Y wherein X is a protective group, R is hydrogen or a protective group, R.sup.1 is a single bond, Gln, D-Leu or D-Val, R.sup.2 is D-Phe or D-Ala, R.sup.3 is a single bond or Gly and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: April 7, 1977
    Date of Patent: July 18, 1978
    Assignee: Parke, Davis & Company
    Inventors: Ernest D. Nicolaides, Francis John Tinney
  • Novel antibacterial amide compounds and process means for producing the same
    Patent number: 4101661
    Abstract: Novel organic amide compounds which are N-[6-[(aminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl]penicillin and cephalosporin type compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or cephalosporin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponing N-6-[(aminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid, 7-aminocephalosporanic acid, 7-amino-3-methylceph-3-em-4-carboxylic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(aminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.
    Type: Grant
    Filed: June 3, 1977
    Date of Patent: July 18, 1978
    Assignee: Warner-Lambert
    Inventors: James S. Kaltenbronn, Theodore H. Haskell, Leonard Doub
  • Nonapeptides and methods for their production
    Patent number: 4101538
    Abstract: New nonapeptides having the formula R-Gln-Trp-Ser-Tyr-Trp-Pro-Pro-Tyr(benzyl)-Ser(benzyl)-Y wherein R is a protective group and Y is amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: June 13, 1977
    Date of Patent: July 18, 1978
    Assignee: Warner-Lambert
    Inventor: Alfred Campbell
  • Aldehyde, oxime and phenylhydrazone derivatives of acid S, an antibiotic produced by Polyangium cellulosum var. fulvum
    Patent number: 4098998
    Abstract: The present invention relates to aldehyde, oxime and phenylhydrazone derivatives of the novel antibiotic substance, acid S, produced by the organism Polyangium cellulosum var. fulvum (ATCC No. 25532) and to processes for their preparation. The aldehyde, oxime and phenylhydrazone derivatives of acid S of this invention are useful as antifungal agents.
    Type: Grant
    Filed: February 4, 1977
    Date of Patent: July 4, 1978
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Samuel M. Ringel, Maximillian Von Strandtmann
  • 3-Formylchromones
    Patent number: 4098799
    Abstract: Novel 3-formylchromone derivatives are disclosed, substituted on the 5,6,7, or 8 positions by one or more of the following substituents: halogen, hydroxy, lower alkyl, lower alkoxy, lower acyl, lower acyloxy, or methylenedioxy. The corresponding 3-acetal or 3-hydrazone derivatives of the carboxaldehyde group are also disclosed. These compounds, and pharmaceutical compositions containing these compounds are useful for the treatment of allergic conditions and for the treatment of hyperacidity.
    Type: Grant
    Filed: June 19, 1974
    Date of Patent: July 4, 1978
    Assignee: Warner-Lambert Company
    Inventors: Sylvester Klutchko, Daniel Kaminsky, deceased, Maximilian VON Strandtmann