Patents Represented by Attorney Fried, Frank, Harris, Shriver & Jacobson LLP
  • Patent number: 7883699
    Abstract: The invention provides methods to for treating a an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: February 8, 2011
    Assignee: Proteon Therapeutics, Inc.
    Inventor: F. Nicholas Franano
  • Patent number: 7632494
    Abstract: The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: December 15, 2009
    Assignee: Proteon Therapeutics, Inc.
    Inventor: F. Nicholas Franano
  • Patent number: 7361335
    Abstract: The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: April 22, 2008
    Assignee: Proteon Therapeutics, Inc.
    Inventor: F. Nicholas Franano
  • Patent number: 7153505
    Abstract: The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes preventively dilating a section of conduit to minimize the risk of obstruction formation.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: December 26, 2006
    Assignee: Proteon Therapeutics, Inc.
    Inventor: F. Nicholas Franano
  • Patent number: 7063838
    Abstract: The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes preventively dilating a section of conduit to minimize the risk of obstruction formation.
    Type: Grant
    Filed: September 24, 2000
    Date of Patent: June 20, 2006
    Assignee: Proteon Therapeutics LLC
    Inventor: Nicholas F. Franano
  • Patent number: 7042346
    Abstract: A system and method for collecting data relating to the parts of a vehicle and using such data to determine if the vehicle can be operated. The system entails the deployment of a plurality of radio frequency identification tags on or within various parts of the vehicle that are capable of issuing radio frequency signals containing data related to each corresponding part. A radio frequency transceiver capable of interfacing with and receiving data stored within each tag operates in conjunction with a central processor unit capable of analyzing the data from each tag and determining whether the vehicle needs parts to be replaced or can be operated with its existing set of parts.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: May 9, 2006
    Inventor: Gaige Bradley Paulsen
  • Patent number: 6999458
    Abstract: A telephony network for enabling the origination and termination of telephone calls between one or more subscriber terminals connected to a public packet network with an open addressing protocol and one or more non-subscriber terminals connected to a PSTN network. Subscribers to the telephony network have E.164 numbers mapped to their current IP address and published by a mapping server so other subscribers and non-subscribers can call the subscriber. The mapped information is published on either a HTML or XML page for direct use over the Internet by other subscribers or for use by a gateway device. The gateway device enables non-subscribers on the PSTN to directly call subscribers. Calls between subscribers completely by-pass the PSTN. Subscribers can also call anyone with a phone number whether they are a subscriber or not.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: February 14, 2006
    Assignee: theglobe.com
    Inventor: Brian Fowler