Patents Represented by Attorney, Agent or Law Firm Frishauf, Holz, Goodman, Langer & Chick, P.C.
  • Patent number: 6350462
    Abstract: An improved porous ceramic body to be embedded in a patient for sustained release of a medicament, and a method of making the ceramic body is provided. To control the release of the medicament, the pores of the ceramic body decrease in diameter from the inner surface to the outer surface of the body whereby the pore diameter is substantially proportional to the distance from the outer surface of the carrier. First, raw ceramic slurry is made from the blend of &bgr;-TCP, deflocculating agent, and water. Next, using a syringe the ceramic slurry is supplied to the internal region of a solvent-absorbable mold from an aperture along the inner wall surface. Then, the ceramic slurry is quickly dehydrated before thinly adhering itself onto the inner wall surface of the mold. Therefore, a preformed body having a hollow is obtained. Next, after fully being dried, the dried preformed body is fired at 1,050° C. for an hour before eventually yielding a spherical carrier for use in sustained release preparation.
    Type: Grant
    Filed: April 7, 1993
    Date of Patent: February 26, 2002
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Yasuharu Hakamatsuka, Hiroyuki Irie, Gen Horie