Abstract: A method for preparing fibrinogen-coated liposomes is disclosed. In this process, fibrinogen and an acylating agent are reacted in the presence of a dispersion of liposomes under specifically defined reaction conditions. The liposomes formed using this process, pharmaceutical compositions containing those liposomes, and the methods of clotting blood and delivering pharmaceutically-active agents and/or other chemicals utilizing those pharmaceutical compositions are also disclosed.
Type:
Grant
Filed:
March 31, 1995
Date of Patent:
August 19, 1997
Assignee:
University of Cincinnati
Inventors:
Gregory Scott Retzinger, Ashley P. Deanglis