Abstract: The present invention provides methods of treatment of adenoviral mediated disease, improved methods for transducing cells with adenoviral and related vectors, and improved methods of gene therapy utilizing such methods.
Type:
Grant
Filed:
February 14, 2003
Date of Patent:
December 5, 2006
Assignee:
Research Development Foundation
Inventors:
Saumya-Ray Chaudhuri, Mary Y. Hurwitz, Vien Holcombe, Karen T. Marcus, Richard L. Hurwitz
Abstract: The invention relates to a peptide with the sequence of RLLEFYLAM, methods for the use of the peptide, and antisera and monoclonal antibodies against the peptide. The peptide is derived from the NY-ESO-1 molecule, which form complexes with HLA molecules, leading to lysis of cells presenting these complexes, by cytolytic T lymphocytes.
Type:
Grant
Filed:
April 12, 2001
Date of Patent:
January 6, 2004
Assignee:
Ludwig Institute for Cancer Research
Inventors:
Ozlem Tureci, Ugur Sahin, Michael Pfreundschuh
Abstract: A flexible mechanical joint is disclosed for joining a first elongated structural section with a second elongated structural section. The joint is compressible and expandable at least along a substantially longitudinal direction upon movement of at least one of the first and second sections. The joint includes a first connecting portion fixedly attached to the first section and a second connecting portion fixedly attached to the second section. The joint also has a flexible member that connects the first connecting portion with the second connecting portion and is positioned between the two connecting portions. The flexible member is shiftable upon relative longitudinal movement between the first and second sections. At least one of the first and second connecting portions includes an anchoring member frictionally engaging one of the first and second sections and including a lip that is secured into the one section.
Type:
Grant
Filed:
February 22, 1999
Date of Patent:
December 11, 2001
Assignee:
Advanced Industrial & Marine Services
Inventors:
Randy W. Masters, Cecil M. Brandon, Jr.