Abstract: An active peptide consisting essentially of 7 to about 30 residue and having a sequence that corresponds to a conserved domain of an HIV protein is disclosed, as is a multimer containing that peptide, an aqueous composition containing the multimer and methods of using and making the same. The aqueous composition containing an immunologically effective amount of an active peptide multimer, when introduced into an immunocompetent host animal in an immunologically effective amount, is capable of inducing cellular immunity against the native HIV protein to which the active peptide of the multimer corresponds in sequence, but is not capable of inducing production of antibodies that immunoreact with that native HIV protein.
Type:
Grant
Filed:
February 13, 1992
Date of Patent:
July 24, 2001
Assignee:
The University of Texas System The Board of Regents
Abstract: Methods and materials for expressing and assaying functional neuronal receptors in neuronal cells, including methods for detecting particular odorant ligand specificity for particular odorant receptors and methods of using such. For example, methods and materials are provided for assaying for functional odor receptors in intact nasal epithelium of mammals such as rats and mice and for using such.
Abstract: An undersea hydraulic coupling is pressure balanced to reduce forces tending to urge the coupling members apart during coupling or uncoupling. A seal retainer having an L-shaped fluid passage is used to provide fluid communication between the radial fluid passage in the male member and the longitudinal fluid passage in the female member of the coupling. The seal retainer holds one or more radial seals in the female member upon disengagement of the male coupling member.