Abstract: The present invention concerns particular G-quartet oligonucleotides that are employed for the treatment and/or prevention of cancer. In specific cases, the G-quartet oligonucleotides inhibit HIF-1?.

Abstract: A messaging system and method for creating a messaging hierarchy in a computer network are described. The network is made up of multiple network entities, which include both publishing entities and subscribing entities, where the publishing entities have data of which the subscribing entities may have need. The messaging system and method for creating a messaging hierarchy also include a data hierarchy applied to the data exchanged between the publishing entities and subscribing entities. The data hierarchy determines the virtual connections formed between the network entities in response to publication and subscription requests exchanged between the entities, such that the virtual connections established between network entities form a hierarchy corresponding to the data hierarchy.

Abstract: The present invention provides for IgG1 molecules with improved characteristics. In particular, substitution mutations are provided that, in combination, facilitate improved placental transfer, improved serum half-life and improved FcRn binding. Substitution mutations are also provided, that in combination, can be used to block FcRn function and thereby increase the clearance rates of other (endogenous or exogenous) IgGs, block placental transport of IgGs and have increased affinity/reduced pH dependence for FcRn binding.

Abstract: Process for obtaining a hard coated article having anti-fouling properties, including, for example, an optical article such as an ophthalmic lens, comprising a substrate coated with a hard coating providing abrasion resistance and hardness and adhesion to the anti-fouling coating, and the article obtained from such process.

Abstract: The splicing variant D of the TAK1 gene is activated by short double-stranded RNAs in a sequence specific manner. Activation of TAK1-D leads to the downstream activation of the p38 MAPK and of SAPK/JNK but not the NF?B pathway. The current invention therefore provides a method of inducing apoptosis and/or cell cycle arrest in a cancer cell comprising contacting said cell with an agonist of Tak1-D function. The invention further provides a method of modulating inflammation and the treatment of cancer by the administration of an agonist of Tak1-D function or expression. In yet another aspect, the invention provides a method of inducing p38 MAPK and SAPK/JNK signaling in a cell comprising contacting said cell with an agonist of Tak1-D function or expression.

Abstract: A tissue processing system includes a series of blades arranged in parallel to form a tissue processor. The blades may be adjusted to create a spaced between each blade in the range of 250-1000 microns. A slicer is included to remove a donor tissue to be processed by the processor. The processor is rotatable 90 degrees so as to create uniform micrografts of tissue for transplanting to a recipient site. An extractor is included to remove tissue particles from the processor after they have been cut into an appropriate size. A cutting block may be provided to ensure uniform thickness of cuts of the donor tissue.

Abstract: A stent is coated with 3-deazaadenosine or an analog of 3-deazaadenosine for the prevention and/or treatment of vascular disease or graft rejection.

Abstract: Water-soluble sulfo group containing copolymers use as stabilizers, rheology modifiers and water retention agents in aqueous building materials based on hydraulic binders, such as cement, lime, gypsum and anhydrite, and in water-based painting and coating systems are described. Processes of preparing the copolymers and methods of using them are also described.

Abstract: Disclosed is a method of reducing the appearance of coloring streaks in a composition that has a colorant comprising adding a guar gum containing compound to said composition.

Abstract: An arrangement and a method are disclosed for driving and steering an engine driven vehicle of the type m which left and right hand wheels 120L, 120R are respectively driven from the engine through left and right hand transmissions 122L, 122R and a steering effect is exerted by changing the ratio of one transmission relative to the other. According to the invention a follower is operatively coupled to at least one of the transmissions and is movable circumferentially about an axis by means of a driver actuable steering control to change the relative speeds of the two driven wheels and radially with respect to the axis by means of a driver actuable speed control to increase/decrease the speeds of the two driven wheels in unison.

Abstract: A traveler can subscribe to a pick-up service (consolidator) that will pick-up purchases made at any number of different locations while the traveler is visiting a location, or series of locations. The consolidator then bundles all of the purchases from the various locations into appropriate sized packages for delivery to the traveler's desired location. The consolidator gathers the various purchases over a period of time and coordinates ultimate delivery to the traveler according to a pre-arranged itinerary of the traveler.

Abstract: A method for producing an article which is made of a transparent material and devoid of visible surfacing lines, comprising: obtaining a substrate which is made of a transparent material having a refractive index ns, at least one main face of which has been ground and polished in such a way that the Ra value thereof ranges from 0.001 to 0.1 ?m, but has visible surface defects in the form of thin individual scratches; depositing, a liquid polymerisable composition of a masking coating, the contact angle of which with said substrate main face being equal to or less than 30° and which forms upon polymerization a masking coating having a refractive index nc such that 0.01<|ns?nc|?0.15 and a thickness less than 10 micrometers, directly onto the ground and polished main face of the substrate, polymerizing the masking coating composition; and recovering the transparent article.

Abstract: Four zebrafish gene promoters, which are skin specific, muscle specific, skeletal muscle specific and ubiquitously expressed respectively, were isolated and ligated to the 5? end of the EGFP gene. When the resulting chimeric gene constructs were introduced into zebrafish, the transgenic zebrafish emit green fluorescence under a blue light or ultraviolet light according to the specificity of the promoters used. Thus, new varieties of ornamental fish of different fluorescence patterns, e.g., skin fluorescence, muscle fluorescence, skeletal muscle-specific and/or ubiquitous fluorescence, are developed.

Abstract: A multi-processor system comprises at least one host processor, which may comprise a fixed instruction set, such as the well-known x86 instruction set. The system further comprises at least one co-processor, which comprises dynamically reconfigurable logic that enables the co-processor's instruction set to be dynamically reconfigured. In this manner, the at least one host processor and the at least one dynamically reconfigurable co-processor are heterogeneous processors having different instruction sets. Further, cache coherency is maintained between the heterogeneous host and co-processors. And, a single executable file may contain instructions that are processed by the multi-processor system, wherein a portion of the instructions are processed by the host processor and a portion of the instructions are processed by the co-processor.

Abstract: The use of powder metal components in a variator is disclosed. Traction fluid of various sorts may be used in the variators, not just high performance synthetics or application specific lubricants.

Abstract: Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of human airway trees. Some of the devices and methods are particularly useful for matching branch-points of human airway trees from represented in two or more graphs.

Abstract: The present invention relates to an optical article comprising on one of the main surfaces thereof an external water- and/or oil-repellent coating, characterized in that a temporary coat of a dried polyurethane latex-based composition is directly deposited onto the external water- and/or oil-repellent coating.

Abstract: The present invention relates to a new tumor suppressor, designated FJX1. Also described are diagnostic, prognostic and therapeutic uses of the FJX1 protein and the FJX1 gene, alone or in combination with traditional cancer therapies.

Abstract: A wireless communication system can include polarization agile antennas to enable adaptation to the polarization characteristics of a changing propagation channel. In one embodiment, a mobile terminal can include one or more polarization-agile antennas, and can select polarization orientations that are preferentially propagated through the changing propagation channel. In another embodiment, a mobile terminal having two polarization-agile antennas can provide spatial diversity, polarization diversity, or combinations of both. Multiple-input multiple-output (MIMO) systems can include polarization-agile antennas to allow for switching between spatial and polarization diversity, combined spatial and polarization diversity, and various Eigen channel decompositions using spatial, polarization, and combined spatial and polarization dimensions. An extended polar normalization provides enhanced fidelity for methods of communications system modeling.

Abstract: The present invention provides monoclonal antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. Other antibodies inhibit both activated protein C and activation of unactivated protein C. Methods of treatment employing these antibodies are described herein as are methods of screening for and detecting these antibodies.