Patents Represented by Attorney G. A. Frank

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  • Immunoglobulin half-molecules and process for producing hybrid antibodies
    Patent number: 4479895
    Abstract: A process for preparing covalent hybrid antibodies is provided. These antibodies are obtained by the ordered covalent hybridization of intact immunoglobulin molecules. The generation of half-molecules from different IgG antibodies by reductive or S-sulfonation selective cleavage is followed by the ordered association of the different half-molecules. The pure covalent hybrid antibodies as new substances are also provided along with IgG half-molecules.
    Type: Grant
    Filed: May 5, 1982
    Date of Patent: October 30, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Karen Auditore-Hargreaves