Patents Represented by Attorney Gabriel Lopez
  • Patent number: 5861177
    Abstract: A process for the production of a dry pancreatin preparation is characterised in that the still moist pancreatin mass, which is obtained after extraction with a solvent or solvent mixture, is treated, before the solvents are finally removed, for a short time in a vacuum cutter, until the mass has been divided and shaped into small spherical particles, and then is finally dried.
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: January 19, 1999
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gunther Atzl, Franz Langer, Herbert Polleres
  • Patent number: 5856355
    Abstract: Non-greasy topical solutions, emulsion gels or lotions comprising as the active agent a compound of formula I ##STR1## and a lower alkanol, and if desired together with a solubilizing agent or an oil phase such as isopropyl myristate are useful delivery systems.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: January 5, 1999
    Assignee: Novartis Ag
    Inventors: Friedrich Richter, Michel Steiger
  • Patent number: 5856578
    Abstract: The present invention relates to a process for the preparation of aromatic amino compounds which are substituted by a least one group comprising at least one unsaturated carbon-carbon bond, by catalytic hydrogenation of corresponding aromatic nitro compounds in the presence of a modified noble metal catalyst, wherein the noble metal catalyst used is platinum modified with a metal selected from the group consisting of lead, mercury, bismuth, germanium, cadmium, arsenic, antimony, silver and gold, and to novel noble metal catalysts for use in this process.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: January 5, 1999
    Assignee: Norvartis Corporation
    Inventors: Urs Siegrist, Peter Baumeister
  • Patent number: 5849859
    Abstract: A biodegradable and biocompatible polyester comprising (C.sub.3-10) alkylene carbonic acid ester units, each alkylene group being a C.sub.3 -alkylene group having 1 oxy substituent or a (C.sub.4-10) alkylene group having 2-8 oxy substituents, each of the oxy substituents occurring individually as a hydroxyl group or as a derivatized hydroxyl group comprising an ester or an ortho ester or an acetal residue.The polyesters may be used as matrices for the sustained release of pharmacologically active compounds, e.g. peptides or proteins, in the form of microparticles or implants.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: December 15, 1998
    Assignee: Novartis AG
    Inventor: Murat Acemoglu
  • Patent number: 5849665
    Abstract: Herbicidal composition comprisingN-?2-(3,3,3-trifluoropropyl)-phenylsulfonyl!-N'-(4-methoxy-6-methyl-1,3,5-t riazin-2-yl)-urea of the formula I ##STR1## or agrochemically tolerated salts thereof, and a synergistic amount of another active substance 3,5-dibromo-4-hydroxybenzonitrile of the formula II ##STR2##
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 15, 1998
    Assignee: Novartis Corporation
    Inventors: Hans Gut, Wolfgang Paul Iwanzik, Martin Schulte
  • Patent number: 5846571
    Abstract: When used in admixture with mancozeb, chlorothalonil, a copper salt, folpet, fluazinam or cymoxanil (it being possible for the latter to be used also together with one of the other five components), metalaxyl having a high R-enantiomer content of more than 70% by weight, or pure R-metalaxyl, exhibits a markedly increased fungicidal action against plant diseases as compared with a similar mixture in which metalaxyl is used in the form of the racemate.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: December 8, 1998
    Assignee: Novartis Corporation
    Inventors: Cosima Nuninger, John Edward Nicholas Goggin, Dino Sozzi
  • Patent number: 5840730
    Abstract: Mixtures of certain triazole fungicides (component I) and 4,6-dimethyl-N-phenyl-2-pyrimidinamine (component II) achieve synergistically enhanced activity against fungus infestation. Components I and II can also be applied to plant crops individually, one immediately after the other.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: November 24, 1998
    Assignee: Novartis Corporation
    Inventors: Adolf Hubele, Ronald Zeun
  • Patent number: 5821288
    Abstract: A coating composition comprisinga) a film-forming materialb) a stabilizing effective amount of a light stabilizing composition which comprises a blend of at least one diphenyloxamine of the formula ##STR1## where R.sub.1 is hydrogen, alkyl, alkoxy or halogen;R.sub.2 is hydrogen, alkyl, alkoxy, halogen, phenyl or phenoxy; andR.sub.3 and R.sub.4 are hydrogen, alkyl or alkoxy and at least one selected tetraalkylpiperidine.In a preferred embodiment, a benzotriazole is also present in the light stabilizing composition.The coating compositions are especially useful for the automotive market.The invention further relates to a method for enhancing the light stability of coatings comprising adding to the solids content of the coating composition a stabilizing quantity of the above-mentioned light stabilizing composition. The invention also relates to the corresponding stabilized coating film.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: October 13, 1998
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Lajos Avar, Roland Joseph Valin
  • Patent number: 5814629
    Abstract: The invention relates to novel microbicidal and plant-immunising compounds of formula I ##STR1## wherein: X is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, SR.sub.8, N(R.sub.9)R.sub.10, CH.sub.2 OH, CHO or COOR.sub.8 ;R.sub.8 to R.sub.10 are hydrogen, C.sub.1 -C.sub.4 alkyl, benzyl, C.sub.1 -C.sub.4 acyl or benzoyl;Z is hydrogen, halogen, or a methyl group that is unsubstituted or to which from 1 to 3 unsubstituted or substituted hetero atoms O, S and/or N are bonded; in free form or in the form of salts. They can be used in crop protection for controlling and preventing disease infestation.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: September 29, 1998
    Assignee: Novartis Finance Corporation
    Inventors: Peter Stanetty, Walter Kunz
  • Patent number: 5807820
    Abstract: Pharmaceutical compositions comprising a cyclosoporin, e.g. Ciclosporin, and a mono- or poly-unsaturated fatty acid or alcohol, e.g. oleic acid or oleyl alcohol. The compositions are suitable for dermal application, e.g. in the treatment of autoimmune disease of the skin or for the promotion of hair growth.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: September 15, 1998
    Assignee: Novartis AG
    Inventor: Peter M. Elias
  • Patent number: 5780469
    Abstract: Plant-protecting active ingredient mixtures having synergistically enhanced action, wherein component I is a compound having plant-immunising action of formula I ##STR1## wherein Z is CN, COOH or a salt thereof, CO--OC.sub.1 --C.sub.4 alkyl or CO--SC.sub.1 --C.sub.4 alkyl;and wherein component II is a compound selected from the groupA) 4-?3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acryloyl!morpholine ("dimethomorph");B) 5-methyl-1,2,4-triazolo?3,4-b!?1,3!benzothiazole ("tricyclazole"); andC) 3-allyloxy-1,2-benzothiazole-1,1-dioxide ("probenazole").
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: July 14, 1998
    Assignee: Novartis Finance Corporation
    Inventor: Wilhelm Ruess
  • Patent number: 5780439
    Abstract: A whey protein hydrolysate is described which is free of allergenics while preserving the structures susceptible of exerting anticipatory regulations to maximize the tolerance and protein metabolism, and mixtures thereof with casein and/or soy protein hydrolysates. Whey protein hydrolysates according to the invention have an amino acid composition comprising at least 2% by weight of tryptophan, less than 5% by weight of threonine, less than 2.8% by weight of methionine whereby 40 to 60% by weight of the amino acids are in the form of tetra- to decapeptides.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: July 14, 1998
    Assignee: Novartis Nutrition AG
    Inventors: Francois Mendy, Jean-Maurice Kahn, Loic Roger
  • Patent number: 5766946
    Abstract: A monoclonal antibody that recognises a structurally continuous and extracellularly-located epitope of human P-glycoprotein is described. The monoclonal antibody has a continuous amino acid sequence, and a binding affinity for the P-glycoprotein which manifests in the ability to stain greater than 90% of live CEM-VBL10 cells in a flow cytometry assay.
    Type: Grant
    Filed: December 15, 1994
    Date of Patent: June 16, 1998
    Assignee: Instituto Superiore Di. Sanita'
    Inventor: Maurizio Cianfriglia
  • Patent number: 5764539
    Abstract: A non-invasive system and method is provided for a fluid delivery system of the type including a fluid delivery pump delivering fluid in pulses through a fluid delivery tube. The non-invasive monitoring system and method includes a sensor which is brought into engagement with an outer surface of the fluid delivery tube. The sensor is adapted for being calibrated at an initial temperature and is responsive to the fluid when passing through the fluid delivery tube. In particular, the present system and method is adapted to monitor the sensor and receives data corresponding to the changes in the initial temperature of the sensor as influenced by the temperature of the fluid when passing through the fluid delivery tube. The non-invasive monitoring system and method is further adapted to process the data from the sensor indicative of both the initial and changed temperatures for determining the status of the fluid in the fluid delivery tube.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: June 9, 1998
    Assignee: Novartis Nutrition AG
    Inventor: Robert G. Rani
  • Patent number: 5750548
    Abstract: The compounds of formula I are described ##STR1## wherein Hal is halogen, such as fluorine, chlorine, bromine or iodine;R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.7 cycloalkyl;R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.7 cycloalkyl, andR.sub.3 is hydrogen or C.sub.1 -C.sub.6 alkyl,for use in a method of controlling fleas in domestic animals, especially in dogs and cats, wherein systemic administration is preferred. The compounds of formula I are administered in an amount effective against fleas via the digestive tract or via the blood of the host animal and thus systemically to the domestic animal, especially the dog or the cat.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: May 12, 1998
    Assignee: Novartis Corp.
    Inventors: Thomas Friedel, Eric William Moyses, Olivier Tinembart, Peter Maienfisch, Laurenz Gsell
  • Patent number: 5747657
    Abstract: The invention relates to reactive-group-containing monoazo dyestuffs of formula (I), their salts or mixtures thereof, wherein R.sub.1 signifies hydrogen, methyl, methoxy or ethoxy, R.sub.2 signifies hydrogen, methyl, NHCONH.sub.2 or NHCOCH.sub.3, RG signifies (a), (b) or (c), X signifies hydrogen or chlorine, Z signify a group --CH=CH.sub.2, --CH.sub.2 CH.sub.2 W or mixtures thereof wherein W is a leaving group removable by alkali and --SO.sub.2 --Z may be bonded in a meta- or para-position with respect to the azo group. These compounds are useful as reactive dyestuffs in printing or dyeing hydroxy-group-containing or nitrogen-containing organic substrates.
    Type: Grant
    Filed: January 14, 1997
    Date of Patent: May 5, 1998
    Assignee: Clariant Finance (BVI) Limited
    Inventor: Friedrich Lehr
  • Patent number: 5733569
    Abstract: Pharmaceutical compositions for nasal administration comprising i) a calcitonin, and ii) benzalkonium chloride, and/or iv) a surfactant, suitable for application to the nasal mucosa, in iii) a liquid diluent or carrier, suitable for application to the nasal mucosa. The compositions are suitably adapted for administration in the form of a nasal spray.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 31, 1998
    Assignee: Novartis Corporation
    Inventors: Moise Azria, Thomas Cavanak
  • Patent number: 5731422
    Abstract: Complexes of formulae I and II ##STR1## wherein the variables are as defined in the specification are useful as dyes for, for example, the mass dyeing of plastics and for lacquers.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 24, 1998
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Bansi Lal Kaul, Dominique Pflieger
  • Patent number: 5725599
    Abstract: A process for the production of mineral tanned or/and re-tanned or/and after-treated leather or pelt, wherein before the mineral tanning, directly after the mineral tanning, directly before the mineral re-tanning, after the mineral re-tanning or/and with the after-treatment of a fatliquoring with a polyvalent metal cation, the substrate is treated with(A) a polymeric carboxylic acid containing .alpha.-hydroxyacrylic acid units, optionally in salt form, as constituent units of the polymer,by which a high exhaustion of mineral (re)tanning agent, an excellent distribution of the tanning agent and very pleasant soft handle of the (re)tanned leather resp. an outstanding water resistance of mineral after-treated fat-liquored leather can be achieved.
    Type: Grant
    Filed: March 20, 1995
    Date of Patent: March 10, 1998
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Bernard Danner, Eckardt Hauser, Jurg Heller, Heribert Schmitz, Andre Vallotton
  • Patent number: D411801
    Type: Grant
    Filed: January 7, 1997
    Date of Patent: July 6, 1999
    Assignee: Novartis AG
    Inventors: J. Ross Kinneir, Graeme L. J. Paterson