Abstract: A transgenic non-human aquatic organisms, such as piscine, crustacea, mollusks, and the like, having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such organisms and nucleic acid sequences encoding GDF-8 polypeptides from such aquatic organisms.
Type:
Grant
Filed:
August 19, 1999
Date of Patent:
October 15, 2002
Assignee:
The John Hopkins University School of Medicine
Abstract: A head suspension assembly for use in a magnetic disk drive includes a magnetic head constituted by a magnetoresistive element for reading data and a head element for writing data, a slider for holding the magnetic head above a surface of a rotating magnetic recording medium, a suspension for supporting the slider, and a head integrated circuit mounted on the suspension. The head integrated circuit having a built-in protection circuit electrically connected with the magnetoresistive element to protect the magnetoresistive element from electrostatic breakdown. Thereby, the magnetic head can be efficiently prevented from suffering electrostatic breakdown due to, e.g., electrostatic discharge occurring during the assembly process of incorporating the head suspension assembly into the magnetic disk drive.
Abstract: Disclosed is a process for forming a normalized genomic DNA library from an environmental sample by (a) isolating a genomic DNA population from the environmental sample; (b) at least one of (i) amplifying the copy number of the DNA population so isolated and (ii) recovering a fraction of the isolated genomic DNA having a desired characteristic; and (c) normalizing the representation of various DNAs within the genomic DNA population so as to form a normalized library of genomic DNA from the environmental sample. Also disclosed is a normalized genomic DNA library formed from an environmental sample by the process.
Abstract: A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be used for the removal of arginine, phenylalanine, or methionine amino acids from the N-terminal end of peptides in peptide or peptidomimetic synthesis. The enzyme is selective for the L, or `natural` enantiomer of the amino acid derivatives and is therefore useful for the production of optically active compounds. These reactions can be performed in the presence of the chemically more reactive ester functionality, a step which is very difficult to achieve with nonenzymatic methods.
Type:
Grant
Filed:
April 24, 1998
Date of Patent:
November 16, 1999
Assignee:
Diversa Corporation
Inventors:
Dennis Murphy, John Reid, Dan Robertson