Abstract: The invention provides a system for compensating for hard sector noise degradation of tracking error signals in an optical data storage system. The system includes a hard sector detection circuit which generates a first output signal in response to receiving a first input signal representing detection of a hard sector on a magneto-optical disk; a logic circuit which generates a second output signal in response to receiving the first output signal and a second input signal; and a tracking error signal reconstruction circuit which generates an approximated tracking error signal in response to receiving a tracking error signal and the second output signal. The invention may be embodied as hardwired circuitry or as a combination of hardware and software embodied in a computer readable medium and implemented in a digital computer.

Abstract: A data storage subsystem employs managed files comprising one or a contiguous aggregation of multiple constituent user files. A mapping table cross-references each managed file with the names and locations of its constituent user files. A storage table cross-references each managed file with its address. Eventually, "deleted-file space" arises as individual user files are deleted from managed files. "Reconstruction" consolidates managed files to regain this wasted space. Reconstruction preferably permits multiple embodiments of a managed file called "siblings". Reconstruction identifies contiguous regions of user files within a managed file, and copies these regions to adjacent locations in a target area. Before entering the reconstructed file in any tables, the mapping table is searched for a "paradigm" managed file containing the same user files as the reconstructed file.

Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides includeNH.sub.2 -KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1)andNH.sub.2 -KWKSFIKKLTSAAKKVVTTAKPLISS-COOH. (SEQ ID NO:2)Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.

Abstract: A combined read head and write head includes at least one write coil layer embedded in an insulation stack. The insulation stack is sandwiched between first and second pole piece layers that are connected at a back gap. The pole piece layers have first and second pole tips that have edges that form a portion of an air bearing surface. A write gap layer that forms a portion of the air bearing surface is sandwiched between a top surface of the first pole tip and a bottom surface of the second pole tip. A non-magnetic electrically conductive layer on top of the second pole tip forms a portion of the air bearing surface. A magnetoresistive sensor is sandwiched between first and second gap layers, which are sandwiched between first and second shield layers. The second shield layer is a common layer with the first pole piece layer.

Abstract: Growth differentiation factor-3 (GDF-3) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-3 polypeptide and polynucleotide sequences.

Abstract: A weight-bearing apparatus such as a cushion, prosthetic device or bed mattress includes a support surface having a shaped or sculpted portion that conforms to the shape of a body portion being supported. The shaped portion fits to the body portion, thereby to position the body portion so as to situate one or more weight-bearing parts of the body portion over specific zones of the support surface that are cooled below normal body temperature. The reduced temperature applied to the zones of the support surface removes heat from the weight-bearing areas, thereby reducing, the risk of injury to tissue in those areas.

Abstract: A transgenic mouse whose genome comprises a disruption of the endogenous growth differentiation factor-11 (GDF-11) gene is disclosed. Also disclosed are methods for making such mice. The mice exhibit a phenotype of increased muscle tissue.

Abstract: Disclosed are compositions and methods for their use, such as in identifying G-protein coupled receptors and ligands and compounds that modulate signal transduction. The compositions and methods employ promicuous G-proteins. Activation of the promiscous G-protein can be detected in a variety of assays, including assays in which activation is indicated by a change in fluorescence emission of a sample that contains the composition.

Abstract: Disclosed is a process for forming a normalized genomic DNA library from an environmental sample by (a) isolating a genomic DNA population from the environmental sample; (b) at least one of (i) amplifying the copy number of the DNA population so isolated and (ii) recovering a fraction of the isolated genomic DNA having a desired characteristic; and (c) normalizing the representation of various DNAs within the genomic DNA population so as to form a normalized library of genomic DNA from the environmental sample. Also disclosed is a normalized genomic DNA library formed from an environmental sample by the process.

Abstract: Compositions and methods for the modulation of melanin production are provided in which the active component is an adenosine receptor antagonist or agonist.

Abstract: The present invention is a method and apparatus for conveniently and removably sealing inlet ports within an inflatable thermal blanket. In accordance with the present invention a generally planar sheet of material having a plurality of resilient side extensions extending from a central body is used to close an inlet port within an inflatable thermal blanket. In accordance with the preferred invention, the generally circular portion of the central body has a diameter which is slightly smaller than the diameter of the inlet port. Preferably, for extensions extend from the central body each extension being generally circular. Each extension is preferably formed from the same material used to form the central body, and is sufficiently resilient to be easily flexed and to return to an essentially coplanar sheet when released.

Abstract: This invention includes a path-based method and system that restore a distributed telecommunications network (90) from a failure condition (92). First, the method and system notify all the network nodes (22, 24, 26, 28) of the fault of a link (12). Next, an alternate route finding phase occurs for finding alternate paths (S-T1-T4-D) to reroute the disrupted traffic. For finding alternate paths (S-T1-T4-D), the alternate route finding phase includes sending messages (70, 100) throughout the distributed telecommunications network. Upon finding some alternate paths (S-T1-T4-D), the method and system send connect commands (100) to make the necessary cross connections in the distributed telecommunications network nodes (22, 24, 26, 28) that are on the alternate paths (S-T1-T4-D). Throughout the distributed network restoration process, the method and system synchronize (62) the distributed telecommunications network nodes to avoid possible race conditions among the nodes.

Abstract: A system and method for indexing a data record from an information source into a database, the database containing a plurality of data records, is provided comprising receiving a data record from an information source, the received data record having a predetermined number of fields containing information about a particular entity, standardizing and validating the data in the received data record. A system and method is also provided for retrieving records that refer to an entity characterized by a specific set of data values by comparing a predetermined number of fields within the received data record with a predetermined number of fields within the data records already in the database, selecting data records already in the database as candidates having data within some of the predetermined fields that is identical to the data in the fields of the received data record, and scoring the candidates to determine data records having information about the same entity.

Abstract: A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be used for the removal of arginine, phenylalanine, or methionine amino acids from the N-terminal end of peptides in peptide or peptidomimetic synthesis. The enzyme is selective for the L, or `natural` enantiomer of the amino acid derivatives and is therefore useful for the production of optically active compounds. These reactions can be performed in the presence of the chemically more reactive ester functionality, a step which is very difficult to achieve with nonenzymatic methods.

Abstract: A method is provided for resetting the magnetization of the pinned and hard biasing layers of a spin valve read head at the row level. In a first embodiment of the invention a first magnetic field is applied substantially perpendicular to the air bearing surface (ABS) at room temperature for setting the magnetic moment of the pinned layer substantially perpendicular to the ABS followed by applying a second magnetic field substantially parallel to the ABS for setting the magnetic moments of the hard biasing layers substantially parallel to the ABS. In a second embodiment of the invention the antiferromagnetic pinning layer is also reset. This is done by heating the pinning layer with a current pulse conducted through the leads to the conductive layers of the spin valve head so that localized heating takes place adjacent the pinning layer as contrasted to ambient heating of the spin valve head.

Abstract: In accordance with the present invention, it has been discovered that conductive traces made from transient liquid phase sintering (TLPS) pastes, plated by electroless or electrolytic means, result in improved solderability, adhesion and conductivity of the circuitry. Transient liquid phase sintering pastes employed in the practice of the present invention differ from conventional metal loaded polymer thick film (PTF) inks in that they contain, in addition to a binder, they also contain both a relatively high melting metal powder and a relatively low melting solder powder capable of forming a continuous intermetallic/metallic phase after sintering. The present invention is particularly useful, for example, for the fabrication of single and multi-layer printed circuit boards, providing horizontal and vertical conductive interconnects, metallized through-holes, and conductive pads for electronic component attachment.

Abstract: In accordance with the present invention, there are provided methods for the separation of biological materials employing a variety of polymeric materials with defined chemical, physical and mechanical properties. Thus, a wide range of biological materials (i.e., from very low to very high molecular weight) can be separated according to the present invention. Polymeric materials contemplated for use in the practice of the present invention are block copolymers of partially hydrolyzed acrylonitrile which have excellent storage stability, are chemically inert, contain minimal residual concentration of monomeric species, and can be prepared in large scale.

Abstract: A magnetron sputtering system is provided that uses cooling channels in the magnetron assembly to cool the target. The magnetron sputtering system also generates low pressure region in the magnetron assembly such that the backing plate sees a pressure differential much lower than atmospheric pressure. The backing plate is reduced in thickness and provides less of a barrier to the generated magnetic field.

Abstract: A low inductance magnetic write head is provided with first and second pole piece layers that have first ends separated by a write gap layer and second ends connected together at a back gap. An insulation stack is provided which is sandwiched between the first and second pole piece layers. A write coil layer and a second coil layer are provided wherein each coil layer has inner and outer ends. The coil layers wind in the same direction from their inner ends to their outer ends. Each of the coil layers has first and second layer portions. The first layer portion of the write coil layer is embedded in the insulation stack. The second pole piece layer is sandwiched between the first portion of the write coil and a non-magnetic layer and the first non-magnetic layer is sandwiched between the second pole piece layer and the first portion of the second coil layer.

Abstract: Servo elements contained within a tape head detect a lateral displacement the magnetic tape relative to the tape head and generate position error signals corresponding to such lateral displacement. To aid in servo monitoring, the position error signals are sampled at predetermined times and the samples output or stored in machine-readable form. Each sample is classified as bad if it exceeds a predetermined threshold. Samples are analyzed to determine, for each time a bad position error signal occurs, how many successive position error signals are also bad. Samples are also analyzed to determine the relationship between bad position error signals samples and total samples. This data may be used for a number of different purposes. For example, this information may be used to identify differences between performance on top and bottom servo edges, or problems with the servo writing mechanism. Performance variations among different servo elements may also be identified.