Patents Represented by Attorney, Agent or Law Firm Gary M. Pace
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Patent number: 5882851Abstract: New cytochrome P-450 dependent monooxygenases and DNA molecules encoding these monooxygenases are provided, which are able to catalyze the biosynthetic pathway from amino acids to their corresponding cyanohydrins, the presursors of the cyanogenic glycosides, or to glucosinolates. Moreover, the invention provides methods for obtaining DNA molecules according to the invention and methods for obtaining transgenic plants resistant to insects, acarids, or nematodes or plants with improved nutritive value.Type: GrantFiled: August 8, 1996Date of Patent: March 16, 1999Assignees: Novartis Finance Corporation, Royal Veterinary Agricultural UniversityInventors: Birgit Maria Koch, Ole Sibbesen, Barbara Ann Halkier, Birger Lindberg M.o slashed.ller
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Patent number: 5880333Abstract: The present invention is drawn to a method of controlling gene expression in plants. Specifically, the method comprises obtaining a transgenic plant comprising at least two receptor expression cassettes and at least one target expression cassette. The first receptor expression cassette comprises a nucleotide sequence for a 5' regulatory region operably linked to a nucleotide sequence which encodes a first receptor polypeptide, and a 3' termination region. The second receptor expression cassette comprises a nucleotide sequence for a 5' regulatory region operably linked to a nucleotide sequence which encodes a second receptor polypeptide, and a 3' termination region.Type: GrantFiled: January 21, 1998Date of Patent: March 9, 1999Assignee: Novartis Finance CorporationInventors: Stephen A. Goff, Lyle D. Crossland, Laura S. Privalle
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Patent number: 5877012Abstract: The present invention is drawn to a novel class of proteins, and their receptors. Novel processes, assays and methods for controlling plant pests are provided.Type: GrantFiled: April 3, 1997Date of Patent: March 2, 1999Assignee: Novartis Finance CorporationInventors: Juan J. Estruch, Cao-Guo Yu, Gregory W. Warren, Nalini M. Desai, Michael G. Koziel, Gordon J. Nye
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Patent number: 5872212Abstract: The present invention is drawn to pesticidal strains and proteins. Bacillus strains which are capable of producing pesticidal proteins and auxiliary proteins during vegetative growth are provided. Also provided are the purified proteins, nucleotide sequences encoding the proteins and methods for using the strains, proteins and genes for controlling pests.Type: GrantFiled: June 6, 1995Date of Patent: February 16, 1999Assignee: Novartis Finance CorporationInventors: Gregory W. Warren, Michael G. Koziel, Martha A. Mullins, Gordon J. Nye, Brian Carr, Nalini M. Desai, Kristy Kostichka
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Patent number: 5866326Abstract: The present invention is drawn to pesticidal strains and proteins. Bacillus strains which are capable of producing pesticidal proteins and auxiliary proteins during vegetative growth are provided. Also provided are the purified proteins, nucleotide sequences encoding the proteins and methods for using the strains, proteins and genes for controlling pests.Type: GrantFiled: June 6, 1995Date of Patent: February 2, 1999Assignee: Novartis Finance CorporationInventors: Gregory W. Warren, Michael G. Koziel, Martha A. Mullins, Gordon J. Nye, Brian Carr, Nalini M. Desai, Kristy Kostichka, Nicholas B. Duck, Juan J. Estruch
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Patent number: 5859336Abstract: DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-preferred promoters are also provided. Additionally disclosed are transformation vectors comprising said DNA sequences. The transformation vectors demonstrate high levels of insecticidal activity when transformed into maize.Type: GrantFiled: June 2, 1995Date of Patent: January 12, 1999Assignee: Novartis CorporationInventors: Michael G. Koziel, Nalini M. Desai, Kelly S. Lewis, Gregory W. Warren, Stephen V. Evola, Lyle D. Crossland, Martha S. Wright, Ellis J. Merlin, Karen L. Launis, Cindy G. Bowman, John L. Dawson, Erik M. Dunder, Gary M. Pace, Janet L. Suttie
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Patent number: 5849870Abstract: The present invention is drawn to pesticidal strains and proteins. Bacillus strains which are capable of producing pesticidal proteins and auxiliary proteins during vegetative growth are provided. Also provided are the purified proteins, nucleotide sequences encoding the proteins and methods for using the strains, proteins and genes for controlling pests.Type: GrantFiled: June 5, 1995Date of Patent: December 15, 1998Assignee: Novartis Finance CorporationInventors: Gregory W. Warren, Michael G. Koziel, Martha A. Mullins, Gordon J. Nye, Brian Carr, Nalini M. Desai, Kristy Kostichka, Nicholas B. Duck, Juan J. Estruch
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Patent number: 5840868Abstract: The present invention is drawn to pesticidal strains and proteins. Bacillus strains which are capable of producing pesticidal proteins and auxiliary proteins during vegetative growth are provided. Also provided are the purified proteins, nucleotide sequences encoding the proteins and methods for using the strains, proteins and genes for controlling pests.Type: GrantFiled: June 6, 1995Date of Patent: November 24, 1998Assignee: Novartis Finance CorporationInventors: Gregory W. Warren, Michael G. Koziel, Martha A. Mullins, Brian Carr, Nalini M. Desai, Kristy Kostichka
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Patent number: 5824542Abstract: The present invention provides a dual method for producing male-sterile plants. Two genetically transformed plants, parents 1 and 2 are crossed to obtain male-sterile offspring. Parent 1 is transformed with an expression cassette comprising a nucleotide sequence encoding an anther-specific promoter which is operably linked to a nucleotide sequence encoding a transactivator. Parent 2 is transformed with an expression cassette comprising a target nucleotide sequence, which is capable of being activated by the transactivator, operably linked to a nucleotide sequence which encodes RNA or a polypeptide which will disrupt the formation of viable pollen. Therefore, crossing parent 1 with parent 2 results in male-sterile offspring. The male-sterile plants are useful for producing hybrid seed.The invention also provides compositions and methods for high level expression of a coding region of interest in a plant.Type: GrantFiled: May 23, 1995Date of Patent: October 20, 1998Assignee: Novartis Finance CorporationInventors: Lyle D. Crossland, Annmarie Tuttle, Jeffrey I. Stein
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Patent number: 5824302Abstract: According to the invention there is provided a method of controlling insect larvae comprising the steps of feeding said larvae an insecticidal amount of a transgenic Zea mays plant that expresses a polypeptide having the insect toxicity properties of Bacillus thuringiensis crystal protein.Type: GrantFiled: December 17, 1996Date of Patent: October 20, 1998Assignee: Novartis Finance CorporationInventors: Gleta Carswell, Christian Harms, Yin-Fu Chang, Mary-Dell Chilton
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Patent number: 5792925Abstract: DNA sequences are able to function as promoters of tissue-preferential transcription of associated DNA sequences in plants, particularly in the roots. These DNA sequences can be used in transformation vectors to produce transgenic plants which will express the heterologous genes preferentially in tissue, particularly in the roots of maize plants.Type: GrantFiled: May 25, 1995Date of Patent: August 11, 1998Assignee: Novartis Finance CorporationInventor: Annick J. de Framond
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Patent number: 5770696Abstract: The present invention is drawn to pesticidal strains and proteins. Bacillus strains which are capable of producing pesticidal proteins and auxiliary proteins during vegetative growth are provided. "The auxiliary proteins enhance the insecticidal activity of pesticidal proteins." Also provided are the purified proteins, nucleotide sequences encoding the proteins and methods for using the strains, proteins and genes for controlling pests.Type: GrantFiled: June 6, 1995Date of Patent: June 23, 1998Assignee: Novartis CorporationInventors: Gregory W. Warren, Michael G. Koziel, Martha A. Mullins, Gordon J. Nye, Brian Carr, Nalini M. Desai, Kristy Kostichka, Nicholas B. Duck, Juan J. Estruch
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Patent number: 5770450Abstract: Methods of regenerating fertile Zea mays plants from protoplasts or protoplast-derived cells are described. The protoplasts or cells may be derived from embryogenic cell cultures or callus cultures. The protoplasts, cells and resulting plants may be transgenic, containing, for example, chimeric genes coding for a polypeptide having substantially the insect toxicity properties of the crystal protein produced by Bacillus thuringiensis.Type: GrantFiled: July 1, 1994Date of Patent: June 23, 1998Assignee: Novartis Finance CorporationInventors: Ray Shillito, Gleta Carswell, Christian Harms, Yin-Fu Chang
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Patent number: 5766900Abstract: Methods of regenerating fertile Zea mays plants from protoplasts or protoplast-derived cells are described. The protoplasts or cells may be derived from embryogenic cell cultures or callus cultures. The protoplasts, cells and resulting plants may be transgenic, containing, for example, chimeric genes coding for a polypeptide having substantially the insect toxicity properties of the crystal protein produced by Bacillus thuringiensis.Type: GrantFiled: April 7, 1995Date of Patent: June 16, 1998Assignee: Novartis CorporationInventors: Ray Shillito, Gleta Carswell, Christian Harms, Yin-Fu Chang
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Patent number: 5695928Abstract: The present invention is drawn to an immunoassay capable of the rapid detection of a variety of test substances that may be present in a test sample. One feature of the invention is that extraction or isolation of the test substance occurs simultaneously with the formation of the primary antigen-test substance complex. The primary antigen-test substance complex is then captured in a solid phase format having a plurality of interstitial spaces which facilitate rapid and efficient detection. The immunoassay of the present invention works over a wide range of environmental conditions and is simple enough to be used in the absence of laboratory facilities.Type: GrantFiled: November 22, 1994Date of Patent: December 9, 1997Assignee: Novartis CorporationInventor: Sandy J. Stewart
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Patent number: 5686600Abstract: Antibodies, monoclonal antibodies or fragments thereof which bind to brush border membrane vesicles of insect gut and the gene or genes which encode these proteins are provided. The monoclonal antibodies bind the gut of a target insect but do not bind to mammalian brush border membranes or to plant microsomes. The antibodies and the genes encoding them find use in constructing hybrid toxins for control of insect pests.Type: GrantFiled: May 16, 1995Date of Patent: November 11, 1997Assignee: Novartis Finance CorporationInventors: Nadine B. Carozzi, Michael G. Koziel
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Patent number: 5659124Abstract: The present invention provides a dual method for producing male-sterile plants. Two genetically transformed plants, parents 1 and 2 are crossed to obtain male-sterile offspring. Parent 1 is transformed with an expression cassette comprising a nucleotide sequence encoding an anther-specific promoter which is operably linked to a nucleotide sequence encoding a transactivator. Parent 2 is transformed with an expression cassette comprising a target nucleotide sequence, which is capable of being activated by the transactivator, operably linked to a nucleotide sequence which encodes RNA or a polypeptide which will disrupt the formation of viable pollen. Therefore, crossing parent 1 with parent 2 results in male-sterile offspring. The male-sterile plants are useful for producing hybrid seed.The invention also provides compositions and methods for high level expression of a coding region of interest in a plant.Type: GrantFiled: January 3, 1995Date of Patent: August 19, 1997Assignee: Novartis CorporationInventors: Lyle D. Crossland, Annmarie Tuttle, Jeffrey I. Stein
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Patent number: 5646157Abstract: The present invention relates to a process of disposing obsolete planting seed treated with seed-protectant coatings, especially coatings comprising captan or any of the other widely used compounds such as, for example, pirimiphos-methyl and thiram, alone or in combination with other fungicidally or even insecticidally active compounds, which process comprises subjecting the said plant seed to a compostation.Type: GrantFiled: June 7, 1995Date of Patent: July 8, 1997Assignee: Novartis CorporationInventor: Kaspar J. Hohl
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Patent number: 5641666Abstract: The present invention discloses DNA molecules comprising a gene encoding yeast acetyl-coenzyme A carboxylase resistant to soraphen A inhibition. Mutations confering soraphen A resistance to acetyl-CoA carboxylase can be dominant or recessive, and they can be point mutations, deletion or insertion mutations. In addition methods of isolating a gene encoding fungal acetyl-coenzyme A carboxylase resistant to soraphen A inhibition are provided as well as methods for purifying fungal acetyl-coenzyme A carboxylase resistant to soraphen A inhibition. Purified enzyme can be used in assays to identify inhibitors of soraphen A resistant acetyl-coenzyme A carboxylase.Type: GrantFiled: December 13, 1994Date of Patent: June 24, 1997Assignee: Novartis CorporationInventors: Hans-Friedrich Vahlensieck, Albert Hinnen
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Patent number: 5610044Abstract: The present invention relates to a method for enhancing colonization of desired microorganisms in a localized environment comprising introducing into said localized environment a genetically engineered microorganism comprising a gene comprising a DNA sequence coding for one or more substrate utilizing protein, wherein said substrate utilizing protein confers a competitive effective ability to utilize a substrate by a microorganism in which it is genetically engineered, as well as the isolated genes and the genetically engineered microorganisms of such a method.Type: GrantFiled: November 29, 1994Date of Patent: March 11, 1997Inventors: Stephen T. Lam, Nancy R. Torkewitz, Chandra S. Nautiyal, Patrice Dion