Patent number: 6750205
Abstract: The present invention provides novel macrolide compounds of the formulas
wherein:
R is hydroxyl or methoxy;
R1 is selected from the group consisting of hydrogen, hydroxyl, halide, NH2, OR9,
where R9 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or heteroaryl and R10 and R11 are each independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or aryl;
R2 and R3 are each independently selected from the group consisting of hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, alkylaryl, alkenylaryl alkynylaryl or R2 and R3 together form a cycloalkyl or a cycloaryl moiety;
R4 is hydrogen or methyl;
R5 is hydrogen, hydroxyl, oxo, or together with R6 and the carbons to which they are attached form a cyclic carbonate;
R6 is hydrogen, hydroxyl, OR12 where R12 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or together with R5 and the carbons to which they are attached form a cyclic carbonate;
R7 is methyl, C3-C10 alkyl, C2-C10 alkenyl, C2-C10 alkyn
Type:
Grant
Filed:
April 7, 2003
Date of Patent:
June 15, 2004
Assignee:
Kosan Biosciences, Inc.
Inventors:
Gary Ashley, Mark Burlingame, Christopher Carreras, Daniel Santi