Patents Represented by Attorney, Agent or Law Firm Genencor Intl. Inc.
  • Enzymes which dehydrate glycerol
    Patent number: 6803218
    Abstract: The present invention relates to improved methods and reagents for the production of 1,3-propanediol. In particular, the present invention provides novel thermophilic organisms and thermostable enzymes cable of catalyzing the fermentation of glycerol to 1,3-propanediol. The present invention also relates to methods of isolating such thermophilic organisms, methods of cloning polynucleotides that encode such enzymes, polynucleotides encoding such enzymes, and methods of using such enzymes and organisms for the production of 1,3-propanediol.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: October 12, 2004
    Assignee: Genencor Intl., Inc.
    Inventors: Markus Seyfried, Juergen Wiegel, Gregory Whited
  • Alpha/beta hydrolase-fold enzymes
    Patent number: 6316241
    Abstract: The present invention relates to the identification of novel hydrolases in gram positive microorganisms. The present invention provides amino acid sequences for the hydrolase. The present invention provides host cells which comprise nucleic acid encoding the hydrolase. The present invention also provides cleaning compositions, animal feeds and compositions used to treat a textile that include the hydrolase of the present invention.
    Type: Grant
    Filed: July 20, 1999
    Date of Patent: November 13, 2001
    Assignee: Genencor International, Inc.
    Inventor: David A. Estell
  • Multiply-substituted protease variants
    Patent number: 6312936
    Abstract: Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance.
    Type: Grant
    Filed: October 23, 1998
    Date of Patent: November 6, 2001
    Assignee: Genencor International, Inc.
    Inventors: Ayrookaran J. Poulose, Volker Schellenberger, James T. Kellis, Jr., Christian Paech, Joanne Nadherny, Donald P. Naki, Katherine D. Collier, Robert M. Caldwell, André C. Baeck
  • High alkaline serine protease
    Patent number: 6287841
    Abstract: New PB92 or Subtilisin 309 mutant serine proteases are provided having specific mutations, resulting in an surprisingly better wash performance or in an improved storage stability with at similar or even better wash performance. These PB92 or Subtilisin 309 mutants include mutations at positions 60, 87, 97, 99, 102, 116, 117, 126, 127, 128, 130, 133, 134, 154, 156, 158, 159, 160, 164, 169, 175, 180, 182, 193, 197, 198, 203, 211, and 216. The new proteases, therefore, are very suitable for use in various types of detergents, whether or not in conjunction with other enzymes, for example amylases, cellulases and lipases. Preferred embodiments are the PB92 and Subtilisin 309 mutants having a mutation at position 102 and in particular those having at least one further mutation.
    Type: Grant
    Filed: July 27, 1993
    Date of Patent: September 11, 2001
    Assignee: Genencor International, Inc.
    Inventors: Leonardus Johannes Sofie Marie Mulleners, Onno Misset, Jan Metske Van Der Laan, Franciscus Josephus Cornelius Van Gastel, Cornelis Petrus Broekhuizen, Erik Jan Baas
  • Increasing production of proteins in gram-positive microorganisms
    Patent number: 6258563
    Abstract: The present invention relates to secretion in Gram-positive microorganisms. The present invention provides the nucleic acid amino acid sequences for the Bacillus subtilis secretion factors SecDF. The present invention also provides improved methods for the secretion of heterologous or homologous proteins in gram-positive microorganisms.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: July 10, 2001
    Assignee: Genencor International, Inc.
    Inventor: Wilhelmus J. Quax