Abstract: A method and apparatus for measuring a biological attribute, such as the concentration of an analyte, particularly a blood analyte in tissue such as glucose. The method utilizes spectrographic techniques in conjunction with an improved instrument-tailored or subject-tailored calibration model. In a calibration phase, calibration model data is modified to reduce or eliminate instrument-specific attributes, resulting in a calibration data set modeling intra-instrument or intra-subject variation. In a prediction phase, the prediction process is tailored for each target instrument separately using a minimal number of spectral measurements from each instrument or subject.
Type:
Grant
Filed:
August 16, 2002
Date of Patent:
August 29, 2006
Assignee:
InLight Solutions, Inc.
Inventors:
Michael J. Haas, Robert K. Rowe, Edward V. Thomas