Patents Represented by Attorney Genomics Institute of the Novartis Research Foundation
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Patent number: 7423031Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases and disorders associated with kinase activity, particularly diseases associated with the activity of CDK1, CDK2, CDK4, CDK5, GSK3?, Bcr-ab1, Flt-3, c-Kit, PDGFR?, Src, Mek1 and CK1.Type: GrantFiled: April 30, 2004Date of Patent: September 9, 2008Assignee: IRM LLCInventors: Yongqin Wan, Nathanael Schiander Gray
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Patent number: 7422411Abstract: The present invention provides grasping mechanisms, gripper apparatus/systems, and related methods. Grasping mechanisms that include stops, support surfaces, and height adjusting surfaces to determine three translational axis positions of a grasped object are provided. In addition, grasping mechanisms that are resiliently coupled to other gripper apparatus components are also provided.Type: GrantFiled: September 6, 2006Date of Patent: September 9, 2008Assignee: IRM LLCInventors: Robert Charles Downs, Mark Richard Weselak, James Kevin Mainquist
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Patent number: 7423038Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders than involve abnormal activation of the Abl, Bcr-abl, Bmx, c-RAF, CSK, Fes, FGFR3, Flt3, GSK3?, IR, JNK1? 1, JNK2? 2, Lck, MKK4, MKK6, p70S6K, PDGFR?, Rsk1, SAPK2?, SAPK2?, Syk and Trk? kinases.Type: GrantFiled: June 23, 2005Date of Patent: September 9, 2008Assignee: IRM LLC (a Delaware Limited Liability Corporation)Inventors: Pingda Ren, Xia Wang, Nathanael Schiander Gray, Yi Liu, Taebo Sim
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Patent number: 7417065Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.Type: GrantFiled: May 19, 2004Date of Patent: August 26, 2008Assignee: IRM LLCInventors: Yuan Mi, Shifeng Pan, Nathanael Schiander Gray, Wenqi Gao, Yi Fan, Tao Jiang
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Patent number: 7396910Abstract: This invention provides novel genes and polypeptides of the transient receptor potential channel family, and use of these genes and polypeptides for the treatment of pain and identification of agents useful in the treatment of pain.Type: GrantFiled: March 20, 2006Date of Patent: July 8, 2008Assignees: IRM LLC, Novartis AGInventors: Stuart Bevan, Pamposh Ganju, Peter McIntyre, Ardem Patapoutian, Andrea Peier, Chuanzheng Song
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Patent number: 7390458Abstract: Briefly, the present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work perimeters to facilitate robotic transfer of sample holders from one work perimeter to another area. Each work perimeter typically includes a plurality of defined station locations, with each station location positioned to be accessible by the robot associated with that area. In addition, each station location is typically configured to receive a device, such as an automated instrument or a holding nest. Device components are arranged at selected station locations according to specific application requirements to provide a flexible, robust, reliable, and accurate high throughput processing system.Type: GrantFiled: October 15, 2001Date of Patent: June 24, 2008Assignee: IRM LLCInventors: Kristina Marie Burow, Jeremy S. Caldwell, Robert Charles Downs, Scott Allan Lesley, James Kevin Mainquist, Andrew J. Meyer, Daniel G. Sipes, Mark Richard Weselak
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Patent number: 7384970Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.Type: GrantFiled: March 23, 2004Date of Patent: June 10, 2008Assignee: IRM LLCInventors: Hong Liu, Phil Alper, Arnab Chatterjee, David Tully, Badry Bursulaya, David Woodmansee, Robert Epple, Jennifer Leslie Harris, Jun Li
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Patent number: 7371750Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.Type: GrantFiled: July 29, 2004Date of Patent: May 13, 2008Assignee: IRM LLCInventors: Taebo Sim, Hyun Soo Lee, Pingda Ren, Qiang Ding, Guobao Zhang, Yi Liu, Xia Wang, Tetsuo Uno, Bing Li, Lintong Li, Nathanael Schiander Gray, Shuli You
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Patent number: 7364907Abstract: Methods and systems for sorting compounds and compound holders into batches for subsequent processing are provided.Type: GrantFiled: November 7, 2003Date of Patent: April 29, 2008Assignee: IRM LLCInventors: Mark R. Weselak, Brad Backes, Jared Ek
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Patent number: 7344833Abstract: This invention provides novel AP-1 modulatory polypeptides. The invention also provides methods for screening modulators of AP-1 transcription factor activities. The methods comprise first screening test agents for modulators of an AP-1-modulatory polypeptide and then further screening the identified modulating agents for modulators of AP-1 transcription factor activities. The invention further provides methods and pharmaceutical compositions for modulating AP-1 transcription factor activities in a cell and for treating diseases and conditions mediated by abnormal cellular proliferation.Type: GrantFiled: November 5, 2003Date of Patent: March 18, 2008Assignee: IRM LLCInventors: Sumit Chanda, Suhaila White, John B. Hogenesch, Jeremy S. Caldwell
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Patent number: 7335487Abstract: This invention provides novel genes and polypeptides of the sweet receptor family, methods for production of the polypeptides, methods for screening compounds that specifically bind to and/or modulate the activity of these polypeptides; and antibodies specific for the polypeptides.Type: GrantFiled: September 17, 2002Date of Patent: February 26, 2008Assignees: IRM LLC, The Scripps Research InstituteInventors: Jiayu Liao, Sheng Ding, Peter G. Schultz
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Patent number: 7329393Abstract: This invention provides capacity altering devices that facilitate the processing of samples whose volume exceeds the capacity of external sample processing regions (e.g., sample tubes or wells). The invention also provides holders that can be used with such devices, e.g., to allow centrifugation of the devices and/or to minimize handling of the external processing regions. Methods of processing samples, particularly samples whose volume exceeds the capacity of the external processing regions, and methods of collecting compounds in external processing regions are another feature of the invention.Type: GrantFiled: October 8, 2003Date of Patent: February 12, 2008Assignee: IRM LLCInventors: Bradley J. Backes, Jim Chang, John Isbell, James K. Mainquist, Christopher M. Shaw
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Patent number: 7329394Abstract: The invention provides an efficiently automated incubation device that reduces the number of powered moving parts in the device and the amount of air transfer between environments that are internal and external to the device.Type: GrantFiled: July 18, 2002Date of Patent: February 12, 2008Assignee: IRM LLCInventors: Mark R. Weselak, Robert C. Downs
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Patent number: 7314872Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula I: wherein Q is morpholinyl; and A, R5, R6, R7, R8, R9 and Ar are substituents.Type: GrantFiled: August 18, 2004Date of Patent: January 1, 2008Assignee: IRM LLCInventors: Hong Liu, Arnab Chatterjee, David C. Tully, Phillip Alper, Badry Bursulaya, Jianhua Guo, David H. Woodmansee, Daniel Mutnick, Donald S. Karanewsky, Yun He
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Patent number: 7307095Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.Type: GrantFiled: January 5, 2007Date of Patent: December 11, 2007Assignee: IRM LLCInventors: Hong Liu, David Tully, Phillip Alper, Robert Epple, Arnab Chatterjee, Michael Roberts
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Patent number: 7297714Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.Type: GrantFiled: October 20, 2004Date of Patent: November 20, 2007Assignee: IRM LLCInventors: Hong Liu, Phillip Alper, Daniel Mutnick, Donald Karanewsky
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Patent number: 7256206Abstract: The present invention relates to bicyclic derivatives, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG/S1P receptor mediated signal transduction.Type: GrantFiled: February 11, 2004Date of Patent: August 14, 2007Assignee: IRM LLCInventors: Shifeng Pan, Nathanael S. Gray, Yuan Mi, Wenqi Gao, Yi Fan, Sophie Lefebvre
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Patent number: 7256207Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.Type: GrantFiled: August 18, 2004Date of Patent: August 14, 2007Assignee: IRM LLCInventors: Hong Liu, Phillip B. Alper, Donald S. Karanewsky
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Patent number: 7252944Abstract: This invention provides methods for identifying novel SHMT modulators. The methods comprise first screening test agents for modulators of p38 activity and then further screening the identified modulating agents for modulators of SHMT enzyme activity. The invention further provides methods and pharmaceutical compositions for modulating cellular proliferation and for treating tumors using the novel SHMT modulators.Type: GrantFiled: July 30, 2004Date of Patent: August 7, 2007Assignee: IRM LLCInventors: Kavita Shah, Sungjoon Kim
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Patent number: 7253166Abstract: The invention provides a novel class of compounds and compositions of Formula I: in which R1, R2 and R3 are defined herein, that are useful in the treatment or prevention of diseases or disorders associated with kinases, particularly GSK-3?, c-Abl, HER-1, HER-2, KDR, Flt-3, c-Raf-1, PDGFR-?, c-Kit, Flt-4, Flt-1, Tek, c-src, CDK1, PDK1, FGFR-1, FGFR-2, Fer, MAP3K13, EPHA7 and c-Met kinases. The invention further relates to the use of the compounds of the invention as potent inducers of neurogenesis in embryonic stem cells.Type: GrantFiled: April 22, 2004Date of Patent: August 7, 2007Assignees: IRM LLC, The Scripps Research InstituteInventors: Sheng Ding, Tom Wu, Nathanael S. Gray, Peter Schultz