Abstract: There are disclosed new biological active polypeptides:A--X--Bwherein A is deamino-LYS or LYS; X is a suitable neutral aliphatic amino acid residue; e.g., one selected from the group consisting of SER, ALA, 2-Me-ALA, GLY, LEU, THR, D-SER, D-ALA, D-THR, allo-THR, D-LEU, and SAR; B is GLN-R', decarboxy-GLN, or ##STR1## and R' is a substituent which does not substantially affect the biological activity of the tripeptide.These polypeptides have the capability of inducing the differentiation of T-lymphocytes as measured by the acquisition of the thymic differentiation antigen Th-1, as well as B-lymphocytes as measured by the acquisition of the differentiation antigen Bu-1. The polypeptides are thus useful in thymic function and immunity areas such as in treatment for congenital absence of thymus. Also provided are therapeutic compositions and methods for use of the polypeptides.

Abstract: Improved fluspirilene-containing compositions for intramuscular administration and a method of preparing the same.

Abstract: A quantitative method and composition for precipitating fibrin monomers from plasma in the presence of fibrinogen, with only a small amount, if any, of fibrinogen being precipitated. A buffered precipitating agent is provided having a pH in the range of 6.5.+-.0.5, the buffer being one having a pKa in the range of 6 to 7 and protamine sulfate at a level of 0.025 to 0.2% by weight. Suitable buffers are 2-(N-morpholino)ethanesulfonic acid, sodium phosphate, histidine, maleic acid and imidazole. Analysis of the amount of fibrin present can be made by analyzing for protein using preferably a basic urea solution containing sodium hydroxide and measuring the absorbance at 282 nanometers.

Abstract: A drug-dispensing device and method for controlled and prolonged internal administration of medicaments to warm-blooded animals comprising an outer polymer envelope containing an expanding agent, drug metering means, and the drug itself. The outer polymer envelope is permeable to both the drug and body fluids and expands when the expanding agent is contacted by body fluids when the device is in the environment of use (e.g., the stomach). This expansion maintains the device in the environment of use while the drug is administered by the metering means.

Abstract: Substituted thioindoles and their sulfoxide and sulfone derivatives, useful as cardiac rate lowering agents and for other pharmacological properties, and precursors therefor.

Abstract: A chemically defined, protein-free culture medium embodying an anion-exchange resin and a water-soluble lipid source provides means for tissue culture.

Abstract: Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds, useful for their anti-inflammatory activity.

Abstract: The compound 2,3-diphenyl-5-ethyl-pyrazine, useful as a precursor in the synthesis of those compounds of the class of pyrazine, arylpyrazine, diphenylpyrazine, and cycloalkylpyrazine malonates, acetates, acetamides, and acetic acids, useful for their ultraviolet light absorption properties.

Abstract: A dental appliance for removal of liquid from the mouth and for containment of solid debris which comprises a flat, flexible, generally hour glass-shaped shield attached to a bite block on one end. A suction tube for fluid removal connects with a system of suction channels within the shield terminating in apertures along only the edge of the shield. The appliance is placed in the mouth so that the narrow central portion of the shield is over the gum behind the subject lower tooth, the portion adjacent the bite block is on the lingual side thereof, the portion remote from the bite block is on the buccal side thereof, and the edge containing the suction apertures is lowermost.

Abstract: Compounds of the class of 4-oxo-2-imidazolidinylidene ureas and 4-oxo-2-hexahydropyrimidinylidene ureas, useful as anti-secretory agents and central nervous system (CNS) depressants.

Abstract: Polishing compositions for highly filled resin-bonded dental restorations comprising a dispersion of alumina having a particle size less than about 3.0 microns and for nonprecious metal used in dental construction comprising a dispersion of said alumina and diamond having a particle size at least equal to that of the alumina but less than about 3.0 microns.

Abstract: Alkali metal and ammonium salts of crosslinked phosphonoalkyl cellulose are described which have a phosphorous content of from about 1.5% to about 4.0% by weight and a degree of crosslinking sufficient to make the modified cellulose salts essentially insoluble in aqueous media. These crosslinked phosphonoalkyl cellulose salts have significantly increased fluid absorption capacities as compared to unmodified cellulose and may be incorporated alone or in combination with other absorbent materials into catamenial tampons, sanitary napkins, diapers, and like absorbent devices.

Abstract: A process for rearranging .alpha.-acyl pyrroles to .beta.-acyl pyrroles which comprises reacting the former with an excess of a strong, anhydrous, non-oxidizing acid, preferably with heating.