Abstract: Optically active derivatives of glycidol are disclosed. These compounds, (2S) and (2R) glycidyl tosylate and (2S) and (2R) glycidyl 4-chloro-3-nitrobenzenesulfonate can be readily crystallized to high enantiomeric purity. Their use in other synthesis reactions is also described.
Type:
Grant
Filed:
October 1, 1986
Date of Patent:
August 7, 1990
Assignee:
Massachusetts Institute of Technology
Inventors:
Karl B. Sharpless, Janice M. Klunder, Tetsuo H. Onami