Abstract: This invention relates to Compounds of formula II: ##STR1## wherein Y is formyl, carboxylic acid, acrylic acid, cyano or tetrazolo; X is hydrogen, lower alkanoyl or lower alkyl, and their non-toxic, pharmaceutically acceptable salts are disclosed. These compounds are useful in the prevention of allergic and asthamatic reactions.

Abstract: Tetrahydropyridylbutyrophenones of the following formula I: ##STR1## wherein x is hydrogen, halogen such as fluorine, chlorine, bromine or iodine, trifluoromethyl, alkoxy, thioalkoxy, nitro, cyano, amino, lower alkyl of 1 to 6 carbons, aryl or substituted aryl; and y is hydrogen or halogen; and the non-toxic, pharmaceutically acceptable acid addition salts thereof. The compounds of the invention having the formula I are useful in the treatment of psychotic disorders such as schizophrenia.

Abstract: Tetrahydropyridylbutyrophenones of the following formula IX: ##STR1## wherein x is hydrogen, halogen such as fluorine, chlorine, bromine or iodine, trifluoromethyl, alkoxy, nitro, cyano, amino, lower alkyl of 1 to 6 carbons, aryl or substituted aryl; y is hydrogen or halogen; and n is 0, 1 or 2; and the non-toxic, pharmaceutically acceptable acid addition salts thereof. Tetrahydropyridylbutanols having the formula X: ##STR2## wherein x and y are as defined above, as well as their non-toxic, pharmaceutically acceptable acid addition salts, are also disclosed. The compounds of the invention having the formulas IX and X are useful as antipsychotics.

Abstract: A new and chemically unique one-pot process for the preparation of thiazolidin-4-one-acetic acid derivatives of the general formula: ##STR1## wherein R.sub.1 is a lower alkyl radical.

Abstract: Amino-substituted imidazo[1,2-a:3,4-a']diquinolin-15-ium salts having the formula I: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, C.sub.4 -C.sub.6 cycloalkyl, di(lower alkyl)amino, 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, methyl-1-pyrrolidinyl, methyl-1-piperidinyl, 4-morpholinyl or 2,2-dimethylhydrazino;R.sub.2 is hydrogen, lower alkyl, lower alkylamino, di(lower alkyl)amino, C.sub.4 -C.sub.6 cycloalkylamino, lower alkoxy(lower alkyl)amino, 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, methyl-1-pyrrolidinyl, methyl-1-piperidinyl, hexahydro-1H-azepin-1-yl, 4-morpholinyl, benzylamino, N-methylbenzylamino or 2-phenylethylamino;R.sub.3 is hydrogen or methyl;X is an anion;with the proviso that at least one of R.sub.1 and R.sub.2 is other than hydrogen, lower alkyl or C.sub.4 -C.sub.6 cycloalkyl; and with the further proviso that when R.sub.2 is dimethylamino, at least one of R.sub.1 and R.sub.3 is other than hydrogen, and intermediates used in the preparation thereof are disclosed.

Abstract: The present invention is concerned with new 3-pyrrolin-2-one derivatives which exhibit anti-hypertensive and vasodilatory action and with the preparation thereof.

Abstract: A process for the preparation of cis-(.+-.)-3,4-dihydro-N,N,2-trimethyl-2H-1-benzopyran-3-amine (I), a known antidepressant, is disclosed. The process of the invention is a multi-step process starting with 2-methyl-2H-1-benzopyran (II), which involves the production of novel intermediates (2.alpha.,3.beta.,4.alpha.)-(.+-.)-3,4-dihydro-2-methyl-4-(methylamino)-2H -1-benzopyran-3-ol (IV) and its hydrogen sulfate ester (V) as well as (1a.alpha.,2.beta.,7b.alpha.)-(.+-.)-1,1a,2,7b-tetrahydro-1,2-dimethyl[1]b enzopyrano[3,4-b]azirine (VI) and cis-(.+-.)-3,4-dihydro-N,2-dimethyl-2H-1-benzopyran-3-amine (VII). In the final step of the process, compound VII is methylated to form compound I.

Abstract: A process for the preparation of 1-hydroxyaporphine derivatives of the general formula: ##STR1## wherein R.sub.1, R.sub.3 and R.sub.4, which are the same or different, are lower alkyl, aryl or aralkyl radicals or R.sub.3 and R.sub.4 can together form a lower alkylene bridge member and R.sub.2 is a hydrogen atom or a lower alkyl, aralkyl or alkoxycarbonyl radical or an acyl radical derived from an aliphatic, aromatic or araliphatic carboxylic acid.

Abstract: This invention relates to a method for the removal of heparin from heparin-containing blood plasma test samples using an insoluble protamine reaction product, without adversely affecting subsequent testing of the plasma for clotting time. Protamine sulfate or a combination of protamine sulfate and serum albumin is cross-linked with glutaraldehyde to form an insoluble reaction product which is capable of adsorbing heparin. According to the method of this invention, excess amounts of either of the cross-linked protamine reaction products are added to blood plasma samples containing heparin and the mixture is agitated for a time sufficient to permit adsorption of substantially all heparin present. The insoluble protamine heparin complex formed is removed from the plasma along with any excess insoluble protamine reaction product. Aliquots of the heparin-free plasma may be subjected to coagulation tests in order to determine true clotting time.

Abstract: The present invention relates to 1,5-dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine- 3-carboxamides having the following structural formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl or nitro and R.sub.2 is hydrogen or lower alkyl.These compounds and their pharmaceutically acceptable salts are useful in the management of allergic manifestations such as bronchial asthma, hay fever and the like.

Abstract: This invention relates to a tableted form of fibrous triethylaminoethyl cellulose suitable for the removal of heparin from heparin-containing blood plasma. The tablet is composed of granular microcrystalline cellulose and fibrous triethylaminoethyl cellulose in a ratio of from about 5.4:1 to about 10:1. According to the method of this invention, the triethylaminoethyl cellulose tablet, which is formulated to provide from about 5 to about 26 mg. of triethylaminoethyl cellulose per milliliter of plasma sample, is added to a heparin-containing blood plasma sample, the sample is agitated or allowed to stand for a time sufficient to permit adsorption of substantially all heparin present. The sample is then centrifuged and the remaining heparin-free plasma can be subjected to coagulation testing in order to determine the true clotting time.

Abstract: An immunoassay for the sandwich technique is disclosed in which antibody (or antigen) is bound to a plastic strip, and after reaction with a test sample and then fluorescently tagged antibody (or antigen), fluorescense is read directly from the plastic strip in a fluorometer.

Abstract: 3-cyanochromones having the following structural formula I: ##STR1## wherein R represents hydrogen, halogen or lower alkoxy, are prepared by dehydrating chromone-3-carboxamides with thionyl chloride in N,N-dimethylformamide. The compound having formula I is useful as an anti-allergic and anti-secretory agent.

Abstract: The present invention relates to diacyloxyacids derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The diacyloxyacids derivatives of acid S of this invention are useful as antifungal and antibacterial agents.

Abstract: A two-stage process for the preparation of a chewing gum base utilizing solid elastomer is described wherein the solid elastomer is initially subjected to high intensity mixing under high shear conditions to masticate the solid until a substantially uniform, lump-free mass is obtained; followed by the step-wise addition of an elastomer solvent and an oleaginous plasticizer with continuous high intensity mixing until a substantially molten, uniform mass is obtained. In the second stage of the process, the remaining chewing gum base ingredients are added, step-wise, with continuous high intensity mixing until a uniform blend of ingredients is obtained. The second stage ingredients, which may include a non-toxic vinyl polymer, a hydrophobic plasticizer, additional oleaginous plasticizer and an emulsifier, are added step-wise in a sequence determined by decreasing order of viscosity. In a modification of the process, the hydrophobic plasticizer or emulsifier may be added with the stage one ingredients.

Abstract: The disclosure relates to a sugarless center-filled gum wherein the sugarless chewing gum formulation can be extruded to form a hollow-centered rope and wherein the sugarless center-fill is not absorbed into the chewing gum. Both the chewing gum and the liquid fill have incorporated therein a composition comprising a natural or synthetic gum, glycerin humectant and an additional humectant which may be sorbitol solution or a combination of sorbitol solution and propylene glycol. Suitable synthetic or natural gums include carboxymethylcellulose, pectin, propylene glycol alginates, agar and gum tragacanth. The preferred composition which is incorporated into both the sugarless chewing gum formulation and the sugarless liquid fill contains sodium carboxymethylcellulose, glycerin and sorbitol solution.

Abstract: This invention relates to novel amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide having the Formula I: ##STR1## wherein R.sub.1 is hydrogen, halogen or lower alkyl; R.sub.2 is hydrogen, lower alkyl or aryl; Ar is aryl or heterocyclic; to the pharmaceutically acceptable salts thereof; and to processes for their preparation. The compounds of this invention exhibit antiinflammatory activity.

Abstract: A process for making aliphatic diperoxyacids comprising adding a dibasic acid having from 12 to 20 carbon atoms to a solution of from about 6% to about 14% hydrogen peroxide, about 69% to about 82% sulfuric acid and about 6% to about 21% water.

Abstract: Fabric conditioning articles comprising a receptacle releasably containing a pH control agent or electrolyte, and fabric conditioning particles which have a coating of an agent which is insolubilized/made indispersible by the pH control agent or electrolyte. The pH control agent or electrolyte in such articles being separated from the fabric conditioning particles. Methods of using the articles are also provided.