Abstract: The present invention relates to the therapeutic use of non-amine tropane analogues that bind to the SERT to treat neuropsychiatric disorders.

Abstract: New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.

Abstract: Disclosed are cutting blades for cutting tools and methods of making the blades. Such blades include tooth patterns with both set and non-set teeth. Each of the set teeth are set at an angle with respect to the jaw line of the blade, and each set tooth includes at least one surface feature that is effective to direct a portion of swarf that is produced via the cutting action of the blade into gullets of the blade such that less swarf overall is directed to the cutting surface of the objects being cut by the blade.

Abstract: According to a toner and a manufacturing method of the present invention, the toner, which is composed of a binding resin component precipitated in particle shapes with a coloring agent component dispersed in the binding resin component, is produced by dissolving the binding resin component in a supercritical fluid (a SCF), blending the coloring agent component in the SCF, and lowering solubility of the binding resin component for precipitating the binding resin component in the particle shapes. Even when the coloring agent content is increased, by the SCF, the toner can maintain dispersibility of the coloring agent component in the binding resin component precipitated in the particle shapes, meanwhile coloring power is also maintained thereby. Therefore, the toner can promote miniaturization of an image forming apparatus using the toner.

Abstract: The invention is directed to a method for directly producing a lost mold by machining a sand mold made with curable binders. The invention is intended in particular to decrease tool wear and to increase dimensional accuracy and exactness in the reproduction of the mold, in that a mold blank (1) to be machined is constructed by means of a pattern set (4) with the use of a variable or fixed molding box (2) and includes in its volume the desired contours of the casting mold and a machining allowance for the milling of the mold material. After filling of the molding box (2) with curable foundry mold materials, curing, and removal from the mold, the mold blank (1) is transformed into the casting mold by removal of the machining allowance by high-speed machining, milling or 3-D machining of freeform surfaces. The invention concerns lost molds for metal castings and the fabrication of casting prototypes and odd parts in the range of small-and medium-sized articles and production runs.

Abstract: An apparatus for producing a three-dimensional part by successive layer-by-layer solidification of a solidifiable material, which is solidified at locations corresponding to the cross section of the part is described. The apparatus has a machine housing and a building space provided in the machine housing. An interchangeable container forms a delimiting frame for the material within the building space. The container has a work piece platform. The work piece platform is supported on a supporting device during operation of the apparatus. Preferably, the interchangeable container has a rear side wall with a recess extending vertically, and the supporting device engages the work piece platform through the recess.

Abstract: The present invention provides novel phosphonic acid diester derivatives useful as medicines. The phosphonic acid diester derivatives are represented by the general formula: wherein R1 represents amino group, N-lower alkylamino group, N-lower alkenylamino group, or the like; R2 and R3 represent hydrogen atom, lower alkyl group, halogen atom, lower alkoxy group, or the like; R4 represents hydrogen atom, lower alkyl group or phenyl(lower)alkyl group; R5 and R6 represent lower alkyl group; X, Y and Z represent that all of them are carbon atoms or one of them is nitrogen atom and the other two are carbon atoms; Q represents a single bond or alkylene group; or the pharmacologically acceptable salts thereof.

Abstract: An oil strainer comprises upper and lower partial bodies, made of synthetic resin, joined together to form a roughly tube-shaped strainer main body, the interior of which is provided with a filter. The oil strainer has a flange section for attachment with bolts, and the flange section is provided with at least one bolt hole which passes through the interior of the roughly tube-shaped strainer main body. With this structure, it is possible to provide an oil strainer which can be installed on a small installation surface, which is able to reduce resin fatigue, and which can prevent impairment of the seal due to loosening of installation members.

Abstract: A leg prosthesis having an artificial knee joint with swing phase control and recoil break comprises a damping member acting upon the knee joint, detectors for detecting force, knee angle and acceleration and a control unit for controlling the dampening degree of the damping member on the basis of the detected values. The damping characteristics of the damping member are varied in dependence on control signals produced by the control unit on the basis of a viscosity change of the magneto-rheological liquid.

Abstract: A continuous process for the production of elemental aluminum is described. Aluminum is made from aluminum oxide and a reducing gas such as a light hydrocarbon gas or other reducing gas, for example hydrogen. In the process, a feed stream of the aluminum oxide and the reducing gas is continuously fed into a reaction zone. There the aluminum oxide and reducing gas are reacted at a temperature of about 1500° C. or greater in the reaction zone to provide a continuous product stream of reaction products, which include elemental aluminum. The product stream is continuously quenching after leaving the reaction zone, and the elemental aluminum is separated from the other reaction products.

Abstract: A retardation film made of a polymerized liquid crystal material of the present invention includes: a first region having a first flat surface pattern; and a second region having a second flat surface pattern, wherein a thickness in the first region is different from that in the second region, thereby retardations in the first region and in the second region are different from each other.

Abstract: There is provided a heating element and an arrangement of heating elements, respectively, for heating crucibles, in particular for LEC devices for growing semiconductor single crystals, with a tulip-shaped bottom heater (20) being built such that the heater legs of the main heater (40) positioned thereabove can barely be guided towards the bottom. Such arrangement of bottom and main heater enables multi-heater arrangements without having to interfere with a lateral insulation (18) which, thus, need not be cut out or pierced.

Abstract: The invention relates to a bainitically hardened brake disk comprising at least one ring-shaped cast disk (1) body with radially extending ring sections in contact with brake shoes (2). Said brake disk is mounted on the hub of a bicycle wheel (5) for braking purposes. In order to avoid noise emissions and vibrations, the inventive disk is made of cast iron, is highly tough and has a low weight. The aim is to avoid the disadvantages of combining disk brakes with an aluminium wheel hub. The inventive disk is characterized in that it has a thoroughly bainitically hardened body (1) made of cast iron with lamellar graphite (AGI), the brake disk is designed as a single piece and is linked to the wheel hub (5) through composite casting by forming a positive material fitting joint (15) in the area where the hub (5) is connected to the base (3) of the disk.

Abstract: An operating apparatus comprises an operating table with an operating support post, an operating table top and means for detachably fastening said operating table top to said operating support post, an anesthesis station and an examining station located at a distance from said operating support post and comprising an examining support post for receiving said operating table top. An overhead rail extends above said operating table and said examining station, and an overhead conveyor comprising means for carrying said operating table top is mounted on said overhead rail for movement therealong from a first position above said operating support post to a second position above said examining station. An overhead support carrying said anesthesis station is also mounted on said overhead rail for movement therealong. First coupling means are provided on said overhead conveyor and second coupling means are provided on said overhead support.

Abstract: A reflective type liquid crystal display device in accordance with the present invention includes a reflector film having excellent polarization preservation properties and an anisotropic diffusing film for diffusing only the light polarized in a particular direction. The anisotropic diffusing film is composed of a complex of liquid crystal and a polymer and selectively diffuses incident light. If a liquid crystal layer composed of dichroic dye and liquid crystal is employed, it becomes possible to carry out high contrast display with the anisotropic diffusing film and the reflector film and to prevent reflections of nearby objects appearing on the screen.

Abstract: A spacer for insertion between two vertebrae has a variable axial length. The spacer comprises a first sleeve-shaped shape member 1 and a second member 2 which is slidably guided within the first member in axial direction relative thereto for adjusting the overall length. The second member 2 comprises, on its outer portion facing the first member 1, an axially extending portion having ratchet notch means 18, and the first member 1 has an engagement member 23 cooperating with the ratchet notch means 18 for displacement to a desired overall length.

Abstract: A photoresist is applied to a first substrate made of glass or resin which has been subjected to alignment treatment. Next, the photoresist is exposed and developed by UV light so as to form a non-optical rotatory region in a stripe manner after a mask having a desired pattern is provided on the photoresist. Then, polymerized liquid crystal is applied or dropped on the substrate complex thus prepared so far after an alignment layer on the substrate is rubbed. Further, a second substrate whose surface has been subjected to alignment treatment is placed on the substrate complex such that the directions of the alignment of the two substrates are orthogonal to each other, and the substrate thus positioned is pressed against the substrate complex. Finally, the substrate complex is irradiated by the UV light to cure the polymerized liquid crystal so as to form an optical rotatory region, thereby completing an optical rotatory device.