Abstract: The subject invention concerns a method for therapeuticaly treating a patient afflicted with autoimmune disorders or disease. The subject method comprises admninistering to a patient an antibody composition that is capable of binding to and inhibiting self-reactive pathogenic anti-bodies present within the patient. Specifically exemplified is a method for treating systemic lupus erythematosis wherein the antibody composition administered to the patient comprises purified anti-DNA anti-idiotypic antibodies. The subject invention further concerns a method for purifying from pooled human gamma globulin preparations anti-idiotype antibodies useful in the present therapeutic method. The present invention further concerns a purified antibody composition useful in the present therapeutic method.

Abstract: The invention comprises a series of adenovirus-based vectors having deletions in the E1 and/or E3 regions, and also insertions of pBR322 sequences, which can be used to deliver nucleic acid inserts into host cells, tissues or organisms that then can express the insert. The invention includes the use of the vectors in introducing genes into cells, in making vaccines and in gene therapy.

Abstract: A method and device processes multi-channel audio signals, each channel corresponding to a loudspeaker placed in a particular location in a room, in such a way as to create, over headphones, the sensation of multiple "phantom" loudspeakers placed throughout the room. Head Related Transfer Functions (HRTFs) are chosen according to the elevation and azimuth of each intended loudspeaker relative to the listener, each channel being filtered with an HRTF such that when combined into left and right channels and played over headphones, the listener senses that the sound is actually produced by phantom loudspeakers placed throughout the "virtual" room. A database collection of sets of HRTF coefficients from numerous individuals and subsequent matching of the best HRTF set to the individual listener provides the listener with listening sensations similar to that which the listener, as an individual, would experience when listening to multiple loudspeakers placed throughout the room.