Patents Represented by Attorney Gerald P. Keleher

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  • Protein C derivatives
    Patent number: 6998122
    Abstract: Novel protein C derivatives are described. These polypeptides retain the biological activity of the wild-type human protein C with substantially longer half-lives in human blood. These polypeptides will require either less frequent administration and/or smaller dosage than wild-type human protein C in the treatment of vascular occlusive disorders, hypercoagulable states, thrombotic disorders and disease states predisposing to thrombosis.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: February 14, 2006
    Assignee: Eli Lilly and Company
    Inventors: Bruce Edward Gerlitz, Bryan Edward Jones, David Thompson Berg
  • Methods of optimizing antibody variable region binding affinity
    Patent number: 6849425
    Abstract: The invention provides a method of conferring donor CDR binding affinity onto an antibody acceptor variable region framework. The invention also provides a method of simultaneously grafting and optimizing the binding affinity of a variable region binding fragment. A method of optimizing the binding affinity of an antibody variable region is also provided.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: February 1, 2005
    Assignee: Ixsys, Inc.
    Inventors: William D. Huse, Jeffry D. Watkins, Herren Wu
  • Nucleic acids encoding a cysteine rich protein
    Patent number: 6503730
    Abstract: Nucleic acids encoding a new family of small cysteine rich soluble proteins, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: January 7, 2003
    Assignee: Schering Corporation
    Inventors: Karin Franz-Bacon, Daniel M. Gorman, Terrill K. McClanahan
  • Nucleic acids encoding mammalian cell membrane protein MDL-1
    Patent number: 6416973
    Abstract: The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells, e.g., lymphoid and myeloid, are provided, along with methods for their use.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: July 9, 2002
    Assignee: Schering Corporation
    Inventors: Alexander B. H. Bakker, Joseph H. Phillips, Lewis L. Lanier
  • Intracellular regulatory molecules; related reagents
    Patent number: 6274312
    Abstract: Purified genes encoding intracellular regulatory molecules from a human, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: December 10, 1997
    Date of Patent: August 14, 2001
    Assignee: Schering Corporation
    Inventors: Kurt C. Gish, Wolfgang Seghezzi, Frances Shanahan, Emma M. Lees, Terrill K. McClanahan
  • Ig superfamily `dlair` receptors expressed in monocytes
    Patent number: 6140076
    Abstract: DNA clones encoding a receptor in the Ig superfamily and a related soluble variant have been isolated from a human monocyte library. The invention provides receptor polypeptides, nucleic acids encoding them, expression vectors, and transformed cells for recombinant production of the polypeptides.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: October 31, 2000
    Assignee: Schering Corporation
    Inventors: Gosse Jan Adema, Linde Meyaard, Daniel M. Gorman, Terrill K. McClanahan, Lewis L. Lanier, Joseph H. Phillips, Jr.
  • Nucleic acids encoding mammalian proteinases; related reagents
    Patent number: 6140098
    Abstract: Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: October 31, 2000
    Assignee: Schering Corporation
    Inventors: Sriram Balasubramanian, John Ford, Daniel M. Gorman, Gerard Zurawski
  • Purified mammalian monocyte antigens and related reagents
    Patent number: 6124436
    Abstract: Cell surface antigens from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: February 13, 1996
    Date of Patent: September 26, 2000
    Assignee: Schering Corporation
    Inventors: Terrill K. McClanahan, Daniel M. Gorman, Laurel M. Bolin
  • Mammalian cell surface antigens; related reagents
    Patent number: 6111090
    Abstract: Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: August 14, 1997
    Date of Patent: August 29, 2000
    Assignee: Schering Corporation
    Inventors: Daniel M. Gorman, Troy D. Randall, Albert Zlotnik
  • Mammalian proteinases; oxidoreductases; related reagents
    Patent number: 6069229
    Abstract: Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: May 30, 2000
    Assignee: Schering Corporation
    Inventors: Lynette M. Dowling, Constance F. Huffine, Daniel M. Gorman
  • DNA encoding interleukin-B30
    Patent number: 6060284
    Abstract: Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using the reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: May 9, 2000
    Assignee: Schering Corporation
    Inventor: J. Fernando Bazan
  • Lymphotactin uses
    Patent number: 6022534
    Abstract: This invention relates to the use of lymphotactin or lymphotactin antagonists for administration to an animal. The administration of these therapeutic entities will attract certain cell types, or can be blocked to prevent such attraction. It also provides means to protect stem cells.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: February 8, 2000
    Assignee: Schering Corporation
    Inventors: Joseph A. Hedrick, Susan A. Hudak, Albert Zlotnik
  • DNA encoding IL-10-like homologue; related reagents
    Patent number: 5989867
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: November 23, 1999
    Inventors: Andrea Knappe, Helmut Fickenscher, Bernhard Fleckenstein
  • Mammalian cell surface antigens
    Patent number: 5977303
    Abstract: Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 2, 1999
    Assignee: Schering Corporation
    Inventors: Gregorio Aversa, Chia-Chun J. Chang, Benjamin G. Cocks, Jan E. de Vries
  • Cytokine-induced proliferation of amniotic t-cells
    Patent number: 5879937
    Abstract: The invention provides improved methods of prenatal diagnosis that can be performed earlier in pregnancy, and/or with greater safety, and/or rapidity, and/or with greater accuracy than conventional methods. A volume of amniotic fluid containing fetal cells is extracted from a pregnant woman, and the fetal T-cells are propagated in a culture medium comprising one or more cytokines. The fetal T-cells are then diagnosed for genetic defects.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: March 9, 1999
    Assignee: Schering Corporation
    Inventor: Maria-Grazia Roncarolo