Abstract: A smooth surfaced, inelastic, flexible, S-shaped or L-shaped belt-like strip for recording electrocardiograms having a series of separate precordial electrical contacts and laterally placed separate, independently movable precordial leads and electrodes movable laterally insuring proper placement on the patient's chest or precordium during usage. The S- and/or L-shape of the strip helps cover proper recording areas. Raised, fixed, compressible precordial electrodes maintain contact with each patient's chest allowing for variations in chest size among patients. The apparatus is attached to the chest with an adjustable elastic strap providing a constant and evenly distributed downward force holding it and the precordial leads in place. Lead wires exit the lateral sides of the precordial belt-like strip towards electrodes placed on each arm.
Abstract: An in-vehicle device for lifting objects into and out of the storage areas of the vehicle in which it is installed. The device is attached to the inside wall, floor, or ceiling area of the vehicle in which it is installed. It is fixedly attached to the vehicle by a mounting element which is connected to a swivel base element containing, in one embodiment, a winch with a cable running through a telescoping arm protruding from the base. The arm telescopes into and out of the base. The cable has a hook on its end to enable it to hook onto handles or ropes on objects to be stored in the vehicle and removed therefrom to a desired location. The winch is operated manually or by an electric motor or other mechanical means. The mounting element is attached to the vehicle by bolts, rivets, adhesives and the like. The base can be connected to the mounting element by a ball and socket joint to enable it to swivel in all directions, or it can be connected by a joint which enables it to swivel horizontally only.
Abstract: A smooth surfaced, inelastic, flexible, belt-like strip for recording electrocardiograms having a series of six separate precordial electrodes, three fixed and three being independently movable leads with electrodes and movable within a fixed range insuring proper placement on the patient's chest or precordium during usage, the S-shape of the belt-like strip enables it to cover the proper recording areas. The fixed, electrodes, which are raised and compressible, maintain contact with patients' chests despite variations in chest size among patients. The apparatus is attached around the chest with an adjustable elastic strap providing a constant and evenly distributed downward force holding it and the precordial contacts, which are between the strip and patient's chest, in place. Internal lead wires attach at the sides of the precordial belt-like strip with electrodes placed on each arm via external lead wires.
Abstract: A method of preventing, treating and/or controlling diseases caused by dysregulation and/or dysfunction of various portions of the nervous system which comprises administering to a patient, an effective amount of a compound of the avermectin family, e.g. ivermectin, in single or multiple doses of up to 1.6 mg/kg at intervals of from 3 days to 4 months.
Type:
Grant
Filed:
November 23, 1992
Date of Patent:
April 12, 1994
Assignee:
Fractal Laboratories, Inc.
Inventors:
Jonathan L. Costa, Jesus A. Diazgranados
Abstract: A method of treating comatose patients or near-comatose patients to increase their arousal and alertness as measured by the Glascow Coma Score by administering effective amounts of an adenosine receptor antagonist and a GABA agonist, either concomitantly in any order including simultaneously, or by administering an adenosine receptor antagonist as the sole active agent. The methods of administration are intravenous bolus or drip injection, subcutaneous injection or orally.
Type:
Grant
Filed:
June 30, 1992
Date of Patent:
September 28, 1993
Assignee:
Fractal Laboratories, Inc.
Inventors:
Jonathan L. Costa, Hernan V. Salazar, Jesus A. Diazgranados
Abstract: Certain aryl substituted naphthalene, benzoxepine, benzazepine and henzocycloheptene derivatives are disclosed. The compounds are useful in treating hyperproliferative skin disease, allergic reactions and inflammation.
Type:
Grant
Filed:
October 15, 1991
Date of Patent:
July 6, 1993
Assignee:
Schering Corporation
Inventors:
Neng-Yang Shih, Pietro Mangiaracina, Michael J. Green, Ashit K. Ganguly
Abstract: An apparatus for use with an exercise bicycle or a regular bicycle adapted for use as an exercise bicycle which comprises two elongated poles which are tapered at one end and optionally one of which is slidingly attached to a crossbar, said poles are inserted into eyebolts on the pedals of such bicycles. The eyebolts rotate axially independently of the axial rotation of the pedals to which they are attached and the pole or pipes can be moved in a circular arc in the eyebolts forward of and behind the vertical plane of the user's body.
Abstract: A compact, foldable, portable luggage carrier made of lightweight aluminum which when folded is light enough for easy hand carrying and storing. The apparatus is especially helpful for persons without sufficient strength to load luggage e.g., into an automobile trunk. The carrier is a rectangular platform on wheels with a handle structure containing a winch and pulley arrangement attached near one end of the platform. The handle structure comprises two upright posts attached at one end perpendicular to the platform and at the other end to the bottom ends of two additional posts supporting a winch, pulleys with a rope and hook for lifting the luggage and depositing it to a desired place, e.g. an automobile trunk and at the top end is a pulley arm parallel to the platform. The winch is manually or battery operated. The pulley arm's height from the platform is vertically adjusted by adjusting the top posts positions relative to the bottom posts.
Abstract: A method of preventing, treating and/or controlling diseases caused by dysregulation and/or dysfunction of various portions of the nervous system which comprises administering to a patient, an effective amount of a compound of the avermectin family, e.g. ivermectin, in single or multiple doses of up to 1.6 mg/kg at intervals of from 3 days to 4 months.
Type:
Grant
Filed:
June 7, 1991
Date of Patent:
February 23, 1993
Assignee:
Fractal Laboratories, Inc.
Inventors:
Jonathan L. Costa, Jesus A. Diazgranados
Abstract: Novel 2,2-disubstituted glycerol-like compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF"). Also disclosed are methods of synthesizing and using the compounds of the invention as well as pharmaceutical compositions thereof. The compounds have the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined in the specification.
Type:
Grant
Filed:
September 6, 1991
Date of Patent:
February 9, 1993
Assignee:
Schering Corporation
Inventors:
Daniel Solomon, James J. Kaminski, Steven K. White, Laura S. Lehman de Gaeta, Ashit K. Ganguly
Abstract: The novel triacetylenic dioxolone antifungal compound of this invention is isolated from the EV-22 complex of this invention which is elaborated by the microorganism Microbispora sp. SCC 1438, ATCC 53620.
Type:
Grant
Filed:
July 3, 1990
Date of Patent:
September 1, 1992
Assignee:
Schering Corporation
Inventors:
Mahesh Patel, Ann C. Horan, Joseph A. Marquez, J. Allan Waitz
Abstract: A compound represented by the formula I: ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen or (C.sub.2 -C.sub.10) alkanoyl in substantially chemically pure form, and pharmaceutical compositions thereof are disclosed.
Type:
Grant
Filed:
June 13, 1990
Date of Patent:
June 30, 1992
Assignee:
Schering Corporation
Inventors:
Raymond Cooper, Ann C. Horan, Joseph A. Marquez, Mahesh G. Patel
Abstract: The process for making certain bicyclic compounds and intermediates which are useful as anti-allergic, anti-inflammatory and cytoprotective agents.
Type:
Grant
Filed:
November 13, 1989
Date of Patent:
January 7, 1992
Assignee:
Schering Corporation
Inventors:
Dinesh Gala, Martin Steinman, Ashit Ganguly
Abstract: Active recombinant human IL-4 is purified from a crude fermentation broth of a secreted E. coli mutant by subjecting said solution to selective chromatogrphy on a zinc-chelating agarose column at pH 7.2 in a buffer containing a high concentration of sodium chloride, i.e., about 1M sodium chloride, washing first with a phosphate buffer at pH 7.2 containing 1.0M sodium chloride then with a buffer containing 10% glycerol and eluting at pH 5.0. The resulting purified active recombinant human IL-4 solution is further treated by cation exchange chromatography, concentration by diafiltration up to 20 mg/mL and size exclusion gel chromatography using a citrate buffer at pH 4.5.
Type:
Grant
Filed:
May 31, 1990
Date of Patent:
December 31, 1991
Assignee:
Schering Corporation
Inventors:
John C. T. Tang, David Naveh, Tattanahali L. Nagabhushan
Abstract: Novel 3-substituted-1-aryl-2(1H)-quinolones useful as anti-allery, anti-inflammatory, anti-hyperproliferative skin disease agents are disclosed. The quinolones are represented by Formula 1: Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.
Abstract: Non-aqueous waterproof oil-based topical compositions containing one or more water-in-oil emulsifiers having an HLB value of about 1 to about 7, e.g., sorbitan sesquioleate, and at least one cosmetic emollient, e.g., extra heavy mineral oil, as well as methods for making such compositions are disclosed. The waterproof compositions are particularly useful as vehicles for non-aqueous waterproof oil-based topical sunscreen compositions.
Type:
Grant
Filed:
September 29, 1986
Date of Patent:
September 10, 1991
Assignee:
Schering-Plough Healthcare Products, Inc.