Abstract: The bone grinder of this invention is capable of consistently producing ground bone particles of varying particle sizes, depending on the grinder head employed. The device provides the ability to easily interchange grinder heads according to the needs of a surgeon and the novel grinder head design optimizes the use of available bone stock by cutting the bone rather than crushing the bone.

Abstract: This invention provides a method for making adenovirus cloning vectors which contain a recombinase target site that is useful for the insertion of selected foreign proteins.

Abstract: This method for non-invasively, rapidly and simply distinguishing between allergies, viral infections and sinusitis involves testing nasal secretions, preferably with commercially available (Ames Division, Miles Laboratories, Inc., Elkhart, Ind. 46515; or from Boehringer Mannheim Corporation, Advanced Diagnostics, 9115 Hague Road, P.O. Box 50457, Indianapolis, Ind. 46250-0457) or novel, modified reagent test strips. The commercially available strips, also referred to as dipsticks, test for pH, protein, nitrite, glucose, ketone, white blood cell esterase, bilirubin and blood. In the method of this invention, a sample of a patient's nasal secretions is tested and, based on the pH, amount of protein, nitrite, esterase and a measure of eosinophil infiltration, it can quickly be determined if the patient is suffering from an allergy, from a viral infection or a bacterial infection. The method has the potential to supplant much more expensive and invasive clinical procedures.

Abstract: DNA fragments from Porphyromonas gingivalis which express proteins that elicit anti-P. gingivalis immunologic responses are described. Microorganisms, genetically modified to express P. gingivalis antigens, are provided. Also disclosed are probes, vaccines, and monoclonal antibodies for the detection and prevention of periodontal disease.

Abstract: DNA fragments from Porphyromonas gingivalis which express proteins that elicit anti-P. gingivalis immunologic responses are described. Microorganisms, genetically modified to express P. gingivalis antigens, are provided. Also disclosed are probes, vaccines, and monoclonal antibodies for the detection and prevention of periodontal disease.

Abstract: A dowel is provided by obtaining a plug from the shaft (diaphysis) of various long bones. The dowel has an intra-medullary canal which can be packed with any of a variety of osteogenic materials. The dowel has a cortical surface into which an instrument attachment hole may be machined and onto which an alignment mark may be inscribed for proper orientation of the intra-medullary canal. The dowel has a chamfered insertion end and has improved biomechanical and vertebral fusion induction properties as compared to standard dowels known in the art.