Patents Represented by Attorney Gezina Holtrust
  • Patent number: 5164402
    Abstract: Quinolone carboxylic acids 7-substituted by azabicyclo groups have antibacterial activity.
    Type: Grant
    Filed: February 4, 1991
    Date of Patent: November 17, 1992
    Assignee: Pfizer Inc
    Inventor: Katherine E. Brighty
  • Patent number: 5147873
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, or a pharmaceutically acceptable cation;Y is cyclopropyl, ethyl or p-fluorophenyl, and X is hydrogen or fluoro, or X and Y taken together form a group ##STR2## wherein R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl; or a pharmaceutically acceptable salt thereof. Also disclosed are antibacterial pharmaceutical compositions comprising the foregoing compounds, methods of using the compounds in treating bacterial infections, and intermediates for the preparation of the compounds.
    Type: Grant
    Filed: February 15, 1991
    Date of Patent: September 15, 1992
    Assignee: Pfizer Inc.
    Inventor: Edward F. Kleinman
  • Patent number: 5138060
    Abstract: Azabicyclo[2.2.2]octan-3-imines of the general formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein are prepared by reacting a compound of the formula ##STR2## with a compound of the formula ##STR3## wherein A is MgCl, MgBr or Li.
    Type: Grant
    Filed: January 3, 1991
    Date of Patent: August 11, 1992
    Assignee: Pfizer Inc.
    Inventors: Dennis M. Godek, Charles W. Murtiashaw
  • Patent number: 5091383
    Abstract: Antibacterial compounds have the formula ##STR1## wherein R.sup.1 is hydrogen, a pharmaceutically acceptable cation, or alkyl; A is CH, CF, CCl or N; Y is alkyl, haloalkyl, cyclopropyl, vinyl, methoxy, N-methylamino, p-fluorophenyl, p-hydroxyphenyl or p-aminophenyl; or A is carbon and is taken together with Y and the carbon and nitrogen to which A and Y are attached to form a five to seven membered ring which is optionally substituted; and R.sup.2 is a bridged-diazabicycloalkyl group.
    Type: Grant
    Filed: February 16, 1988
    Date of Patent: February 25, 1992
    Assignee: Pfizer Inc.
    Inventors: Martin R. Jefson, Paul R. McGuirk
  • Patent number: 5075442
    Abstract: Oxophthalazinyl acetic acids having benzothiazole side chains are prepared by reacting an oxophthalazinyl thioacetamide acetate with hydrogen sulfide and a nitrophenyl compound having a reactive group such that the benzothiazole side chain may be formed by ring closure involving the thiocaetamide group. The oxophthalazinyl thioacetamide may be prepared by reacting the corresponding cyanomethyloxophthalazinyl acetate with hydrogen sulfide in the presence of tertiary amines. Analogous indazole and oxopyridopyridazinone acetic acids may be prepared similarly, as well as oxophthalazinyl, indazole and oxopyridopyridazinone acetic acids having thiazolopyridinyl side chains.
    Type: Grant
    Filed: June 15, 1990
    Date of Patent: December 24, 1991
    Assignee: Pfizer Inc.
    Inventors: Banavara L. Mylari, William J. Zembrowski
  • Patent number: 5064958
    Abstract: Quinolonecarboxylic acid intermediates useful in the preparation of antibacterial 6-fluoro-7-substituted-quinolonecarboxylic aids are prepared from 2-(iodo, bromo or chloro)-3-fluoro-4-(fluoro or chloro)-phenyl carboxylic acid or ester.
    Type: Grant
    Filed: February 12, 1990
    Date of Patent: November 12, 1991
    Assignee: Pfizer Inc.
    Inventor: Brian T. O'Neill
  • Patent number: 5064830
    Abstract: Certain derivatives of oxophthalazinyl acetic acids of the formula ##STR1## wherein R.sub.1 is hydroxy or a prodrug group, and R.sub.2 and R.sub.3 are independently hydrogen, fluoro, chloro or trifluoromethyl, except that R.sub.2 and R.sub.3 are not both hydrogen, or a pharmaceutically acceptable base addition salt of a compound of formula I wherein R.sub.1 is hydroxy, are capable of lowering blood uric acid levels in mammals. These oxophthalazinyl acetic acid derivatives are for instance useful for treating gout and gouty arthritis in a mammal .
    Type: Grant
    Filed: August 2, 1990
    Date of Patent: November 12, 1991
    Assignee: Pfizer Inc.
    Inventor: Paden C. Going
  • Patent number: 5048510
    Abstract: An implantable penile prosthesis comprises a tubular body for implantation in a patient's penis and a fluid reservoir for implantation in a patient's body outside the penis. The tubular body and reservoir are in fluid communication with each other. The tubular body comprises a tubular chamber which is inflatable from a flaccid to an erect state when filled substantially to capacity. Fluid flow to and from the chamber is by way of a manually actuatable valve system. The valve system moves between an open position allowing for change from the erect state to the flaccid state, and a closed position allowing for change from the flaccid state to the erect state.
    Type: Grant
    Filed: August 29, 1988
    Date of Patent: September 17, 1991
    Assignee: American Medical Systems, Inc.
    Inventors: Sidney F. Hauschild, John C. Hill, Dezso K. Levius
  • Patent number: 5036153
    Abstract: (R,R)-2,5-Diazabicyclo[ 2.2.1]heptanes are prepared from a compound of the formula ##STR1## wherein X and R.sub.2 are as defined herein, by heating with tosylchloride in pyridine, reacting the formed compound of the formula ##STR2## with a C.sub.1 -C.sub.6 alkylamine or ammonia, and reducing or hydrolyzing the formed compound of the formula ##STR3## wherein R.sub.1 is hydrogen or C.sub.1 -C.sub.6 alkyl.
    Type: Grant
    Filed: October 18, 1989
    Date of Patent: July 30, 1991
    Inventors: Tamim F. Braish, Darrell E. Fox
  • Patent number: 5000776
    Abstract: Plants and trees are effectively treated with erythorbic acid or salts thereof to reduce ozone damage to their crops.
    Type: Grant
    Filed: March 24, 1988
    Date of Patent: March 19, 1991
    Assignee: Pfizer Inc.
    Inventor: Vincent J. Carroll
  • Patent number: 4969892
    Abstract: An anchoring means for anchoring a suture in tissue comprises a housing, a substantially cylindrical means within said housing for receiving a suture, and an adjusting means. Another anchoring means comprises a housing, a rotating spool within said housing, a driving gear, and an adjusting means.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: November 13, 1990
    Assignee: AMS, Inc.
    Inventors: John H. Burton, Reginald C. Bruskewitz, A. Michael Mikulich, William D. Saville
  • Patent number: 4954629
    Abstract: Oxophthalazinyl acetic acids having benzothiazole side chains are prepared by reacting an oxophthalazinyl thioacetamide acetate with hydrogen sulfide and a nitrophenyl compound having a reactive group such that the benzothiazole side chain may be formed by ring closure involving the thioacetamide group. The oxophthalazinyl thioacetamide may be prepared by reacting the corresponding cyanomethyloxophthalazinyl acetate with hydrogen sulfide in the presence of tertiary amines. Analogous indazole and oxopyridopyridazinone acetic acids may be prepared similarly, as well as oxophthalazinyl, indazole and oxopyridopyridazinone acetic acids having thiazolopyridinyl side chains.
    Type: Grant
    Filed: May 11, 1989
    Date of Patent: September 4, 1990
    Assignee: Pfizer Inc.
    Inventors: Banavara L. Mylari, William J. Zembrowski
  • Patent number: 4939140
    Abstract: A heterocyclic oxophthalazinyl acetic acid having aldose reductast inhibitory activity of the formula ##STR1## wherein X is oxygen or sulfur; Z is a covalent bond, O, S, NH or CH.sub.2 or CHR.sub.5 Z is vinyl; R.sub.1 is hydroxy, or a prodrug group; R.sub.2 is a heterocyclic group, R.sub.3 and R.sub.4 are hydrogen or the same or a different substituent, and R.sub.5 is hydrogen, methyl or trifluoromethyl. The pharmaceutically acceptable acid addition salts of the above compounds wherein R.sub.1 is di(C.sub.1 -C.sub.4)alkylamino or (C.sub.1 -C.sub.4)alkoxy substituted by N-morpholino or di(C.sub.1 -C.sub.4)alkylamino and the pharmaceutically active base addition salts of the above compounds wherein R.sub.1 is hydroxy are also aldose reductase inhibitors.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: July 3, 1990
    Assignee: Pfizer Inc.
    Inventors: Eric R. Larson, Banavara L. Mylari
  • Patent number: 4938760
    Abstract: A method for suspending the urethrovesical junction in females comprises inserting sutures through a puncture or incision in the suprapubic abdominal area or through a puncture or incision in the vaginal wall, suspending the urethrovesical junction with the sutures, and anchoring the sutures with an anchoring means at an anchoring site. The anchoring means is a relatively rigid helix having an attaching means to attach the suture, or a pad adapted to be delivered with a delivery means to the anchoring site, or a flip anchor in substantial axial alignment with a placement means and adapted to be flipped from the axial alignment to an angled position, or an adjustable tissue anchor having a means for adjustably attaching the sutures.
    Type: Grant
    Filed: March 29, 1989
    Date of Patent: July 3, 1990
    Assignee: American Medical Systems, Inc.
    Inventors: John H. Burton, Reginald C. Bruskewitz, Michael A. Mikulich, William D. Saville
  • Patent number: 4939290
    Abstract: Quinolonecarboxylic acid intermediaes useful in the preparation of antibacterial 6-fluouro-7-substituted-quinolonecarboxylic acids are prepared from 2-(iodo, bromo or chloro)-3-fluoro-4-(fluoro or chloro)-phenyl carboxylic acid or ester.
    Type: Grant
    Filed: November 23, 1988
    Date of Patent: July 3, 1990
    Assignee: Pfizer Inc.
    Inventor: Brian T. O'Neill
  • Patent number: 4909785
    Abstract: A method and apparatus for valving body fluids involving a flexible tubular body with a drainage canal therethrough, including collapsible means for blocking the passageway and thereby preventing the flow of urine. The length of the device is such that one end protrudes into the bladder and the other end terminates interior of the meatus. The device includes a means for anchoring to secure it in place and a plug device for deflating and releasing the anchoring means and for collapsing the blocking means to facilitate removal of the device from the body. The device is manually actuable to an open position and means are provided to delay the closing of the device for a sufficient period of time to allow voiding of the bladder. The collapsible and expandable nature of the device facilitates its insertion and removal, particularly while passing through areas of restricted diameter.
    Type: Grant
    Filed: November 2, 1988
    Date of Patent: March 20, 1990
    Assignee: American Medical Systems, Inc.
    Inventors: John H. Burton, Eric P. Berg, Bradford G. Staehle, Frank B. Scott
  • Patent number: 4900844
    Abstract: A process for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains comprising reacting an oxophthalizinyl acetic acid ester with an aniline derivative is disclosed. Also disclosed are processes for the preparation of such oxopthalizinyl esters.
    Type: Grant
    Filed: May 19, 1989
    Date of Patent: February 13, 1990
    Assignee: Pfizer Inc.
    Inventors: Banavara L. Mylari, William J. Zembrowski
  • Patent number: 4895943
    Abstract: Processes and intermediates for preparing 1,4-diazabicyclo[3.2.2.]nonane including a process for the preparation of a compound of the formula ##STR1## wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkyl substituted with 1 to 6 halo groups; and R.sup.2 is hydrogen, naphthoyl, substituted naphthoyl, benzyl, substituted benzyl, benzoyl or substituted benzoyl, wherein each of said substituted naphthoyl, substituted benzyl, and substituted benzoyl is substituted with one to three substituents selected from the group consisting of halo, C.sub.1 -C.sub.4 alkoxy and C.sub.1 -C.sub.4 alkyl, comprising reacting a compound of the formula ##STR2## wherein R.sup.1 and R.sup.3 are independently selected from C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkyl substituted with 1 to 6 halo groups with an alkyl stannane or a trialkyl aluminum and, if desired, reacting the resulting compound of the formula III wherein R.sup.
    Type: Grant
    Filed: October 25, 1988
    Date of Patent: January 23, 1990
    Assignee: Pfizer Inc.
    Inventors: Robert C. Friedmann, John W. Lackey, Brian T. O'Neill
  • Patent number: 4895724
    Abstract: Compositions for the controlled and prolonged release of macromolecular compounds comprise a porous matrix of chitosan having dispersed therein the macromolecular compound. Examples of macromolecules used in the composition are pharmacologically active ones such as peptide hormones, e.g. growth hormone.
    Type: Grant
    Filed: June 7, 1985
    Date of Patent: January 23, 1990
    Assignee: Pfizer Inc.
    Inventors: John R. Cardinal, William J. Curatolo, Charles D. Ebert
  • Patent number: 4895139
    Abstract: An implantable penile prosthesis comprises a tubular body for implantation in a patient's penis and a fluid reservoir for implantation in a patient's body outside the penis. The tubular body and reservoir are in fluid communication with each other. The tubular body comprises a tubular chamber which is inflatable from a flaccid to an erect state when filled substantially to capacity. Fluid flow to and from the chamber is by way of a manually actuatable valve system. The valve system moves between an open position allowing for change from the erect state to the flaccid state, and a closed position allowing for change from the flaccid state to the erect state. The valve system is movable from the second closed position to the first open position by bending of the penis.
    Type: Grant
    Filed: August 29, 1988
    Date of Patent: January 23, 1990
    Assignee: American Medical Systems, Inc.
    Inventors: Sidney F. Hauschild, Dezso K. Levius