Abstract: The present invention provides pharmaceutically active compounds formula I
wherein R1 is —H, —OH, —O(C1-C4 alkyl), —OCOC6H5, —OCO(C1-C6 alkyl), or —OSO2(C2-C6 alkyl);
R2 is —H, —OH, —O(C1-C4 alkyl), —OCOC6H5, —OCO(C1-C6 alkyl), —OSO2(C2-C6 alkyl), or halo;
R3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; and
n is 2 or 3; and
or a pharmaceutically acceptable salt thereof.
Also provided are compounds of formula II
wherein
R1a is —H or —OR5 in which R5 is a hydroxy protecting group.
R2a is —H, halo, or —OR6 in which R6 is a hydroxy protecting group; and
R4 is —OH or —CHO; or a pharmaceutically acceptable salt thereof.