Abstract: A non-deforming deflectable multi-lumen catheter with an outer jacket having a deflectable distal end portion, an eccentric pull wire lumen, coil and shim embedded therein. The deflectable distal portion optionally having one or more transaxial notches in the external surface of the outer jacket. A functional device is disposed within the lumen of an inner tube substantially coaxial with the outer jacket of the catheter. The distal tip of the functional device egressible from the distal tip of the catheter, and upon deflection, automatically aligns with the distal tip of the catheter and functional device.

Abstract: A steerable percutaneous catheter for guiding at least one functional device to selected surfaces of a body for treatment thereon, particularly adapted for laser-assisted Percutaneous Transmyocardial Revascularization (PTMR). The steerable catheter has a handle portion at its proximal end and a controllably deflectable end portion at its distal end. The distal end of the catheter and the distal end of the functional device maintain alignment automatically during deflection. The invention also includes a surface contact detection system to detect contact with an interior body surface, such as the heart wall.

Abstract: An improved flow control device for regulating the flow of liquid or gas through a length of flexible-conduit using a generally enclosed rack and pinion assembly engaged by an external slidable assembly or switch. The case has a lower rack with a surface supporting a length of flexible conduit, opposing walls, and an upper surface. The lower rack has at least one rack track along which a pinion gear assembly may be engaged and rotated. The pinion gear assembly has a cylinder shaft capped on at least one end by a pinion gear with radiating teeth. The pinion gear assembly can be rotated along a portion of the flexible conduit, compressing it at one or more positions. Operation of the flow control device can be accomplished using a single hand, and the case remains enclosed without subjecting the pinion gear assembly to an external environment.

Abstract: An elongated steerable catheter for placement within a heart chamber, organ aperture or other body opening and having at least one center tube with hollow passageway for guiding a laser delivery means or other functional device to selected surfaces of a heart chamber, organ aperture or other body cavity for laser or other treatment thereon, particularly adapted for laser-assisted percutaneous transmyocardial revascularization (TMR), is disclosed herein. The steerable catheter has a handle portion at its proximal end and a controllably deflectable end portion at its distal end. The elongated center tube has a distal end, in the region where a curvature is to be formed, and a shim anchor sleeve is slidably disposed over the center tube. The shim anchor sleeve is attached to the inside wall of the outer jacket and coupled to the distal end of the center tube with a bendable shim member which extends between the distal tip of the steerable catheter and the sleeve over the center tube.

Abstract: A method for orally administering vitamin preparations is described which combine vitamin B12 (B12, cobalamin) and folic acid (folate), with and without pyridoxine (B6), for preventing and treating elevated serum homocysteine (HC), cystathionine (CT), methylmalonic acid (MMA), or 2-methylcitric acid (2-MCA) levels. These metabolites have been shown to be indicative of B12 and/or folic acid deficiencies. Further, it is likely that a B6 deficiency may be present with a B12 or folate deficiency. The method of the invention is also for use in lowering serum HC, CT, MMA, or 2-MCA in patients with or at risk for neuropsychiatric, vascular, renal or hematologic diseases. The method of the present invention eliminates the costly and time consuming steps of distinguishing between vitamin deficiencies once a deficiency is found by measurement of serum metabolite levels.

Abstract: A system for treating a patient's heart which comprises a means to form channels in the heart wall and a means to deliver a therapeutic or diagnostic agent into the channels. Additionally, the system may comprise a means to retain the agent within the channels for a useful period of time. The system may be configured to be introduced percutaneously or intraoperatively. The system generally comprises an elongated, flexible lasing transmission means having a laser radiation emitting means and an delivery lumen opening at the distal end. Practice of the invention comprises forming channels in the heart wall and delivering a therapeutic or diagnostic agent into the channel. Gene therapy agents of this invention comprise vectors for transferring genetic information to the heart tissue in vivo or harvested cells which have been genetically engineered in vitro. Additionally, the invention may comprise retaining the agent within the channels, for example, by incorporating the agent in a viscous carrier.

Abstract: A germicidal method and apparatus for destroying airborne pathogenic bacteria such as tuberculosis bacteria using ultraviolet light. Air is drawn through a filter and into a sterilization chamber that is irradiated with ultraviolet light, and out through an exhaust opening. Consideration for the characteristics of the room in which the apparatus is installed and the positioning of the installation allows effective prevention of transmission of disease through expectoration and inhalation of airborne microdroplets of bacteria-containing sputum. The filter is of the low-density type which traps large particulates, but not small particulates of the size of the microdroplets, so that the filter does not become a bacteria colonization site. Baffles on the air intake opening and air exhaust opening to prevent ultraviolet light from escaping into the environment.

Abstract: An apparatus and method for creating drug-filled pockets within muscle tissue, such as myocardium of the heart for increasing angiogenesis. More particularly, the apparatus has an excising assembly with a dilator tip for penetrating and advancing through the surface and body of a muscle or organ, such as the heart. Preferably, the dilator tip has a low level laser optical fiber emission to ease the passage of the excising assembly and provide thermal damage which also stimulates angiogenesis. More preferably, the dilator tip also disperses a pharmacologically active substance as the apparatus is passed through the tissue and/or creates pockets. The excising assembly is connected to a hand-held control device from which the operator pushes a switch to activate a punching mechanism within the excising assembly. The punching mechanism cuts a discrete piece of muscle tissue and traps it within the excising assembly leaving a pocket in the remaining muscle tissue.

Abstract: A method and apparatus for determining oxygenation and hemoglobin parameters in tissue measures light scattering parameters of light directed through the tissue, using an array of VCSELs, for light directed at more than one frequency. This allows for the calculation of Hb, HbO2, and other parameters.

Abstract: A method for detecting and preventing unauthorized or illegal attempts to gain enhanced privileges within a computing environment by exploiting the buffer overflow-related weakness of the computer system.

Abstract: A method of selecting laser parameters for performing laser-assisted myocardial revascularization to avoid inducing undesired cardiac arrhythmia without synchronization of delivery of laser energy and the patient's cardiac cycle, the method comprising the steps of minimizing the power level of laser energy used, thereby decreasing the overall trauma to the heart, selecting a pulse frequency as great as possible while avoiding adverse summation effects, selecting a pulse width as wide as possible to prevent excessively high peak powers per pulse and not so wide as to cause undesired thermal damage, selecting an energy flux rate, shaping the front end of each pulse of laser energy to provide efficient, non-explosive TMR channeling, and correcting the selected power level, pulse width, pulse frequency and energy flux rate for mechanical events, including method of access to the heart, position of selected portions of myocardium in the heart, temporal duration of the procedure, natural movement of the heart,

Abstract: A system for notifying passengers waiting for public transit vehicles of the status of the vehicles, including the arrival times of vehicles at stops. The system includes global position determining devices located in the vehicles for determining the location of the vehicles along their routes. A central processor or computer is coupled to the global position determining devices for receiving the locations of vehicles therefrom. The processor is programmed to compute and update from the present location of the transit system vehicles and electronically stored information a transit data table which includes status information for all the vehicles in the system, including the location of scheduled stops, connections to other transit vehicles at the stops, and the arrival times of vehicles at their stops.

Abstract: An addressable process control relay comprises a solid-state relay with an embedded network client. Such client is basically hardware compatible with the physical layer interfaces of a general class of serial networks, and has a variety of down-loadable or embedded protocol personalities that can respond to a particular proprietary network. Such protocol personalities are preferred to include: Fieldbus, process field bus (PROFIBUS), Seriplex, smart distributed system (SDS), DeviceNet, controller area network (CAN), etc.

Abstract: A process for identifying a single item from a family of items presents a user with a feature screen having a series of groupings. Each grouping represents a feature having a set of alternatives from which to select. Selected alternatives are used as a selection criteria in a search operation. Results of the search operation is a revised feature screen indicating alternatives that remain available to the user for further selection and searching. The feature screen and search process, therefore, presents the user with a guided nonhierarchical parametric search to identify matching items based upon user specified criteria and priorities. Also disclosed is an adaptation of the claimed method and system appropriate in an Internet environment.

Abstract: A knee prosthesis which more accurately reproduces the rollback of natural knee movement and, thus, reduces wear on the tibial component. The knee prosthesis includes a femoral component with two cams, the first located between the posterior condylar sections and the second located towards the anterior end of the condylar sections with a slot surface therebetween. The tibial component includes a spine which engages each cam as it rotates along the femoral component and the slot surface during flexion and extension.

Abstract: A treasure hunt type game that utilizes global positioning satellite (“GPS”) equipped wireless communications devices. Players are given clues or directions to proceed along one of many predetermined treasure hunt routes based on their location as determined by the GPS. Based on these clues or directions, players change their locations. Based on these changed locations, as determined by the GPS, additional clues or directions are given to the players until one of the players completes the treasure hunt route and arrives at the treasure to win the game. The game also incorporates other variables in determining the clues to provide to players, such as the location of other players as determined by their GPS devices, the previous locations of the player and other players and whether the player has correctly solved certain clues.

Abstract: An apparatus for performing transmyocardial revascularization provides a closed-chest formation of a channel in a wall of a heart. An articulating scope in one embodiment includes a flexible distal portion which provides for a coupling of a surface of the heart to the distal portion. The articulating distal portion is coupled to a control member to provide articulation. Movement of the control member causes deflection, including articulation, of the generally flexible working end of the scope. The coupler may be a two way valve to provide both vacuum and flushing solutions. The articulating scope can be supported by a scope holder that is table mounted or mounted to the patient. An access port provides for the introduction of tools and instruments. An adaptor couples the access port with a handle. The handle provides a working channel for the introduction of an energy delivery device.

Abstract: A dual-temperature refrigerating device for partially freezing beverage inside a sealed beverage container. One compartment within the device is held at a temperature below freezing and another compartment is kept at a temperature above freezing. An opening between the two compartments allows a beverage container to be placed so that is simultaneously exposed to below-freezing temperatures above-freezing temperatures. This arrangement causes the beverage in the portion of the container exposed to the below-freezing temperatures to freeze while the beverage in the part of the container exposed to above freezing temperatures does not freeze.

Abstract: A method for orally administering vitamin preparations is described which combine vitamin B12 (B12, cobalamin) and folic acid (folate), with and without pyridoxine (B6), for preventing and treating elevated serum homocysteine (HC), cystathionine (CT), methylmalonic acid (MMA), or 2-methylcitric acid (2-MCA) levels. These metabolites have been shown to be indicative of B12 and/or folic acid deficiencies. Further, it is likely that a B6 deficiency may be present with a B12 or folate deficiency. The method of the invention is also for use in lowering serum HC, CT, MMA, or 2-MCA in patients with or at risk for neuropsychiatric, vascular, renal or hematologic diseases. One embodiment of the invention is the use of a non-prescription formulation containing 2.0 mg B12 and 0.4 mg folic acid, with and without 25 mg B6. Another embodiment uses a prescription strength formulation containing 2.0 mg B12 and 1.0 mg folic acid, with and without 25 mg B6.

Abstract: A beverage container having a beverage compartment and an ice compartment. Prior to beverage consumption, the container is placed in a dual-temperature environment that freezes the beverage in the ice compartment but doesn't freeze the beverage in the beverage compartment. A barrier inside the beverage container minimize the mixing of the beverage in one compartment with the beverage in the other compartment, allowing the beverage in the ice compartment to freeze while the beverage in the beverage compartment does not. Once removed from refrigeration, the frozen beverage in the ice compartment keeps the beverage in the beverage compartment cool for an extended period of time.