Patents Represented by Law Firm Gilberto M. Villacorta, Pepper Hamilton LLP
  • Compounds containing a michael-acceptor, especially maleimide or maleic acid derivatives, directly or indirectly linked to a chromophore and their use in long lasting sunscreen compositions
    Patent number: 5877204
    Abstract: The present invention relates to compounds which are useful as sunscreens. The compounds persist on the skin for much longer than conventional sunscreens because they comprise a Michael acceptor linked directly or indirectly to a chromophore. The Michael acceptor is capable of undergoing a conjugate addition reaction with thiol groups present in cysteine residues of keratin and thus the compound is chemically bound to the skin and will not be removed by immersion in water.
    Type: Grant
    Filed: November 5, 1996
    Date of Patent: March 2, 1999
    Assignee: Vanguard Medica Limited
    Inventors: Bruce Everett Davison, Bryan Colin Nicholas Morgan Jones, Charon Robin Ganellin, Paul Beaumont Bishop, David Jack
  • Reduction of infarct volume using citicoline
    Patent number: 5872108
    Abstract: The invention is directed to a method of reducing the extent of infarction, particularly cerebral infarction subsequent to cerebral ischemia, by the administration of citicoline shortly after an ischemic episode and continuing daily treatment for up to about 30 days, preferably for at least about 6 weeks. The method is useful in the treatment of stroke and severe head trauma patients and maximizes the chances for a full or substantially full recovery of the patient.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: February 16, 1999
    Assignee: Interneuron Pharmaceuticals, Inc.
    Inventors: Bobby W. Sandage, Jr., Marc Fisher, Kenneth W. Locke
  • Process for the manufacture of 3-amino-substituted glycosylated bile acids
    Patent number: 5864022
    Abstract: The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Intermediates and related compounds are also disclosed. In particular, the present invention permits the conversion of cholic acid esters to the 3-amino-7,12-bis(glucosyl)cholic acid esters via an azide intermediate. Conditions for the purification and isolation of the desired product is also disclosed to provide an overall manufacturing process suitable for large-scale production.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: January 26, 1999
    Assignee: Intercardia, Inc.
    Inventors: Anna K. Chen, Ramesh Kakarla, Dashan Liu, Michael J. Sofia, Thomas C. Zebovitz