Abstract: The invention relates to methods that permit the rapid construction of oligosaccharides and other glycoconjugates. Methods for forming multiple glycosidic linkages in solution in a single step are disclosed. The invention takes advantage of the discovery that the relative reactivity of glycoside residues containing anomeric sulfoxides and nucleophilic functional groups can be controlled. In another aspect of the invention, the reactivity of activated anomeric sugar sulfoxides is utilized in a solid phase method for the formation of glycosidic linkages. The methods disclosed may be applied to the preparation of specific oligosaccharides and other glycoconjugates, as well as to the preparation of glycosidic libraries comprising mixtures of various oligosaccharides, including glycoconjugates, which can be screened for biological activity.

Abstract: The rear axle suspension system is retrofittably attachable to spaced-apart suspension mountings of an ambulance type of vehicle. The suspension system has an axle bearing arm having a first end that pivotally connects with one of the suspension mountings, and an opposite second end. A complementary arm has a first end that pivotally connects with the other one of the suspension mountings, and an opposite second end pivotally connected to the second end of the axle bearing arm. An axle bracket is secured to the axle bearing arm at or near the second end thereof, to receive the rear axle. A pair of spaced-apart absorber bearing arms downwardly project respectively from the axle bearing and complementary arms and face each other. A shock absorber is mounted between the absorber bearing arms.