Patents Represented by Attorney Ginger R. Dreger

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  • Insulin-like growth factor agonist molecules
    Patent number: 6716586
    Abstract: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: April 6, 2004
    Assignee: Genentech, Inc.
    Inventors: Ross G. Clark, Henry B. Lowman, Iain C. A. F. Robinson
  • Insulin-like growth factor agonist molecules
    Patent number: 6713451
    Abstract: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: March 30, 2004
    Assignee: Genentech, Inc.
    Inventors: Ross G. Clark, Henry B. Lowman, Iain C. A. F. Robinson
  • AL-2 neurotrophic factor nucleic acid
    Patent number: 6696557
    Abstract: The present invention provides nucleic acids encoding AL-2 protein, host cells and vectors containing these nucleic acids, and methods for their use to produce AL-2 protein by recombinant DNA methods.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: February 24, 2004
    Assignee: Genentech, Inc.
    Inventor: Ingrid W. Caras
  • Insulin-like growth factor agonist molecules
    Patent number: 6693078
    Abstract: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: February 17, 2004
    Assignee: Genentech, Inc.
    Inventors: Ross G. Clark, Henry B. Lowman, Iain C. A. F. Robinson
  • Insulin-like growth factor agonist molecules
    Patent number: 6693079
    Abstract: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: February 17, 2004
    Assignee: Genentech, Inc.
    Inventors: Ross G. Clark, Henry B. Lowman, Iain C. A. F. Robinson
  • Recombinant baculoviruses producing insect toxins
    Patent number: 6689356
    Abstract: A recombinant baculovirus is provided with a genetic coding sequence for the production of a foreign protein that is toxic to insects. Preferred are nuclear polyhedrosis viruses, with preferred embodiments having been constructed and expressed in insect cells: BmNPV.AaIT and AcNPV.AaIT. Both embodiments function in insect cells infected therewith so as to have the toxin AaIT (originating from the venom of the scorpion A. australis) secreted. A clone designated (pCIB4223), which contains the Bombyx mori signal sequence fused to the AaIT sequence, has been deposited with the American type culture collection and designated “ATCC 40906.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 10, 2004
    Assignees: The Regents of the Unviersity of California, BASF Aktiengesellschaft
    Inventors: Eliahu Zlotkin, Susumu Maeda, Billy Fred McCutchen, Bruce D. Hammock, Elizabeth Fowler, Rama M. Belagaje
  • Insulin-like growth factor agonist molecules
    Patent number: 6689751
    Abstract: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: February 10, 2004
    Assignee: Genentech, Inc.
    Inventors: Ross G. Clark, Henry B. Lowman, Iain C. A. F. Robinson
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 6686451
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: February 3, 2004
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Jennie P. Mather, P. Mickey Williams, William I. Wood
  • Insulin-like growth factor agonist molecules
    Patent number: 6683053
    Abstract: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: January 27, 2004
    Assignee: Genentech, Inc.
    Inventors: Ross G. Clark, Henry B. Lowman, Iain C. A. F. Robinson
  • Controlled release microencapsulated NGF formulation
    Patent number: 6663899
    Abstract: NGF microencapsulation compositions having controlled release characteristics, preferably with increased stability, for the NGF component, particularly human recombinant NGF (“rhNGF”) are provided that yield enhanced stability of NGF for use in promoting nerve cell growth, repair, survival, differentiation, maturation or function. Methods for making and using such compositions are also provided.
    Type: Grant
    Filed: June 11, 1998
    Date of Patent: December 16, 2003
    Assignee: Genentech, Inc.
    Inventors: Jeffrey L. Cleland, Xanthe M. Lam, Eileen T. Duenas
  • Treatment of inner ear hair cells
    Patent number: 6653279
    Abstract: Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: November 25, 2003
    Assignee: Genentech, Inc.
    Inventor: Wei-Qiang Gao
  • Decay accelerating factor (DAF) and nucleic acid encoding it
    Patent number: 6632634
    Abstract: Novel fusions of a GPI signal domain and a polypeptide heterologous to the GPI signal domain donor polypeptide are provided for industrial use. Therapeutic administration of the GPI-linked product of the fusions enables the targeting of biological activity to cell membrane surfaces.
    Type: Grant
    Filed: January 27, 1998
    Date of Patent: October 14, 2003
    Assignee: Genentech, Inc.
    Inventors: Ingrid W. Caras, Michael A. Davitz, Victor Nussenzweig, David W. Martin, Jr.
  • Rodent HER2 tumor model
    Patent number: 6632979
    Abstract: The invention concerns HER2-transgenic non-human mammals, animal models for screening drug candidates for the treatment of diseases and disorders associated with the overexpression of HER2. In particular, the invention concerns animal models designed to test drug candidates for the treatment of HER2-overexpressing cancers, including breast cancer, that are not responding or poorly responding to current treatments.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: October 14, 2003
    Assignee: Genentech, Inc.
    Inventors: Sharon Erickson, Kathleen King, Ralph Schwall
  • Insulin-like growth factor agonist molecules
    Patent number: 6632794
    Abstract: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: October 14, 2003
    Assignee: Genentech, Inc.
    Inventors: Ross G. Clark, Henry B. Lowman, Iain C. A. F. Robinson
  • Methods of enhancing cognitive function using an AL-1 neurotrophic factor immunoadhesin
    Patent number: 6610296
    Abstract: The present invention provides methods of enhancing cognitive function in mammals by administering intracerebrally a homo-multimeric immunoadhesin molecule that contains the extracellular domain of AL-1, also known as ephrin-A5.
    Type: Grant
    Filed: January 2, 1996
    Date of Patent: August 26, 2003
    Assignee: Genentech, Inc.
    Inventors: Ingrid W. Caras, John W. Winslow
  • Process for making ice pops
    Patent number: 6610336
    Abstract: A process for making confection compositions such as ice pops of gel consistency, in the absence of heat treatment which takes advantage of a chemical reaction between an alginate salt, other than calcium alginate, or a low methoxy pectin and free calcium provides a homogeneous gel product which can be subsequently depositing into a mold pocket and converted into a desired product such as an ice pop by traditional steps.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: August 26, 2003
    Assignee: Ice Cream Partners USA, LLC
    Inventor: Mike Poorman
  • Fluorescent protein sensors for measuring the pH of a biological sample
    Patent number: 6608189
    Abstract: Disclosed are fluorescent protein sensors for measuring the pH of a sample, nucleic acids encoding them, and methods of use. The preferred fluorescent protein sensors are variants of the green fluorescent protein (GFP) from Aequorea victoria. Also disclosed are compositions and methods for measuring the pH of a specific region of a cell, such as the mitochondrial matrix or the Golgi lumen.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: August 19, 2003
    Assignee: University of California
    Inventors: Roger Y. Tsien, Juan Llopis, Rebekka M. Wachter, S. James Remington
  • Insulin-like growth factor agonist molecules
    Patent number: 6608031
    Abstract: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: August 19, 2003
    Assignee: Genentech, Inc.
    Inventors: Ross G. Clark, Henry B. Lowman, Iain C. A. F. Robinson
  • Insect control method with genetically engineered biopesticides
    Patent number: 6596271
    Abstract: Insect pests can be controlled by treating the pests or their loci with a combination of recombinant virus and organic insecticide. The recombinant virus preferably is a baculovirus. Combinations of recombinant baculovirus with chemical insecticides provide a dose-response in pests, such as insects, that is greater than additive. Preferred treatments of the invention are uses of recombinant baculoviruses that express a foreign protein or toxin, with pyrethroid insecticides. Treatments against pyrethroid resistant pests are especially useful.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: July 22, 2003
    Assignee: The Regents of the University of California
    Inventors: Bruce D. Hammock, Billy Fred McCutchen
  • Tie ligand homologues
    Patent number: 6586397
    Abstract: The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL1, NL5 and NL8, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: July 1, 2003
    Assignee: Genentech, Inc.
    Inventors: Paul J. Godowski, Austin L. Gurney