Patents Represented by Attorney, Agent or Law Firm Giulio A. DeConti, Jr., P
  • Methods for identifying G protein coupled receptor effectors
    Patent number: 6255059
    Abstract: The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screening of large numbers of polypeptides in a yeast expression library to identifying those polypeptides which induce or antagonize receptor bioactivity. The subject assay is particularly amenable for identifying surrogate ligands for orphan receptors.
    Type: Grant
    Filed: January 17, 1996
    Date of Patent: July 3, 2001
    Assignee: Cadus Pharmaceutical Corporation
    Inventors: Christine A. Klein, Andrew J. M. Murphy, Dana M. Fowlkes, James Broach, John Manfredi, Jeremy Paul, Joshua Trueheart