Patents Represented by Attorney, Agent or Law Firm Giulio A. DiConti
  • Patent number: 6472507
    Abstract: The present invention relates to a novel drug delivery system of use in the improved delivery of drug therapeutic agents into target cells. The system comprises a drug moiety linked to a carrier moiety wherein the carrier moiety comprises a homeobox peptide or a fragment or derivative thereof.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: October 29, 2002
    Assignee: Cyclacel Limited
    Inventors: Peter M. Fischer, Shudong Wang, Nikolai Zhelev
  • Patent number: 6455499
    Abstract: Methods of treating a subject having a disorder associated with LHRH activity are disclosed.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: September 24, 2002
    Assignee: Indiana University Foundation
    Inventor: Roger W. Roeske
  • Patent number: 5912121
    Abstract: The invention pertains to methods for detecting the presence or absence of a mutation associated with hypertrophic cardiomyopathy (HC). The methods include providing DNA which encodes a sarcomeric thin filament protein (e.g., .alpha.-tropomyosin or cardiac troponin T) and detecting the presence or absence of a mutation in the amplified product which is associated with HC. DNA encoding an actin-associated protein, a myosin-associated protein, or a sarcomeric protein other than .beta. cardiac heavy chain can also be used in the methods of the present invention. The invention further pertains to methods for diagnosing familial HC (FHC) in a subject. These methods typically include obtaining a sample of DNA which encodes a sarcomeric thin filament protein from a subject being tested for FHC and diagnosing the subject for FHC by detecting the presence or absence of a mutation in the sarcomeric thin filament protein which causes FHC as an indication of the disease.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: June 15, 1999
    Assignees: Bringham and Women's Hospital, President and Fellows of Harvard College
    Inventors: Christine Seidman, Jonathan Seidman, Ludwig Thierfelder, Hugh Watkins, Calum McRae