Abstract: The present invention relates to a novel drug delivery system of use in the improved delivery of drug therapeutic agents into target cells. The system comprises a drug moiety linked to a carrier moiety wherein the carrier moiety comprises a homeobox peptide or a fragment or derivative thereof.
Type:
Grant
Filed:
July 2, 1999
Date of Patent:
October 29, 2002
Assignee:
Cyclacel Limited
Inventors:
Peter M. Fischer, Shudong Wang, Nikolai Zhelev
Abstract: The invention pertains to methods for detecting the presence or absence of a mutation associated with hypertrophic cardiomyopathy (HC). The methods include providing DNA which encodes a sarcomeric thin filament protein (e.g., .alpha.-tropomyosin or cardiac troponin T) and detecting the presence or absence of a mutation in the amplified product which is associated with HC. DNA encoding an actin-associated protein, a myosin-associated protein, or a sarcomeric protein other than .beta. cardiac heavy chain can also be used in the methods of the present invention. The invention further pertains to methods for diagnosing familial HC (FHC) in a subject. These methods typically include obtaining a sample of DNA which encodes a sarcomeric thin filament protein from a subject being tested for FHC and diagnosing the subject for FHC by detecting the presence or absence of a mutation in the sarcomeric thin filament protein which causes FHC as an indication of the disease.
Type:
Grant
Filed:
December 12, 1994
Date of Patent:
June 15, 1999
Assignees:
Bringham and Women's Hospital, President and Fellows of Harvard College
Inventors:
Christine Seidman, Jonathan Seidman, Ludwig Thierfelder, Hugh Watkins, Calum McRae