Patents Represented by Attorney GlaxoSmithKline - Global Patents

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  • Live attenuated rotavirus vaccine for oral administration
    Patent number: 8192747
    Abstract: This invention provides liquid rotavirus formulations that are suitable for oral administration to human infants. In particular, the invention provides pharmaceutical compositions and vaccines, comprising a rotavirus antigen, a sugar and a carboxylate, wherein said formulation has a pH of between pH 5.0 and pH 8.0 and comprises no phosphate or less than 5 mM phosphate. The invention also provides methods of preparing said rotavirus formulations and use thereof in the prevention or treatment or rotavirus associated diseases in humans.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: June 5, 2012
    Assignee: GlaxoSmithKline Biologicals, s.a.
    Inventor: Vincent Vande Velde
  • Mixture of human papillomavirus virus-like particles
    Patent number: 7815915
    Abstract: The present invention relates to a vaccine composition comprising VLPs containing L1 proteins or functional L1 protein derivatives from HPV 16, HPV 18, HPV 31 and HPV 45 genotypes.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: October 19, 2010
    Assignee: GlaxoSmithKline Biologicals, s.a.
    Inventor: Martine Anne Cecile Wettendorff
  • Immunogenic composition of a homogeneous live attenuated human rotavirus population
    Patent number: 7790180
    Abstract: The invention provides an attenuated rotavirus population comprising a single variant or substantially a single variant which is defined by a nucleotide sequence encoding at least one of the major viral proteins designated as VP4 and VP7. The invention particularly provides a rotavirus population designated as P43. The invention further provides a novel formulation for a rotavirus vaccine which is in the form of a quick dissolving tablet for immediate dissolution when placed on the tongue.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: September 7, 2010
    Assignee: Glaxosmithkline Biologicals SA
    Inventors: Brigitte Desiree Alberte Colau, Francoise Denamur, Isabelle Knott, Annick Poliszczak, Georges Thiry, Vincent Vande Velde
  • Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52
    Patent number: 7758866
    Abstract: An immunogenic composition and methods for producing said composition, the composition comprising VLPs from HPV 16 and 18 and at least one other HPV cancer type, the other cancer type being selected from the list consisting of HPV types 31, 45 and 52, wherein the dose of the VLP of the at least one other cancer types is reduced relative to that of HPV 16 or 18.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: July 20, 2010
    Assignee: GlaxoSmithKline Biologicals, S.A.
    Inventors: Serge Debrus, Marie-Therese Martin, Robert John Stephen, Jean Stephenne, Martine Anne Cecile Wettendorff