Patents Represented by Attorney Glen J. Gesicki

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  • Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
    Patent number: 8299243
    Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: October 30, 2012
    Assignee: AbbVie Inc.
    Inventors: Yujia Dai, Steven K. Davidsen, Anna M. Ericsson, Kresna Hartandi, Zhiqin Ji, Michael R. Michaelides
  • Crystalline chemotherapeutic
    Patent number: 7960564
    Abstract: N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N?-(2-fluoro-5-methylphenyl)urea Crystalline Form 1, ways to make it, formulations comprising it and made with it and methods of treating patients having disease using it are disclosed.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: June 14, 2011
    Assignee: Abbott Laboratories
    Inventors: Thomas B. Borchardt, Michael J. Rozema
  • Kinase inhibitors
    Patent number: 7812166
    Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: October 12, 2010
    Assignee: Abbott Laboratories
    Inventors: Yujia Dai, Kresna Hartandi, Michael R. Michaelides
  • Substituted pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors
    Patent number: 7772231
    Abstract: Compounds of formula (25) that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: August 10, 2010
    Assignee: Abbott Laboratories
    Inventors: George S. Sheppard, Gary T. Wang, Fabio Palazzo, Randy L Bell, Robert A. Mantei, Jieyi Wang, Robert D. Hubbard, Megumi Kawai, Scott A. Erickson, Nwe BaMaung, Steve D. Fidanze
  • Crystalline form 2 of the chemotherapeutic N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N?-(2-fluoro-5-methylphenyl)urea
    Patent number: 7772404
    Abstract: N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N?-(2-fluoro-5-methylphenyl)urea Crystalline Form 2, ways to make it, formulations comprising it and made with it and methods of treating patients having disease using it are disclosed.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: August 10, 2010
    Assignee: Abbott Laboratories
    Inventors: Thomas B. Borchardt, Alexander F. Chu-Kung
  • Crystalline N-(4-(4-ammoniumthieno[2,3-d]pyrimidin-5-yl)phenyl)-N?-(2-fluoro-5-(trifluoromethyl)phenyl)urea benzenesulfonate
    Patent number: 7745622
    Abstract: A crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N?-(2-fluoro-5-(trifluoromethyl)phenyl)urea benzenesulfonate characterized in the triclinic crystal system and P-1 space group, when measured with radiation at 0.7107 ?, by lattice parameters a, b and c of 7.800 ?±0.001 ?, 13.406 ?±0.002 ? and 13.554 ?±0.002 ?, respectively and ?, ? and ? of 67.155±0.002, 79.724°±0.002° and 84.067±0.002, respectively, ways to make it, compositions comprising it, and methods of treatment using it are disclosed.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: June 29, 2010
    Assignee: Abbott Laboratories, Inc.
    Inventors: Sean M. Mellican, Cathie L. Linton, Jianzhang Mei, Jason S. Tedrow, Nahathai Charukamnoetkanok, Rodger Henry
  • Crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N?-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate
    Patent number: 7745448
    Abstract: A crystalline N-(4-(4-aminothieno[2,3 -d]pyrimidin-5-yl)phenyl)-N?-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate characterized in the monoclinic crystal system and P21/n space group, when measured with radiation at 0.7107 ?, by lattice parameters a, b and c of 5.0318 ?±0.006 ?, 23.684 ?±0.002 ? and 18.877 ?±0.002 ?, respectively, and ? of 90.703±0.003, ways to make it, compositions comprising it, and methods of treatment using it are disclosed.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: June 29, 2010
    Assignee: Abbott Laboratories Inc.
    Inventors: Sean M. Mellican, Cathie L. Linton, Jianzhang Mei, Jason S. Tedrow, Nahathai Charukamnoetkanok, Rodger Henry
  • Crystalline form of a drug
    Patent number: 7727953
    Abstract: Ac-Sar-Gly-Val-D-allo-Ile-Thr-Nva-Ile-Arg-ProNHCH2CH3 Crystalline Form 1, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: June 1, 2010
    Assignee: Abbott Laboratories Inc.
    Inventors: John C. Tolle, Ahmad Y. Sheikh