Abstract: This invention relates to saw blades for use in reciprocating hand-manipulated saws. The blades of the invention have a straight, untoothed edge lying parallel to the longitudinal axis of the blade and a toothed edge wherein at least 30% of the toothed edge is curved.

Abstract: Acetylated low density lipoproteins are combined with active and effective lipophilic peptide or other lipophilic immunomodulators, antigens or vaccines to carry the same to macrophage specific targeted receptor mediated endocytosis sites in a living system for treatment of cancer, infection hyperimmune related diseases or deficiences, or to enhance vaccine induction of immunity. Such receptor mediated endocytosis sites are found on macrophages, monocytes and endothelial cells in organs and tissues of the body.The combination of acetyl-LDL and a lipophilic peptide or related lipophilic immunomodulators, antigens, polynucleotides or vaccines enables delivery of such to be made across vascular barriers by transcytosis. The penetration of endothelial blood-brain, eye or testicular barriers is included in this concept.

Abstract: The steroid hormone dehydroepiandrosterone (DHEA), when administered by feeding or by subcutaneous injection, significantly improves the host response to viral infection. Experimental animal data shows that, with infection (100,000 plaque forming units/animal) of a human coxsackievirus B4 strain, which causes mortality in about 90% of infected animals, mortality was reduced to 37% when animals were treated with DHEA. Moreover, DHEA induced an 80% elevation in the number of antibody forming cells, particularly in cells forming gamma globulin M (early antibodies), and gamma globulin G (secondary antibodies). This elevation in the number of antibody forming cells was evident only in DHEA treated and virus infected animals, but not in uninfected animals treated with DHEA or in infected animals not treated with DHEA. In virus infected and DHEA treated animals there was also an elevation in the number of monocyte cells, the particular white blood cell associated with a resistance to this infection.

Abstract: The invention provides a method for preparation of probes for use in detecting enteroinvasive Escherichia coli and Shigella species. The small probes provide reliable and inexpensive means for detecting the pathogens in food samples and in environmental and clinical samples.

Abstract: Automatic orientation of predefined chemical structures in conjunction with a computer terminal employs respective protocols corresponding to a system state. The system states can include a chain state, ring state, library state, and retrieve state. Upon orientation, the object is attached according to a specified attachment command to a parent graph. The protocols corresponding to connection of the object to the parent includes rules regarding angles at which the structures can be attached to one another, and another protocol governs rules respecting rotation of the stored object through predetermined angles. Nodes of the object recalled are automatically provided with markers in alphabetic order from the most recently used marker corresponding to a letter of alphabet. Multiple alphabet sequences are used. Specification of position is indicated by inputting the lower case letter of the alphabet corresponding to the location desired. Bonds can be specified between two markers.

Abstract: Compounds which are active against retroviruses have the following formulaHOH.sub.2 C--CH.dbd.C.dbd.CH--Bwherein B is a purine or pyrimidine heterocyclic ring which is preferably selected from the group consisting of cytosine, 5-halo substituted cytosine, 5-alkyl substituted cytosine, 6-aminopurine, 2,6-diaminopurine, 6-hydroxypurine, 2-amino-6-hydroxypurine, 3-deazapurines, 7-deazapurines, 8-azapurines, and 6-azapyrimidines.

Abstract: Hybridomas producing antibodies having specific binding affinity against Pneumocystis carinii having been obtained and a method and kit for detecting P. carinii infection in humans having been described.

Abstract: A method of determining and imaging the temperature or temperature change of a liquid or solid object by NMR placing the object in a magnetic field B.sub.o at a temperature T.sub.o.sup.i, subjecting the object or a limited volume thereof to a first series of NMR imaging sequences to obtain first numerical values or images of molecular diffusion coefficients D.sub.o for individual points of the object or the limited volume thereof and recording the first series of images, maintaining the object or limited volume thereof at a temperature T.sup.i or waiting for a spontaneous change to the temperature, subjecting the object to a second series of magnetic resonance imaging sequences to obtain second numerical values or images of molecular diffusion coefficients D.sup.i for the same points of the object or the limited volume thereof and recording the second series of images, comparing point-by point the values or images of the diffusion coefficients D.sub.o.sup.

Abstract: A device for delivering high intensity light to a patient's eyes for treating seasonal affective disorder and the like uses a point source of light such as a high intensity halogen or other incandescent bulb, and directs a large fraction of the light from the bulb directly into the patient's eyes without focusing the light in such a way as to cause damage to the eye or discomfort to the patient. This is accomplished by the use of a positive lens which focuses the light from the high intensity bulb directly in front of the patient's eyes. The light appears to the patient to be coming from an area much larger than the actual point source, and hence is more comfortable for the patient. The patient is assured of receiving a significant dosage of light no matter which way he is directing his gaze.