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  • Production of recombinant selenoprotein mutants with enhanced catalytic activity
    Patent number: 8236936
    Abstract: The present invention generally relates to the production of industrially relevant quantities of selenoprotein enzymes in eukaryotic cell cultures. More specifically, the present invention generally relates to the production of such enzymes wherein one or more catalytic cysteine or serine residues are mutagenically replaced by selenocysteine.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: August 7, 2012
    Assignee: Ohio State University
    Inventors: Richard Sayre, Hangsik Moon