Abstract: New N-substituted N'-heterobicyclic piperazines corresponding to the general formula I: ##STR1## wherein: R represents: ##STR2## D represents a single bond, except when R represents naphthyl, or a hydrocarbon chain having 1 to 8 carbon atoms inclusive which is straight-chain or branched by a gem-dimethyl; andA-B represents: --(CH.sub.2).sub.2 --O--, --(CH.sub.2).sub.3 --O--, or --CO--CH.dbd.CH--,as well as their possible stereoisomers, epimers, and pharmaceutically-acceptable acid addition salts thereof; and medicinal products containing the same, useful in the treatment of a disorder requiring a 5-HT.sub.1A receptor antagonist.
Type:
Grant
Filed:
June 11, 1993
Date of Patent:
November 7, 1995
Assignee:
Adir et Compagnie
Inventors:
Jean-Louis Peglion, Bertrand Goument, Mark Millan, Jean-Michel Rivet
Abstract: A method, for the conveyance of molten metal from one place to another, in a high-temperature molten metal pool in a metal-melting furnace or out of said molten metal pool, employing an at least partially-inclined elongated conveying conduit and gas feed means for feeding inert gas into the lower end of the conveying conduit and thereby inducing a flow of molten metal in and through said conveying conduit, is disclosed, along with suitable apparatus for carrying out the said method wherein the parts or elements coming into contact with the high-temperature molten metal pool are of a suitable refractory material. According to the present invention, the inert gas is fed into the conveying conduit at a supersonic velocity, thereby simultaneously effecting a degassing of the molten metal while it is being conveyed.
Abstract: The present invention relates to indane derivatives with the following formula: ##STR1## wherein R.sub.1 is H, Halogen, an alkyl group having from one to three carbon atoms inclusive, methoxy, a methylthio-group, or a trifluoromethyl group,n is 2-4X is O or S,Y is O, CH.sub.2 or N--R.sub.2, where R.sub.2 is hydrogen or an (1-6 C) alkyl, (2-6 C) alkenyl or cycloalkyl-methyl group having from three to six carbon atoms,Z is --(CH.sub.2).sub.n --, n is 2 or 3 or Z is 1,2-phenylene optionally substituted with halogen or trifluoromethyl or Z=1,2--C.sub.6 H.sub.4 CO-- (to form a quinazolidinone or -thione ring system). U=N or C.Each compound exists as geometric isomers and each of these as a pair of optical isomers; and the separation and isolation of these are also within the scope of the invention.Moreover, pharmaceutically acceptable acid addition salts of the compounds of Formula I are within the scope of the present invention.
Abstract: A tie for connecting together parts of a structure, for example a stay for suspending the deck of a bridge from a tower, is constructed so that its length can be adjusted in a simple manner with the tie in service. The tie is made up from several stressed steel tendons, enclosed in a protective sheath filled with hardened material. At its ends the sheath incorporates anchoring devices for the transfer of the pull from the tie to the structure. The sheath forms a conduit whose ends are fixed securely to the anchoring devices. The conduit is isolated, throughout its length, from the structure so as to be capable of sliding longitudinally with respect thereto. At least one of the anchoring devices includes connection means for the active part of a tensioning apparatus and also includes means for bearing against the structure. This bearing means is adjustable on the anchoring device in the longitudinal direction of the tie.
Type:
Grant
Filed:
July 2, 1975
Date of Patent:
July 6, 1976
Assignee:
Societe Technique pour l'Utilisation de la Precontrainte