Patents Represented by Attorney Gordon W. Hueschen
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Patent number: 5998461Abstract: This invention relates to benzofuran/pyran derivatives of a new tricyclic amide compound, their composition and method of use for treating disorders of the melatoninergic system.Type: GrantFiled: July 28, 1998Date of Patent: December 7, 1999Assignee: Adir Et CompagnieInventors: Daniel Lesieur, Patrick Depreux, Ve'ronique Leclerc, Hamid Ait Mansour, Philippe Delagrange, Pierre Renard
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Patent number: 5925665Abstract: Compound of formula (I): in which R is as defined in the description, as well as their isomers and their pharmaceutically acceptable acid additions salts. Medicinal products containing the same are useful as Imidazoline receptors ligand.Type: GrantFiled: December 3, 1997Date of Patent: July 20, 1999Assignee: Adir Et CompagnieInventors: Marc Payard, Saadia Danoun, Genevieve Baziard-Mouysset, Maria Anastassiadou, Daniel-Henri Caignard, Pierre Renard, Dominique Manechez, Elizabeth Scalbert, Marie-Claire Rettori
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Patent number: 5849781Abstract: The invention relates to a compound selected from these of formula (I): ##STR1## in which R.sub.7, R.sub.8, Y, n and A are as defined in the description, and medicinal product containing the same useful for treating a disorder of the melatoninergic system.Type: GrantFiled: October 1, 1997Date of Patent: December 15, 1998Assignee: Adir Et CompagnieInventors: Michel Langlois, Monique Mathe-Allainmat, Philippe Delagrange, Pierre Renard, Beatrice Guardiola
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Patent number: 5731352Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which A, R.sub.1, R'.sub.1, R.sub.2, R.sub.3 and n are as defined in the description, and medicinal product containing the same useful for treating a mammal afflicted with a disorder of the melatoninergic system.Type: GrantFiled: May 30, 1996Date of Patent: March 24, 1998Assignee: Adir Et CompagnieInventors: Daniel Lesieur, Veronique Leclerc, Patrick Depreux, Philippe Delagrange, Pierre Renard
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Patent number: 5726177Abstract: Novel indole-derived azylpiperazines of general formula (I), wherein, inter alia, R.sub.1 is NH.sub.2 or NO.sub.2, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3 and R.sub.4 are H, Z is --C-- and X is 0. Methods for preparing such derivatives and the therapeutical uses thereof are also disclosed.Type: GrantFiled: May 17, 1996Date of Patent: March 10, 1998Assignee: Pierre Fabre MedicamentInventors: Serge Halazy, Michel Perez, Michael Briley, Peter Pauwels
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Patent number: 5726208Abstract: New compounds of formula: ##STR1## wherein: --A--D--E, X, n, Y and Z are as defined in the description, in racemic form and in the form of optical isomers,and their addition salts with pharmaceutically acceptable acids.Those compounds may be used as medicaments.Type: GrantFiled: October 11, 1996Date of Patent: March 10, 1998Assignee: Adir et CompagnieInventors: Jean-Louis Peglion, Bertrand Goument, Jean-Christophe Harmange, Joel Vian, Aimee Dessinges, Mark Millan, Valerie Audinot
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Patent number: 5564777Abstract: A foldable chair entirely in the form of a single piece of plastic, comprising a seat, a back hingedly connected to the seat, arm rests hingedly connected to the side edges of the seat, a rear leg assembly hingedly connected to the rear edge of the seat, and a front leg assembly hingedly connected to the front edge of the seat. The entire structure including the hinges is integral and comprised of the same piece of plastic material. The chair is erected by folding the front and rear leg assemblies in place, folding the arm rests over the seat, thereby retaining the leg assemblies in place, and affixing the arm rests to the back of the chair, thereby resulting in a strong rigid chair.Type: GrantFiled: June 7, 1995Date of Patent: October 15, 1996Inventor: Franklin J. Wild
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Patent number: 5565580Abstract: The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof whereinone R.sup.21 and R.sup.22 is alkyl and the other is hydrogen or both of R.sup.21 and R.sup.22 are hydrogen;and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.11, R.sup.12, R.sup.13, and R.sup.14 each independently are hydrogen, halogen, CF.sub.3, CN, or NO.sub.2 ; provided that at least one of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.11, R.sup.12, R.sup.13, and R.sup.14 are different from hydrogenThe compounds are useful as in vivo active glutamate antagonists.Type: GrantFiled: January 13, 1995Date of Patent: October 15, 1996Assignee: NeuroSearch A/SInventor: Frank W atjen
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Patent number: 5536719Abstract: A compound of formula (I): ##STR1## in the form of its S enantiomer, its addition salts with a pharmaceutically acceptable acid or base and medicinal product containing the same are useful for the treatment or prevention of pathologies associated with dysfunction of glutamatergic neurotransmission.Type: GrantFiled: July 11, 1995Date of Patent: July 16, 1996Assignee: Adir et CompagnieInventors: Alex Cordi, Michael Spedding, Bernard Serkiz, Jean Lepagnol, Patrice Desos, Philippe Morain
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Patent number: 5534511Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, X and n are as defined in the description, the optical isomers thereof, and the addition salts thereof with a pharmaceutically acceptable acid or base and medicinal product containing the same, useful for treating a mammal afflicted with a pathology associated with the sigma receptors.Type: GrantFiled: March 21, 1995Date of Patent: July 9, 1996Assignee: Adir et CompagnieInventors: Ange Mouithys-Mickalad, Patrick Depreux, Daniel Lesieur, Gerard Adam, Daniel-Henri Caignard, Pierre Renard, Marie-Claire Rettori
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Patent number: 5525597Abstract: Insecticidal compositions, comprising normally-employed insecticides but comprising also an effective activity-enhancing amount of capsaicin or other capsaicinoid, especially in the form of capsicum, exhibit synergistic effects against numerous insects, including especially bud worms, boll worms, cabbage loopers, army worms, beet army worms, and beetles, and are especially effective on cotton, soybeans, common garden vegetables, and flowers, when sprayed on the insect or its habitat, especially as an aqueous solution, suspension, or emulsion. Larger crop stands may be effectively treated by aerial spraying from the usual crop-dusting airplane.Type: GrantFiled: December 14, 1993Date of Patent: June 11, 1996Assignee: Kalamazoo Holdings, Inc.Inventors: Gary C. Hainrihar, James G. Dubberly, John T. Greenlee
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Patent number: 5512595Abstract: New substituted phenoxyisobutyric acids and esters that can be used as medicaments and correspond to the formula: ##STR1## wherein X, A, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and Z are as defined in the description.Those compounds and their physiologically tolerable salts can be used therapeutically.Type: GrantFiled: April 19, 1994Date of Patent: April 30, 1996Assignee: Adir et CompagnieInventors: Gilbert Regnier, Claude Guillonneau, Jean-Paul Vilaine, Albert Lenaers, Christine Breugnot
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Patent number: 5512569Abstract: The invention relates to the compounds of formula (I): ##STR1## in which R.sub.1 and R.sup.2 are as defined in the description, the optical isomers thereof,and an addition salt thereof with a pharmaceutically-acceptable acid or base, and medicinal product useful for treating a mammal afflicted with a disease associated with sigma receptors.Type: GrantFiled: March 21, 1995Date of Patent: April 30, 1996Assignee: Adir et CompagnieInventors: Hamid A. Mansour, Thierry Taverne, Raymond Houssin, Isabelle Lesieur, Patrick Depreux, Geard Adam, Daniel-Henri Caignard, Pierre Renard, Marie-Claire Rettori
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Patent number: 5510408Abstract: A composition of methacrilic resin which constitutes a resin possessing an outstandingly easy release from the mold of injection molding machine without defilement of the stamper and the peripheral ring of stamper holder, and therefore proves suitable material for replica of raser disk is provided. This methacrylic resin composition is characterized by having incorporated in a methyl methacrylate copolymer the three lubricant components, i.e. a higher alcohol (x), a monoglyceride of a higher fatty acid (y), and a paraffin (z), in such amounts that the individual contents of (x), (y), and (z) are in the respective ranges of 0.05 to 0.2% by weight, 0.05 to 0.2% by weight, and 0.02 to 0.15% by weight and the total content of (x), (y), and (z) is in the range of 0.2 to 0.35% by weight.Type: GrantFiled: May 26, 1994Date of Patent: April 23, 1996Assignee: Kuraray Co., Ltd.Inventors: Yoshio Fuchigami, Kouichi Warino, Shigeo Matsumaru, Yosokichi Kobayashi
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Patent number: 5510374Abstract: The invention relates to compounds of the formula (I): ##STR1## in which: Z represents oxygen,R.sub.1 represents alkyl,R.sub.2 represents hydrogen or alkyl,n represents 1 through 6,R.sub.3 represents unsubstituted or substituted phenylacylamino, and antidepressive and other medicinal products containing the same.Type: GrantFiled: July 18, 1994Date of Patent: April 23, 1996Assignee: Adir et CompagnieInventors: Gerald Guillaumet, Beatrice Guardiola
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Patent number: 5508277Abstract: Novel bicyclic pyrimidine compounds for use as drugs and having formula (I). Said novel compounds and physiologically tolerable salts thereof may be used in therapeutics, particularly for suppressing tumour cell resistance to antineoplastic agents.Type: GrantFiled: August 10, 1994Date of Patent: April 16, 1996Assignee: Adir Et CompagnieInventors: Gilbert Regnier, Alain Dhainaut, Ghanem Atassi, Alain Pierre
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Patent number: 5506237Abstract: The invention relates to the compounds of formula (I): ##STR1## in which: A represents, with the carbon and nitrogen atoms to which it is attached, a heterocycle,B represents, with the nitrogen atom to which it is attached, a heterocycle,n is equal to 1, 2, 3 or 4,R represents phenyl substituted by at least one halogen or alkyl, hydroxyl, alkoxy, trifluoromethyl, nitro, amino, cyano, carboxyl or alkoxycarbonyl, benzyl, thienyl or pyridyl. The compounds may be used as medicaments.Type: GrantFiled: March 23, 1994Date of Patent: April 9, 1996Assignee: Adir et CompagnieInventors: Guillaume De Nanteuil, Bernard Protevin, Georges Remond, Jean Lepagnol, Veronique Heidet
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Patent number: 5506245Abstract: The compounds are 5-(4-substituted benzyl)thiazolidine-2,4-diones, enantiomers, diastereoisomers and pharmaceutically tolerable salts thereof, useful for treating conditions of insulin-resistance and/or non insulin-dependent diabetes.A compound disclosed is: .(R,S)-5-{4-[2-benzofuran-2-yl)carbonylamino)ethyl]benzyl}thiazolidine-2,4 -dione.Type: GrantFiled: January 19, 1995Date of Patent: April 9, 1996Assignee: ADIR et CompagnieInventors: Gilbert Regnier, Yves Charton, Jacques Duhault, Joseph Espinal
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Patent number: 5502215Abstract: A method for the purification of lactide is provided which permits lactide of high optical purity or DL-lactide of high purity to be produced from crude lactide by the removal of meso-lactide from the crude lactide. This method for the purification of lactide is characterized by causing a mixture containing L-lactide and/or D-lactide together with meso-lactide to contact with water thereby effecting hydrolysis of meso-lactide. This method can remove meso-lactide from crude lactide and produce DL-lactide and/or optically active lactide of high optical purity in high yield and, in the production of optically active lactide, can eliminate the restrictions otherwise imposed on the formation of meso-lactide. Thus, it lends itself to the simplification of the procedure for the synthesis of lactide.Type: GrantFiled: December 2, 1994Date of Patent: March 26, 1996Assignee: Musashino Chemical Laboratory, Ltd.Inventors: Yoshiaki Yamaguchi, Tomohiro Arimura
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Patent number: 5500426Abstract: A compound selected from those of formula (I): ##STR1## in which A represents ##STR2## X represents N--R.sub.4 or oxygen, and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, n and m are as defined in the description,useful in improving glucose tolerance in the treatment of non-insulin-dependent diabetes.Type: GrantFiled: April 19, 1995Date of Patent: March 19, 1996Assignee: Adir et CompagnieInventors: Jean-Jacques Godfroid, Aazdine Lamouri, Estera Touboul, Xuan Wang, Pierre Renard, Bruno Pfeiffer, Beatrice Guardiola