Patents Represented by Attorney Gordon W. Hueschen
  • Patent number: 5998461
    Abstract: This invention relates to benzofuran/pyran derivatives of a new tricyclic amide compound, their composition and method of use for treating disorders of the melatoninergic system.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: December 7, 1999
    Assignee: Adir Et Compagnie
    Inventors: Daniel Lesieur, Patrick Depreux, Ve'ronique Leclerc, Hamid Ait Mansour, Philippe Delagrange, Pierre Renard
  • Patent number: 5925665
    Abstract: Compound of formula (I): in which R is as defined in the description, as well as their isomers and their pharmaceutically acceptable acid additions salts. Medicinal products containing the same are useful as Imidazoline receptors ligand.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: July 20, 1999
    Assignee: Adir Et Compagnie
    Inventors: Marc Payard, Saadia Danoun, Genevieve Baziard-Mouysset, Maria Anastassiadou, Daniel-Henri Caignard, Pierre Renard, Dominique Manechez, Elizabeth Scalbert, Marie-Claire Rettori
  • Patent number: 5849781
    Abstract: The invention relates to a compound selected from these of formula (I): ##STR1## in which R.sub.7, R.sub.8, Y, n and A are as defined in the description, and medicinal product containing the same useful for treating a disorder of the melatoninergic system.
    Type: Grant
    Filed: October 1, 1997
    Date of Patent: December 15, 1998
    Assignee: Adir Et Compagnie
    Inventors: Michel Langlois, Monique Mathe-Allainmat, Philippe Delagrange, Pierre Renard, Beatrice Guardiola
  • Patent number: 5731352
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which A, R.sub.1, R'.sub.1, R.sub.2, R.sub.3 and n are as defined in the description, and medicinal product containing the same useful for treating a mammal afflicted with a disorder of the melatoninergic system.
    Type: Grant
    Filed: May 30, 1996
    Date of Patent: March 24, 1998
    Assignee: Adir Et Compagnie
    Inventors: Daniel Lesieur, Veronique Leclerc, Patrick Depreux, Philippe Delagrange, Pierre Renard
  • Patent number: 5726177
    Abstract: Novel indole-derived azylpiperazines of general formula (I), wherein, inter alia, R.sub.1 is NH.sub.2 or NO.sub.2, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3 and R.sub.4 are H, Z is --C-- and X is 0. Methods for preparing such derivatives and the therapeutical uses thereof are also disclosed.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: March 10, 1998
    Assignee: Pierre Fabre Medicament
    Inventors: Serge Halazy, Michel Perez, Michael Briley, Peter Pauwels
  • Patent number: 5726208
    Abstract: New compounds of formula: ##STR1## wherein: --A--D--E, X, n, Y and Z are as defined in the description, in racemic form and in the form of optical isomers,and their addition salts with pharmaceutically acceptable acids.Those compounds may be used as medicaments.
    Type: Grant
    Filed: October 11, 1996
    Date of Patent: March 10, 1998
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Bertrand Goument, Jean-Christophe Harmange, Joel Vian, Aimee Dessinges, Mark Millan, Valerie Audinot
  • Patent number: 5564777
    Abstract: A foldable chair entirely in the form of a single piece of plastic, comprising a seat, a back hingedly connected to the seat, arm rests hingedly connected to the side edges of the seat, a rear leg assembly hingedly connected to the rear edge of the seat, and a front leg assembly hingedly connected to the front edge of the seat. The entire structure including the hinges is integral and comprised of the same piece of plastic material. The chair is erected by folding the front and rear leg assemblies in place, folding the arm rests over the seat, thereby retaining the leg assemblies in place, and affixing the arm rests to the back of the chair, thereby resulting in a strong rigid chair.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 15, 1996
    Inventor: Franklin J. Wild
  • Patent number: 5565580
    Abstract: The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof whereinone R.sup.21 and R.sup.22 is alkyl and the other is hydrogen or both of R.sup.21 and R.sup.22 are hydrogen;and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.11, R.sup.12, R.sup.13, and R.sup.14 each independently are hydrogen, halogen, CF.sub.3, CN, or NO.sub.2 ; provided that at least one of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.11, R.sup.12, R.sup.13, and R.sup.14 are different from hydrogenThe compounds are useful as in vivo active glutamate antagonists.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: October 15, 1996
    Assignee: NeuroSearch A/S
    Inventor: Frank W atjen
  • Patent number: 5536719
    Abstract: A compound of formula (I): ##STR1## in the form of its S enantiomer, its addition salts with a pharmaceutically acceptable acid or base and medicinal product containing the same are useful for the treatment or prevention of pathologies associated with dysfunction of glutamatergic neurotransmission.
    Type: Grant
    Filed: July 11, 1995
    Date of Patent: July 16, 1996
    Assignee: Adir et Compagnie
    Inventors: Alex Cordi, Michael Spedding, Bernard Serkiz, Jean Lepagnol, Patrice Desos, Philippe Morain
  • Patent number: 5534511
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, X and n are as defined in the description, the optical isomers thereof, and the addition salts thereof with a pharmaceutically acceptable acid or base and medicinal product containing the same, useful for treating a mammal afflicted with a pathology associated with the sigma receptors.
    Type: Grant
    Filed: March 21, 1995
    Date of Patent: July 9, 1996
    Assignee: Adir et Compagnie
    Inventors: Ange Mouithys-Mickalad, Patrick Depreux, Daniel Lesieur, Gerard Adam, Daniel-Henri Caignard, Pierre Renard, Marie-Claire Rettori
  • Patent number: 5525597
    Abstract: Insecticidal compositions, comprising normally-employed insecticides but comprising also an effective activity-enhancing amount of capsaicin or other capsaicinoid, especially in the form of capsicum, exhibit synergistic effects against numerous insects, including especially bud worms, boll worms, cabbage loopers, army worms, beet army worms, and beetles, and are especially effective on cotton, soybeans, common garden vegetables, and flowers, when sprayed on the insect or its habitat, especially as an aqueous solution, suspension, or emulsion. Larger crop stands may be effectively treated by aerial spraying from the usual crop-dusting airplane.
    Type: Grant
    Filed: December 14, 1993
    Date of Patent: June 11, 1996
    Assignee: Kalamazoo Holdings, Inc.
    Inventors: Gary C. Hainrihar, James G. Dubberly, John T. Greenlee
  • Patent number: 5512595
    Abstract: New substituted phenoxyisobutyric acids and esters that can be used as medicaments and correspond to the formula: ##STR1## wherein X, A, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and Z are as defined in the description.Those compounds and their physiologically tolerable salts can be used therapeutically.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: April 30, 1996
    Assignee: Adir et Compagnie
    Inventors: Gilbert Regnier, Claude Guillonneau, Jean-Paul Vilaine, Albert Lenaers, Christine Breugnot
  • Patent number: 5512569
    Abstract: The invention relates to the compounds of formula (I): ##STR1## in which R.sub.1 and R.sup.2 are as defined in the description, the optical isomers thereof,and an addition salt thereof with a pharmaceutically-acceptable acid or base, and medicinal product useful for treating a mammal afflicted with a disease associated with sigma receptors.
    Type: Grant
    Filed: March 21, 1995
    Date of Patent: April 30, 1996
    Assignee: Adir et Compagnie
    Inventors: Hamid A. Mansour, Thierry Taverne, Raymond Houssin, Isabelle Lesieur, Patrick Depreux, Geard Adam, Daniel-Henri Caignard, Pierre Renard, Marie-Claire Rettori
  • Patent number: 5510408
    Abstract: A composition of methacrilic resin which constitutes a resin possessing an outstandingly easy release from the mold of injection molding machine without defilement of the stamper and the peripheral ring of stamper holder, and therefore proves suitable material for replica of raser disk is provided. This methacrylic resin composition is characterized by having incorporated in a methyl methacrylate copolymer the three lubricant components, i.e. a higher alcohol (x), a monoglyceride of a higher fatty acid (y), and a paraffin (z), in such amounts that the individual contents of (x), (y), and (z) are in the respective ranges of 0.05 to 0.2% by weight, 0.05 to 0.2% by weight, and 0.02 to 0.15% by weight and the total content of (x), (y), and (z) is in the range of 0.2 to 0.35% by weight.
    Type: Grant
    Filed: May 26, 1994
    Date of Patent: April 23, 1996
    Assignee: Kuraray Co., Ltd.
    Inventors: Yoshio Fuchigami, Kouichi Warino, Shigeo Matsumaru, Yosokichi Kobayashi
  • Patent number: 5510374
    Abstract: The invention relates to compounds of the formula (I): ##STR1## in which: Z represents oxygen,R.sub.1 represents alkyl,R.sub.2 represents hydrogen or alkyl,n represents 1 through 6,R.sub.3 represents unsubstituted or substituted phenylacylamino, and antidepressive and other medicinal products containing the same.
    Type: Grant
    Filed: July 18, 1994
    Date of Patent: April 23, 1996
    Assignee: Adir et Compagnie
    Inventors: Gerald Guillaumet, Beatrice Guardiola
  • Patent number: 5508277
    Abstract: Novel bicyclic pyrimidine compounds for use as drugs and having formula (I). Said novel compounds and physiologically tolerable salts thereof may be used in therapeutics, particularly for suppressing tumour cell resistance to antineoplastic agents.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: April 16, 1996
    Assignee: Adir Et Compagnie
    Inventors: Gilbert Regnier, Alain Dhainaut, Ghanem Atassi, Alain Pierre
  • Patent number: 5506237
    Abstract: The invention relates to the compounds of formula (I): ##STR1## in which: A represents, with the carbon and nitrogen atoms to which it is attached, a heterocycle,B represents, with the nitrogen atom to which it is attached, a heterocycle,n is equal to 1, 2, 3 or 4,R represents phenyl substituted by at least one halogen or alkyl, hydroxyl, alkoxy, trifluoromethyl, nitro, amino, cyano, carboxyl or alkoxycarbonyl, benzyl, thienyl or pyridyl. The compounds may be used as medicaments.
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: April 9, 1996
    Assignee: Adir et Compagnie
    Inventors: Guillaume De Nanteuil, Bernard Protevin, Georges Remond, Jean Lepagnol, Veronique Heidet
  • Patent number: 5506245
    Abstract: The compounds are 5-(4-substituted benzyl)thiazolidine-2,4-diones, enantiomers, diastereoisomers and pharmaceutically tolerable salts thereof, useful for treating conditions of insulin-resistance and/or non insulin-dependent diabetes.A compound disclosed is: .(R,S)-5-{4-[2-benzofuran-2-yl)carbonylamino)ethyl]benzyl}thiazolidine-2,4 -dione.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: April 9, 1996
    Assignee: ADIR et Compagnie
    Inventors: Gilbert Regnier, Yves Charton, Jacques Duhault, Joseph Espinal
  • Patent number: 5502215
    Abstract: A method for the purification of lactide is provided which permits lactide of high optical purity or DL-lactide of high purity to be produced from crude lactide by the removal of meso-lactide from the crude lactide. This method for the purification of lactide is characterized by causing a mixture containing L-lactide and/or D-lactide together with meso-lactide to contact with water thereby effecting hydrolysis of meso-lactide. This method can remove meso-lactide from crude lactide and produce DL-lactide and/or optically active lactide of high optical purity in high yield and, in the production of optically active lactide, can eliminate the restrictions otherwise imposed on the formation of meso-lactide. Thus, it lends itself to the simplification of the procedure for the synthesis of lactide.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: March 26, 1996
    Assignee: Musashino Chemical Laboratory, Ltd.
    Inventors: Yoshiaki Yamaguchi, Tomohiro Arimura
  • Patent number: 5500426
    Abstract: A compound selected from those of formula (I): ##STR1## in which A represents ##STR2## X represents N--R.sub.4 or oxygen, and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, n and m are as defined in the description,useful in improving glucose tolerance in the treatment of non-insulin-dependent diabetes.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: March 19, 1996
    Assignee: Adir et Compagnie
    Inventors: Jean-Jacques Godfroid, Aazdine Lamouri, Estera Touboul, Xuan Wang, Pierre Renard, Bruno Pfeiffer, Beatrice Guardiola